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Kanamycin A

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Identification
Molecular formula
C18H36N4O11
CAS number
59-01-8
IUPAC name
3-amino-N-[5-amino-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-2-[3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide
State
State

Kanamycin A is typically found as a solid at room temperature.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
484.49g/mol
Molar mass
484.4740g/mol
Density
1.7900g/cm3
Appearence

Kanamycin A appears as a white to off-white powder. It is hygroscopic and soluble in water, creating a clear, colorless or slightly colored solution. It is practically insoluble in organic solvents such as alcohol, ether, or chloroform.

Comment on solubility

Solubility of 3-amino-N-[5-amino-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-2-[3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide

The solubility of the compound with the formula C18H36N4O11, commonly known as 3-amino-N-[5-amino-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-2-[3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide, exhibits notable characteristics when it comes to solubility.

Factors Influencing Solubility:

  • Hydrophilicity: The presence of multiple hydroxyl (-OH) groups suggests a significant degree of polarity, enhancing the compound's ability to interact with water molecules.
  • Amine Groups: The amino groups present may form hydrogen bonds with water, further facilitating solubility.
  • Molecular Weight: With a relatively high molecular weight, the compound's solubility may be more complex, depending on the balance between hydrophilic and hydrophobic regions.

It is often observed that compounds like this one, which possess a rich array of functional groups, tend to be soluble in polar solvents, such as:

  • Water
  • Ethanol
  • Dimethyl sulfoxide (DMSO)

In conclusion, while specific solubility data may vary with temperature and concentration, the structural characteristics of this compound strongly indicate a good level of solubility in polar solvents. As with many complex organic compounds, empirical testing is advisable to determine exact solubility under various conditions.

Interesting facts

Interesting Facts about 3-amino-N-[5-amino-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-2-[3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide

This compound, often referred to by its abbreviated name, showcases the intricate beauty and complexity of organic chemistry. Here are some fascinating insights:

  • Functional Diversity: The molecule features multiple functional groups including amino, hydroxy, and ether functionalities, which contribute to its biological activity.
  • Structural Complexity: With a multi-ring structure that incorporates both cyclohexyl and tetrahydropyran units, it serves as a testament to the creativity involved in chemical synthesis.
  • Biological Relevance: Compounds like this are often explored for their potential pharmaceutical applications, especially in areas requiring modulation of glycosylation processes or enzyme interactions.
  • Potential Therapeutic Uses: Due to its structural components, researchers speculate this compound may play a role in targeting metabolic pathways or even exhibit antiviral properties.
  • Chiral Centers: The presence of several chiral centers in this molecule suggests that it may exist in multiple stereoisomer forms, which can result in differing biological activities.

As noted by many chemists, "The complexity of a compound can often determine its utility in advanced research applications." This underscores not only the scientific intricacy of 3-amino-N-[5-amino-4-[6-(aminomethyl)-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-2-[3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydropyran-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide, but its potential as a significant player in the realm of therapeutic chemistry.


Synonyms
Isepamicine
NCGC00164587-01
3-amino-n-(5-amino-4-[(6-amino-6-deoxyhexopyranosyl)oxy]-2-{[3-deoxy-4-c-methyl-3-(methylamino)pentopyranosyl]oxy}-3-hydroxycyclohexyl)-2-hydroxypropanamide
SCHEMBL152418
CHEMBL143422
DTXSID40860726
3-amino-N-[5-amino-4-[6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide
Q554818