Hydrochlorothiazide | Solubility of Things

Identification

Molecular formula

C₇H₈ClF₃N₃O₄S₂

CAS number

58-93-5

IUPAC name

3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

State

At room temperature, Hydrochlorothiazide is in a solid state. It is typically stored under standard conditions, away from excessive heat or moisture, to maintain its stability.

Melting point (Celsius)

273.00

Melting point (Kelvin)

546.00

Boiling point (Celsius)

0.00

Boiling point (Kelvin)

0.00

General information

Molecular weight

297.74g/mol

Molar mass

297.7390g/mol

Density

1.7173g/cm³

Appearence

Hydrochlorothiazide is a white, or almost white, crystalline powder. The compound is known for its ability to form fine crystals, providing a powdery appearance that is typical for many pharmaceutical compounds.

Comment on solubility

Solubility of 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

The solubility of 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide, with a chemical formula of C₇H₈ClF₃N₃O₄S₂, can exhibit a range of behaviors based on its structure. Understanding its solubility is crucial for applications in medicinal chemistry and environmental studies. Here are some factors influencing its solubility:

Polarity: The presence of sulfonamide and trifluoromethyl groups can influence how well the compound dissolves in different solvents.
Hydrogen Bonding: The ability of the compound to participate in hydrogen bonding may enhance its solubility in polar solvents.
Temperature: Solubility can change with temperature. Often, increasing temperature increases solubility for solid compounds.
Solvent Type: The compound may have varying solubility in polar solvents (like water) versus non-polar solvents (like hexane).

Furthermore, it is critical to consider that while some derivatives of this compound might be soluble, others may not display the same behavior due to the complexities of their molecular interactions. It is observed that compounds with similar structures often relate in solubility trends; thus, experimentally obtaining solubility data can provide valuable insights for researchers.

In conclusion, the solubility of 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide can be multi-faceted and highly dependent on its molecular characteristics and the conditions under which solubility is assessed.

Interesting facts

Interesting Facts about 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

This intriguing compound, known for its complex structure, is a member of the benzothiadiazine class, which has garnered interest in medicinal chemistry. Here are some compelling insights about this unique chemical:

Pharmaceutical Potential: Compounds within the benzothiadiazine family are often studied for their pharmacological properties, particularly in the context of antihypertensive and diuretic medications.
Trifluoromethyl Group: The presence of the trifluoromethyl group (–CF₃) enhances the compound's stability and lipophilicity, which helps in modulating its biological activity and bioavailability.
Thiadiazine Framework: The thiadiazine ring offers unique electronic properties that can influence reactivity and interactions with biological targets, making such compounds attractive for drug discovery.
Environmental Impact: This compound also reflects ongoing discussions regarding environmental sustainability, emphasizing the need for understanding the behavior of fluorinated compounds in ecosystems.
Diversity of Derivatives: The ability to modify the subtype groups on the benzothiadiazine core leads to a vast array of derivatives with varying properties, highlighting the versatility of synthetic chemistry in exploring diverse chemical spaces.

In conclusion, 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide represents a fascinating intersection of organic chemistry and medicinal applications. Its unique properties and potential applications make it a subject of ongoing research and exploration in the chemical sciences.

Synonyms

BENDROFLUMETHIAZIDE

Bendrofluazide

73-48-3

Naturetin

Aprinox

Benzhydroflumethiazide

Benzylrodiuran

Pluryl

Bentride

Berkozide

Bristuric

Bristuron

Flumesil

Niagaril

Plusuril

Poliuron

Sinesalin

Sodiuretic

Thiazidico

Benuron

Centyl

Intolex

Nikion

Orsile

Pluryle

Repicin

Salural

Salures

Urlea

Benzylhydroflumethiazide

Neo-naclex

Neo-rontyl

Relan beta

BHFT

Livesan

Benzydroflumethiazide

Bendroflumetiazida

Bendroflumethiazidum

Naturine

Rauzide

Naturetin-2.5

bendrofumethiazide

Bendroflumethazide

Rautrax N

Nateretin

Bendroflumetiazide

NATURETIN-5

NATURETIN-10

Be 724-A

Bendroflumethiazidum [INN-Latin]

Bendroflumetiazida [INN-Spanish]

BL H368

FT 81

HSDB 3293

NeoNaClex

UNII-5Q52X6ICJI

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide

EINECS 200-800-1

5Q52X6ICJI

NSC-758229

BRN 0373316

CHEBI:3013

DTXSID5022647

rac Bendroflumethiazide

3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide

MLS000028558

DTXCID402647

4-27-00-08041 (Beilstein Handbook Reference)

6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

NSC 758229

Bendroflumethiazide [USP:INN:BAN:JAN]

Flumersil

Naigaril

SMR000058802

Benzy-rodiuran

CORZIDE COMPONENT BENDROFLUMETHIAZIDE

3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Bendroflumetiazide [DCIT]

Bendroflumethiazidum (INN-Latin)

Bendroflumetiazida (INN-Spanish)

BENDROFLUMETHIAZIDE (MART.)

BENDROFLUMETHIAZIDE [MART.]

BENDROFLUMETHIAZIDE (USP-RS)

BENDROFLUMETHIAZIDE [USP-RS]

3-Benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide

BENDROFLUMETHIAZIDE (EP IMPURITY)

Bendroflumethiazide (USP:INN:BAN:JAN)

BENDROFLUMETHIAZIDE [EP IMPURITY]

Naturetin (TN)

(+/-)-3-BENZYL-3,4-DIHYDRO-6-(TRIFLUOROMETHYL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE

BENDROFLUMETHIAZIDE (EP MONOGRAPH)

BENDROFLUMETHIAZIDE [EP MONOGRAPH]

BENDROFLUMETHIAZIDE (USP MONOGRAPH)

BENDROFLUMETHIAZIDE [USP MONOGRAPH]

SR-01000000103

Bendroflumethiazide [INN]

Bendroflumethiazid

CAS-73-48-3

Relan .beta.

NCGC00016312-01

Bendroflumethiazide (JAN/USP/INN)

Prestwick_992

MFCD00078963

RELAN

Spectrum_001386

Opera_ID_1043

Prestwick0_000784

Prestwick1_000784

Prestwick2_000784

Prestwick3_000784

Spectrum2_001524

Spectrum3_001558

Spectrum4_000774

Spectrum5_001016

CHEMBL1684

SCHEMBL26016

BSPBio_000888

BSPBio_003036

KBioGR_001188

KBioSS_001866

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-,1,1-dioxide

MLS001076062

MLS002548857

Bendroflumethiazide (Standard)

DivK1c_000274

SPECTRUM1503104

SPBio_001308

SPBio_002827

(.+/-.)-Bendroflumethiazide

BPBio1_000978

GTPL7122

BENDROFLUMETHIAZIDE [MI]

BENDROFLUMETHIAZIDE [JAN]

HMS500N16

HY-B1363R

KBio1_000274

KBio2_001866

KBio2_004434

KBio2_007002

KBio3_002536

BENDROFLUMETHIAZIDE [HSDB]

C03AA01

NINDS_000274

BENDROFLUMETHIAZIDE [VANDF]

HMS1570M10

HMS1922E15

HMS2092J16

HMS2097M10

HMS2230G10

HMS3259D17

HMS3370I20

HMS3714M10

Pharmakon1600-01503104

BCP24525

HY-B1363

BENDROFLUMETHIAZIDE [WHO-DD]

Tox21_110365

CCG-39302

NSC758229

AKOS024255718

Tox21_110365_1

Bendroflumethiazide, analytical standard

DB00436

FR27485

HS-0095

NC00664

3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

IDI1_000274

BENDROFLUMETHIAZIDE [ORANGE BOOK]

NCGC00018194-02

NCGC00018194-03

NCGC00018194-04

NCGC00018194-08

NCGC00089729-02

NCGC00089729-03

(+-)-3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide, (+-)-

3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

DA-71371

SBI-0051772.P002

AB00052315

CS-0013104

EU-0009291

NS00007673

SW028069-4

UNM000000601501

BENDROFLUMETHIAZIDE COMPONENT OF CORZIDE

C07758

D00650

AB00052315_15

AB00052315_16

Q1169164

SR-01000000103-2

SR-01000000103-4

BRD-A80017228-001-05-9

BRD-A80017228-001-15-8

BRD-A80017228-001-24-0

BRD-A80017228-001-25-7

Z1575277625

Bendroflumethiazide, British Pharmacopoeia (BP) Reference Standard

Bendroflumethiazide, European Pharmacopoeia (EP) Reference Standard

Bendroflumethiazide, United States Pharmacopeia (USP) Reference Standard

3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

+/--3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

200-800-1

2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 3,4-DIHYDRO-3-(PHENYLMETHYL)-6-(TRIFLUOROMETHYL)-, 1,1-DIOXIDE, (+/-)-

3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;Aprinox

3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide #