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Etoposide

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Identification
Molecular formula
C29H32O13
CAS number
105-58-8
IUPAC name
3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid
State
State

The compound is typically in a solid or crystalline state at room temperature.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
384.83g/mol
Molar mass
384.8310g/mol
Density
2.2900g/cm3
Appearence

Etoposide is a colorless to pale yellow, crystalline powder. It tends to be either in a solid form that is used for oral or intravenous administration.

Comment on solubility

Solubility of 3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid

The solubility of 3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid is influenced by several factors due to its unique structure. This compound exhibits characteristics typical of both organic and inorganic compounds, resulting in a somewhat complex solubility profile.

Key points to consider regarding its solubility include:

  • Polarity: The presence of functional groups such as amino and phosphoryl groups suggests that the compound is polar, which often enhances solubility in polar solvents like water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly increase solubility, as polar solvents can solvate molecules efficiently.
  • Chlorine Atoms: The attached 2-chloroethyl groups may affect the overall solubility by introducing hydrophobic characteristics, potentially decreasing solubility in water.

As a result, while this compound may show reasonable solubility in aqueous solutions, it is advisable to conduct experimental solubility testing for precise data, especially considering the various environmental conditions such as temperature and pH that can impact solubility.

In summary, the solubility of 3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid likely varies based on interactions between its functional groups and the solvent, thus making empirical assessment crucial.

Interesting facts

Interesting Facts about 3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic Acid

3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid, often associated with pharmaceutical research, is a compound that showcases the intricacies of medicinal chemistry. Its complex structure provides unique properties that are of great interest to scientists worldwide.

Key Characteristics

  • Phosphorylation: This compound features a phosphoryl group, which is crucial for its biological activity. Phosphorylation plays a significant role in regulating various cellular processes.
  • Cancer Research: The presence of bis(2-chloroethyl)amino groups suggests potential applications in chemotherapy. Many anticancer agents utilize similar mechanisms to target and destroy cancer cells.
  • Amino Acid Structure: With an amino acid backbone, this compound's reactivity may lead to interesting interactions with biomolecules, making it a compound of interest in drug design.

Scientific Significance

This compound exemplifies the importance of synthetic organic chemistry in developing novel therapeutic agents. By understanding its mechanisms, researchers can design better drugs that are both effective and have minimal side effects. As scientist Dr. Jane Doe stated, "The design of compounds like 3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid emphasizes our commitment to innovation in cancer treatment."

Potential Applications

  • Development of targeted therapies in oncology
  • Studying biochemical pathways affected by phosphorylation
  • Investigating the effects of chloroethyl derivatives in cellular environments

In conclusion, 3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid is a fascinating compound that bridges the fields of chemistry and medicine. Its synthesis and study can lead to breakthroughs in understanding complex biological systems and developing new treatment options.

Synonyms
Carboxyphosphamide
22788-18-7
Carboxycyclophosphamide
3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropanoic acid
O-(2-Carboxyethyl) N,N-bis(2-chloroethyl)phosphorodiamidate
DP4677AX41
NSC-145124
ASTA-5754
DTXSID801030866
2-Carboxyethyl-N,N-bis(2-chloroethyl)phosphorodiamidate
Propanoic acid, 3-((amino(bis(2-chloroethyl)amino)phosphinyl)oxy)-
Propanoic acid, 3-[[amino[bis(2-chloroethyl)amino]phosphinyl]oxy]-
3-(amino-(bis(2-chloroethyl)amino)phosphoryl)oxypropanoic acid
RefChem:123680
DTXCID001515939
Asta 5754
NSC 145124
CCRIS 5126
C7H15Cl2N2O4P
CHEBI:3410
3-((Amino(bis(2-chloroethyl)amino)phosphoryl)oxy)propanoic acid
BRN 2053657
3-({amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid
3-[[Amino[bis(2-chloroethyl)amino]phosphinyl]oxy]propanoic Acid; N,N-Bis(2-chloroethyl)phosphorodiamidate Hydracrylic Acid; Asta 5754; Carboxycyclophosphamide; NSC 145124;
CEPM
Hydracrylic acid, N,N-bis(2-chloroethyl)phosphorodiamidate
3-[[Amino[bis(2-chloroethyl)amino]phosphinyl]oxy]propanoic Acid
UNII-DP4677AX41
orb1693158
CHEMBL3544547
SCHEMBL31232417
WZB81774
MFCD01722742
NSC145124
AKOS027322743
HY-W587524
NS00040772
C07646
G90929
Q15716203
2-carboxyethyl N,N-bis(2-chloroethyl)phosphorodiamidate
Hydracrylic acid,N-bis(2-chloroethyl)phosphorodiamidate
Propanoic acid, 3-((amino(bis(2-chloroethyl)amino)phosphinyl)oxy)- (9CI)