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Chlorambucil

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Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
3-[bis(2-chloroethyl)amino]benzoyl chloride
State
State

At room temperature, Chlorambucil is a solid. It is usually handled in this solid form before being processed or dissolved for various applications, typically in pharmaceutical settings.

Melting point (Celsius)
65.50
Melting point (Kelvin)
338.65
Boiling point (Celsius)
112.50
Boiling point (Kelvin)
385.65
General information
Molecular weight
304.13g/mol
Molar mass
304.1320g/mol
Density
1.3728g/cm3
Appearence

Chlorambucil typically appears as a pale yellow crystalline solid. Its appearance can be described as a fine powder or small crystalline pieces that maintain a uniformly pale coloring.

Comment on solubility

Solubility of 3-[bis(2-chloroethyl)amino]benzoyl chloride

3-[bis(2-chloroethyl)amino]benzoyl chloride is a chemical compound that exhibits interesting solubility characteristics. Its solubility can be influenced by several factors, including:

  • Polarity: The presence of the chloroethyl groups introduces a degree of polarity, which impacts its interactions with various solvents.
  • Solvent Types: This compound is expected to have a preference for polar organic solvents due to its structure. Common solvents may include:
    • Dichloromethane
    • Acetone
    • Ethyl acetate
  • Temperature Effects: Increasing the temperature can potentially enhance solubility, as the kinetic energy allows for better interaction between solute and solvent molecules.

It is also important to note that 3-[bis(2-chloroethyl)amino]benzoyl chloride is unlikely to be soluble in water owing to its predominantly hydrophobic character. As a general rule, the solubility of organic compounds can often be summarized by the principle of "like dissolves like," suggesting that non-polar substances tend to dissolve well in non-polar solvents, while polar compounds favor polar solvents.

In conclusion, understanding the solubility of this compound can provide insights into its behavior in various chemical environments, making it crucial for applications that involve dissolution, reactions in solution, or formulations.

Interesting facts

Interesting Facts about 3-[bis(2-chloroethyl)amino]benzoyl chloride

The compound 3-[bis(2-chloroethyl)amino]benzoyl chloride, also known as benzoyl chloride derivative, is an intriguing molecule with significant applications in the field of organic chemistry and medicinal sciences.

Key Characteristics

  • Pharmaceutical Relevance: This compound serves as a vital intermediate in the synthesis of various pharmaceuticals, especially in the manufacture of anticancer agents.
  • Mechanism of Action: The presence of the bis(2-chloroethyl) amino group is particularly noteworthy; it often plays a crucial role in its ability to alkylate DNA, which can lead to apoptosis of cancerous cells.
  • Synthetic Utility: Beyond pharmaceuticals, it can also be utilized in the production of dyes and agrochemicals, showcasing its versatility in synthetic organic chemistry.

Important Considerations

While working with this compound, safety precautions are imperative due to its reactive nature:

  • It is recommended to handle it in a well-ventilated laboratory.
  • Personal protective equipment (PPE) such as gloves and goggles should always be worn.
  • Due to its potential carcinogenic properties, it should be treated with caution.

Fun Fact

One fascinating aspect of the chlorinated compounds like 3-[bis(2-chloroethyl)amino]benzoyl chloride is their historical significance in chemical warfare. Some similar chemicals were initially explored during conflicts before being redirected towards therapeutic applications.

In conclusion, the study of 3-[bis(2-chloroethyl)amino]benzoyl chloride not only illustrates the intricate balance between chemistry and its real-world applications but also emphasizes the importance of safety in the laboratory environment. As a compound with both beneficial and hazardous properties, it makes for an essential subject of study for any budding chemist!

Synonyms
24813-11-4
BENZOYL CHLORIDE, m-(BIS(2-CHLOROETHYL)AMINO)-
m-(Bis(2-chloroethyl)amino)benzoyl chloride
ZW5YW7YTH9
Benzoyl chloride, 3-(bis(2-chloroethyl)amino)-
NSC-240369
3-(Bis(2-chloroethyl)amino)benzoyl chloride
Benzoyl chloride, 3-[bis(2-chloroethyl)amino]-
Benzoyl chloride, m-[bis(2-chloroethyl)amino]-
NSC 240369
BRN 2810542
NSC240369
UNII-ZW5YW7YTH9
SCHEMBL7474438
DTXSID70179510