Skip to main content

Amitriptyline

ADVERTISEMENT
Identification
Molecular formula
C20H23NO
CAS number
50-48-6
IUPAC name
3-benzhydryloxy-9-methyl-9-azabicyclo[3.3.1]nonane
State
State

At room temperature, Amitriptyline is typically found in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
388.40
Boiling point (Kelvin)
661.55
General information
Molecular weight
277.40g/mol
Molar mass
277.4030g/mol
Density
1.0700g/cm3
Appearence

Amitriptyline typically appears as white or practically white crystalline powder. It is odorless and has a slightly bitter taste. It is known for its hygroscopic properties, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of 3-benzhydryloxy-9-methyl-9-azabicyclo[3.3.1]nonane

3-benzhydryloxy-9-methyl-9-azabicyclo[3.3.1]nonane's solubility can be rather intriguing due to its unique chemical structure. Understanding the solubility of such a compound involves several factors:

  • Polarity: The presence of the benzhydryloxy group suggests a certain level of polarity, which can enhance solubility in polar solvents.
  • Hydrophobic Regions: The bicyclic structure contributes to hydrophobic character, potentially limiting solubility in water.
  • Solvent Compatibility: It may exhibit better solubility in organic solvents such as methanol, ethanol, or dimethyl sulfoxide (DMSO).

The interplay of these factors means that while it may dissolve well in organic media, its solubility in water could be considerably lower. Thus, this compound presents a classic example of the convergence of structure and solvation characteristics, making it a compelling subject of study in chemical solubilities.

In practical applications, knowing the solubility properties of 3-benzhydryloxy-9-methyl-9-azabicyclo[3.3.1]nonane is crucial for its use in formulations, where effective solubility can influence the bioavailability and efficacy of compound-based therapies.

Interesting facts

Interesting Facts About 3-benzhydryloxy-9-methyl-9-azabicyclo[3.3.1]nonane

3-benzhydryloxy-9-methyl-9-azabicyclo[3.3.1]nonane, a fascinating compound belonging to the family of bicyclic amines, exhibits a remarkable structure that contributes to its activity and potential applications. Below are some engaging insights into this compound:

  • Complex Structure: The bicyclic structure of this compound is characterized by the integration of nitrogen in its framework, which is significant for its biological activity.
  • Pharmacological Potential: Compounds with a similar bicyclic structure have been investigated for their potential as antidepressants and analgesics. The unique arrangement of atoms can influence how these compounds interact with neurotransmitter systems in the brain.
  • Synthesis Relevance: The synthetic pathways for creating this compound can involve multi-step reactions. Understanding these pathways is critical for researchers aiming to optimize the efficiency and yield of production.
  • Therapeutic Applications: With research ongoing, 3-benzhydryloxy-9-methyl-9-azabicyclo[3.3.1]nonane might contribute to the development of new medications targeting neurological conditions.
  • Structure-Activity Relationship (SAR): Studies focusing on SAR help scientists comprehend how variations in the chemical structure can alter pharmacological effects, paving the way for innovative drug design.

As we delve deeper into understanding compounds like this one, we uncover not only their chemical properties but also their potential roles in transforming therapeutic approaches. The challenges and triumphs in synthesizing and studying such compounds ignite curiosity and drive advancement in the field of medicinal chemistry.

Synonyms
N-Methyl-norgranatanol-3-alpha-benzhydrylaether [German]
1927-08-8
KSD 2032
KSD 2083
7079-18-7
BRN 1435658
3-alpha-(Diphenylmethoxy)-9-methyl-9-azabicyclo(3.3.1)nonane
9-AZABICYCLO(3.3.1)NONANE, 3-alpha-(DIPHENYLMETHOXY)-9-METHYL-
N-Methyl-norgranatanol-3-alpha-benzhydrylaether
N-Methyl-norgranatanol-3-beta-benzhydrylaether [German]
DTXSID00940932
3-beta-(Diphenylmethoxy)-9-methyl-9-azabicyclo(3.3.1)nonane
9-AZABICYCLO(3.3.1)NONANE, 3-beta-(DIPHENYLMETHOXY)-9-METHYL-
N-Methyl-norgranatanol-3-beta-benzhydrylaether
3-(diphenylmethoxy)-9-methyl-9-azabicyclo[3.3.1]nonane