Skip to main content

Chlorambucil

ADVERTISEMENT
Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid
State
State

At room temperature, chlorambucil is a solid. It is reasonably stable but should be stored under recommended conditions to prevent degradation.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
304.68g/mol
Molar mass
304.6800g/mol
Density
1.1990g/cm3
Appearence

Chlorambucil typically appears as a pale, off-white to light yellow crystalline powder. It can have a faint odor, which is characteristic of many chlorinated organic compounds.

Comment on solubility

Solubility of 3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid

The solubility of 3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid can be influenced by several factors due to its complex structure. Here are some key points to consider:

  • Polarity: The presence of polar functional groups may contribute to solubility in polar solvents like water, while the aromatic structure may enhance solubility in non-polar solvents.
  • pH Dependency: As a benzoic acid derivative, solubility may vary with changes in pH, potentially increasing in alkaline conditions where deprotonation occurs.
  • Solvent Interaction: This compound may show preferential solubility in organic solvents such as dimethyl sulfoxide (DMSO) or acetone, given the hydrocarbon segments present.
  • Hydrogen Bonding: The carboxylic group can form hydrogen bonds, impacting its solubility in polar media.
  • Temperature Effects: Like many compounds, an increase in temperature could lead to enhanced solubility due to increased kinetic energy disrupting intermolecular attractions.

In summary, while it is challenging to provide a definitive solubility profile without experimental data, the influence of polarity and functional groups plays a crucial role in determining the solubility characteristics of 3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid. Further studies and empirical testing are recommended for precise solubility conclusions.

Interesting facts

Exploring 3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid

3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid is an intriguing compound that captures the attention of chemists due to its multifaceted applications and properties. Here are some interesting aspects to consider:

  • Medicinal Relevance: This compound is part of a class of compounds known as alkylating agents, commonly used in chemotherapy. Its ability to modify DNA can help hinder the proliferation of cancer cells, making it a valuable subject of study in oncology.
  • Synthesis Challenges: The synthesis of this compound involves careful manipulation of chemical reactions. The introduction of chlorine atoms and the amine group must be precisely controlled to obtain the desired product without unwanted side reactions.
  • Structure-Activity Relationship (SAR): Researchers often investigate how the structural components of compounds like this one influence their biological activity. This relationship can provide insights into how modifications can enhance efficacy or reduce toxicity.
  • Environmental Considerations: With the focus on pharmaceuticals, understanding the environmental impact of such compounds is crucial. The persistence of certain chemical forms in nature and their potential to bioaccumulate can raise concerns about their long-term ecological effects.
  • Outreach in Education: The study of 3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid serves as an excellent topic for chemistry students. It provides a practical example of how chemical knowledge is applied in real-world scenarios, emphasizing the importance of organic chemistry in medicine.

In summary, 3-[bis(2-chloroethyl)amino]-2,4-dimethyl-benzoic acid is a compound rich in scientific significance. Its role in cancer treatment, challenges in synthesis, and implications for both human health and the environment make it a noteworthy topic for further exploration. As the famous chemist Marie Curie once said, “Nothing in life is to be feared, it is only to be understood.” Engaging with compounds like this encourages a deeper understanding of chemistry's impact on our world.

Synonyms
24830-45-3
BRN 2746445
BENZOIC ACID, 3-(BIS(2-CHLOROETHYL)AMINO)-2,4-DIMETHYL-
3-(Bis(2-chloroethyl)amino)-2,4-dimethylbenzoic acid
3-[bis(2-chloroethyl)amino]-2,4-dimethylbenzoic acid
DTXSID20179540
RefChem:327156
DTXCID80102031