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Carmustine

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Identification
Molecular formula
C5H13Cl2N3O2
CAS number
154-93-8
IUPAC name
3-[bis(2-chloroethyl)aminomethyl]imidazolidine-2,4-dione
State
State

Carmustine is typically a solid at room temperature. It is used mainly in its dry form and is reconstituted in solution for medical applications. It should be handled carefully as it is an alkylating agent, commonly used in chemotherapy.

Melting point (Celsius)
30.00
Melting point (Kelvin)
303.15
Boiling point (Celsius)
312.00
Boiling point (Kelvin)
585.15
General information
Molecular weight
214.08g/mol
Molar mass
214.0630g/mol
Density
1.6400g/cm3
Appearence

Carmustine appears as pale orange-yellow crystals or crystalline powder. It is quite sensitive to light and moisture, which can lead to degradation, and thus is often stored in airtight containers protected from light.

Comment on solubility

Solubility of 3-[bis(2-chloroethyl)aminomethyl]imidazolidine-2,4-dione

The solubility of 3-[bis(2-chloroethyl)aminomethyl]imidazolidine-2,4-dione can be characterized by several key factors that influence its behavior in various solvents. Generally, this compound features a complex structure that may affect its interaction with solvents.

Factors Influencing Solubility

  • Polarity: The presence of the imidazolidine ring and functional groups contributes to the overall polarity of the molecule, which can enhance solubility in polar solvents.
  • Hydrogen Bonding: The potential for hydrogen bonding due to the amide functional groups may lead to increased solubility in water and other hydrogen-bonding solvents.
  • Temperature: Solubility often increases with temperature, potentially allowing for better dissolution in solution when heated.
  • pH Levels: The solubility may vary significantly with changes in pH, particularly due to protonation or deprotonation of the amine groups.

It is essential to note that specific solubility data may vary based on experimental conditions. As a result, while the compound may show certain trends in solubility, practitioners should conduct thorough solubility tests under their specific conditions to obtain accurate measurements.

In summary, the solubility of 3-[bis(2-chloroethyl)aminomethyl]imidazolidine-2,4-dione is influenced by a variety of factors, and understanding these can provide insight into its behavior in different chemical environments.

Interesting facts

Interesting Facts about 3-[bis(2-chloroethyl)aminomethyl]imidazolidine-2,4-dione

This compound, with its intricate structure and functionality, has garnered interest in various scientific domains, particularly in medicinal chemistry. Here are some intriguing aspects:

  • Biological Activity: This compound is known for its role in medicinal applications, particularly as a potential anticancer agent. Its structure allows it to interact with biological targets effectively, leading to research exploring its therapeutic effects.
  • Mechanism of Action: The imidazolidine core, combined with the bis(2-chloroethyl)amino substituents, suggests mechanisms involving DNA alkylation, which is a common action among many cytotoxic compounds.
  • Synthesis: The compound can be synthesized through various chemical pathways, including the use of specific reagents and controlled reactions that highlight the elegance of organic synthesis techniques.
  • Pharmaceutical Research: Its unique properties make it significant in the field of drug design, prompting studies that explore modifications to enhance its efficacy and selectivity towards cancer cells.
  • Toxicology Considerations: Given its structure, it’s crucial to investigate toxicity and safety profiles, emphasizing the need for thorough testing during preclinical trials.

In the words of a researcher in the field: "Understanding the intricacies of compounds like this provides invaluable insight into the development of next-generation therapeutics." As scientists continue to explore its capabilities, the hope is to uncover more about its potential in fighting diseases and improving health outcomes.


Synonyms
BRN 0654389
7750-75-6
3-(Bis(2-chloroethyl)aminomethyl)hydantoin
HYDANTOIN, 3-(BIS(2-CHLOROETHYL)AMINOMETHYL)-
3-(Bis-(2-chloraethyl)aminomethyl)hydantoin [German]
3-(Bis-(2-chloraethyl)aminomethyl)hydantoin
DTXSID40228206
5-24-05-00189 (Beilstein Handbook Reference)
DTXCID20150697