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Amiloride HES

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Identification
Molecular formula
C6H15NO5S
CAS number
2016-88-8
IUPAC name
3-bromo-4-[3-(2-bromo-4-carbamimidoyl-phenoxy)propoxy]benzamidine;2-hydroxyethanesulfonic acid
State
State
At room temperature, Amiloride HES is in a solid state, existing as a crystalline powder.
Melting point (Celsius)
299.00
Melting point (Kelvin)
572.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
534.49g/mol
Molar mass
252.2690g/mol
Density
1.9000g/cm3
Appearence

Amiloride HES appears as a white to off-white crystalline substance. It is typically presented in its salt form, which aids in its solubility for pharmacological use. The compound possesses a powdery texture.

Comment on solubility

Solubility of 3-bromo-4-[3-(2-bromo-4-carbamimidoyl-phenoxy)propoxy]benzamidine; 2-hydroxyethanesulfonic acid

The solubility of 3-bromo-4-[3-(2-bromo-4-carbamimidoyl-phenoxy)propoxy]benzamidine in conjunction with 2-hydroxyethanesulfonic acid can be quite complex due to their structural characteristics. Here are some key points to consider:

  • Polar vs. Non-Polar: The presence of polar functional groups can enhance solubility in polar solvents, such as water. Conversely, if hydrophobic regions dominate, solubility may decrease.
  • pH Sensitivity: The acid-base properties influenced by the sulfonic acid moiety may affect solubility, leading to potential changes in solubility at different pH levels.
  • Intermolecular Interactions: The interactions between the molecules, such as hydrogen bonding and dipole-dipole interactions, may impact how well the compounds dissolve in a given solvent.
  • Temperature Dependency: Solubility often varies with temperature; increased temperature typically enhances solubility for many compounds.

In conclusion, the solubility of this compound is a function of its intricate molecular structure and environmental conditions. As a general tendency, compounds with significant hydrogen-bonding capabilities tend to have favorable solubility profiles in aqueous environments, but each case can differ markedly.

Interesting facts

Interesting Facts about 3-Bromo-4-[3-(2-bromo-4-carbamimidoyl-phenoxy)propoxy]benzamidine with 2-Hydroxyethanesulfonic Acid

This complex compound is notable for its structural sophistication and functionality, combining elements that are significant in various fields of chemistry. Here are some fascinating aspects:

  • Multi-functional Design: The compound features a unique arrangement that enhances its reactivity and potential utility in organic synthesis. The presence of both bromine atoms and a benzamidine moiety indicates its capability as a reactive intermediate.
  • Pharmacological Potential: Benzamidine derivatives are often explored for their biological activity. Compounds like this one can serve as potential agents in medicinal chemistry, impacting a variety of biological processes.
  • Hydroxyethanesulfonic Acid Component: This acidic component adds solubility and stability to the overall compound structure, which is crucial for biological applications. It can also influence the compound's electrochemical properties.
  • Research Interest: Scientists are continually studying similar compounds for their roles in enzyme inhibition and drug development; as such, this compound may contribute to broader therapeutic strategies.
  • Complex Synthesis: The synthesis of such compounds requires advanced techniques in organic chemistry, showcasing the intricacies and methodologies involved in constructing multi-functional organic molecules.

In summary, this compound exemplifies the intersection of chemical ingenuity and potential therapeutic application. Scientists are drawn to its complexity and the opportunities it presents for research in pharmacology and organic synthesis.

Synonyms
Brulidine
3-bromo-4-[3-(2-bromo-4-carbamimidoylphenoxy)propoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
SCHEMBL871570
CHEMBL3277938
NSC33424
NSC528031
AKOS032947667