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Thiotepa

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Identification
Molecular formula
C6H12N3OPS
CAS number
52-24-4
IUPAC name
3-(aziridin-1-ium-1-yl)-N-[8-[3-(aziridin-1-ium-1-yl)propanoylamino]octyl]propanamide;dichloride
State
State

At room temperature, thiotepa is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
52.50
Melting point (Kelvin)
325.65
Boiling point (Celsius)
108.00
Boiling point (Kelvin)
381.15
General information
Molecular weight
189.24g/mol
Molar mass
189.2360g/mol
Density
1.0000g/cm3
Appearence

Thiotepa typically appears as a white crystalline powder. It is highly soluble in water and can also dissolve in alcohol or chloroform.

Comment on solubility

Solubility of 3-(aziridin-1-ium-1-yl)-N-[8-[3-(aziridin-1-ium-1-yl)propanoylamino]octyl]propanamide; dichloride

The solubility of 3-(aziridin-1-ium-1-yl)-N-[8-[3-(aziridin-1-ium-1-yl)propanoylamino]octyl]propanamide; dichloride presents an interesting challenge due to its complex chemical structure. Factors influencing its solubility include:

  • Ionization: The presence of the dichloride salt can enhance solubility in polar solvents due to the dissociation of ions.
  • Hydrophobic interactions: The lengthy hydrocarbon chains may limit solubility in purely aqueous environments, promoting a stronger affinity for non-polar solvents.
  • Functional Groups: The aziridin-1-ium moieties could impact solubility by engaging in hydrogen bonding with solvents, increasing miscibility with certain polar solvents.

Overall, the solubility behavior of this compound can be summarized as:

  1. Likely soluble in polar solvents due to ionic character.
  2. Possibly less soluble in apolar solvents given its extensive hydrophobic sections.
  3. Overall solubility is mediated by temperature, concentration, and the presence of other solutes.

In conclusion, the solubility of this compound is a dynamic property that can change with its environment, making it an intriguing subject for further research and application.

Interesting facts

Exploring 3-(aziridin-1-ium-1-yl)-N-[8-[3-(aziridin-1-ium-1-yl)propanoylamino]octyl]propanamide; dichloride

The compound 3-(aziridin-1-ium-1-yl)-N-[8-[3-(aziridin-1-ium-1-yl)propanoylamino]octyl]propanamide; dichloride is a fascinating example of how complex chemistry can lead to potent biological activity. Here are several interesting aspects:

  • Structural Complexity: This compound features a unique aziridine ring, which is a three-membered cyclic amine. Such rings are known for their strain and reactivity, making them valuable in organic synthesis and medicinal chemistry.
  • Biological Relevance: Due to its structure, particularly the presence of multiple amine groups, it has potential applications in drug design, especially as an antimicrobial agent. Researchers often study compounds like this for their ability to interact with biological systems.
  • Polyfunctional Nature: The multiple functional groups present, including the amide and aziridine moieties, suggest that this compound may engage in a variety of chemical reactions, which can be harnessed for creating new therapeutic agents or as intermediates in synthesis.
  • Ionic Characteristics: The dichloride salt form of this compound hints at its ionic nature, which could improve its solubility and stability in biological and chemical environments, enhancing its usability in various applications.

As you delve into the research surrounding 3-(aziridin-1-ium-1-yl)-N-[8-[3-(aziridin-1-ium-1-yl)propanoylamino]octyl]propanamide; dichloride, keep in mind the implications of its unique construction and the potential it holds for future scientific advancements. In the words of famous chemists, "In every compound lies a new possibility waiting to be unlocked." Happy exploring!

Synonyms
N,N'-Octamethylenebis(1-aziridinepropionamide) dihydrochloride
1-AZIRIDINEPROPIONAMIDE, N,N'-OCTAMETHYLENEBIS-, DIHYDROCHLORIDE
17446-94-5