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Thiotepa

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Identification
Molecular formula
C6H12N3PS
CAS number
52-24-4
IUPAC name
3-(aziridin-1-yl)-N-[8-[3-(aziridin-1-yl)propanoylamino]octyl]propanamide
State
State

At room temperature, thiotepa is typically in a solid state. It is stable under normal environmental conditions, although it decomposes when exposed to strong acidic or basic conditions.

Melting point (Celsius)
42.00
Melting point (Kelvin)
315.15
Boiling point (Celsius)
207.00
Boiling point (Kelvin)
480.15
General information
Molecular weight
189.25g/mol
Molar mass
189.2450g/mol
Density
1.0432g/cm3
Appearence

Thiotepa appears as a white crystalline powder. It is known for its fine, needle-like crystals that are characteristic of many small organic molecules. The compound does not exhibit any particular luminescence or notable chromatic features in its solid form.

Comment on solubility

Solubility of 3-(aziridin-1-yl)-N-[8-[3-(aziridin-1-yl)propanoylamino]octyl]propanamide

The solubility of 3-(aziridin-1-yl)-N-[8-[3-(aziridin-1-yl)propanoylamino]octyl]propanamide, a complex amide compound, can be quite intriguing due to its unique molecular structure. Several factors influence its solubility:

  • Polar and Nonpolar Interactions: The presence of aziridine rings and amido groups contributes to its polarity, potentially increasing solubility in polar solvents.
  • Chain Length: The long octyl side chain may promote hydrophobic interactions, making the compound less soluble in water but more soluble in organic solvents such as ethanol or dichloromethane.
  • pH Sensitivity: Solubility might be affected by the pH of the environment, as the ionization state of the amide could change, influencing its solubility characteristics.

In general, one can expect

3-(aziridin-1-yl)-N-[8-[3-(aziridin-1-yl)propanoylamino]octyl]propanamide to exhibit variable solubility depending on the solvent used:

  • Highly soluble in polar solvents like water at certain pH levels.
  • Moderate to low solubility in nonpolar solvents, influenced by the hydrophobic octyl chain.

In conclusion, the solubility profile of this compound is a delicate balance of its molecular structure, solvent interactions, and environmental conditions. Understanding these aspects is essential for applications in various chemical and biological contexts.

Interesting facts

Exploring 3-(aziridin-1-yl)-N-[8-[3-(aziridin-1-yl)propanoylamino]octyl]propanamide

This fascinating compound, known for its complex structure, holds considerable potential in the fields of medicinal chemistry and material science. Here are some notable facts to consider:

  • Unique Structure: The presence of aziridine rings in this compound introduces interesting properties due to their three-membered ring structure. This can lead to greater reactivity and interesting interactions in biological systems.
  • Potential Applications: Compounds featuring aziridine moieties are often explored for their use in drug development. They can not only serve as intermediates in organic synthesis, but also possess the potential to act as inhibitors or modulators for biological targets.
  • Versatile Linkages: The compound contains various functional groups that can facilitate interaction with biological membranes. This is particularly useful in drug design where specific targeting of receptor sites is critical.
  • Research Interest: The dual presence of aziridine groups makes this compound a subject of ongoing research. Scientists are investigating how altering various parameters within this framework can improve biological efficacy.
  • Potential for Targeted Delivery: The unique side chains extending from the primary structure may provide pathways for targeted delivery systems in pharmaceuticals, where conjugation with therapies can improve localized effects.

As we delve deeper into the structure-activity relationships of compounds like 3-(aziridin-1-yl)-N-[8-[3-(aziridin-1-yl)propanoylamino]octyl]propanamide, it is crucial to understand that small changes in molecular architecture can lead to significantly varied biological outcomes. This compound exemplifies the creativity of chemists in exploring new avenues in drug development.


In conclusion, with its rich chemistry and potential for applications, this compound stands at the intersection of innovation and scientific inquiry, reminiscent of the words of renowned chemist Linus Pauling: "The best way to have a good idea is to have a lot of ideas."

Synonyms
15379-40-5
3-(aziridin-1-yl)-N-[8-[3-(aziridin-1-yl)propanoylamino]octyl]propanamide
NSC111718
DTXSID70274857
NSC-111718
1-Aziridinepropionamide,N'-octamethylenebis-
1-Aziridinepropanamide,N'-1,8-octanediylbis-