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Iodixanol

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Identification
Molecular formula
C18H24I3N3O9
CAS number
92339-11-2
IUPAC name
3-(butanoylamino)-2,4,6-triiodo-benzoic acid
State
State

At room temperature, Iodixanol is a solid and presents as a white crystalline powder. It is stable under normal conditions and is primarily used in medical settings as a contrast medium.

Melting point (Celsius)
164.00
Melting point (Kelvin)
437.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
791.12g/mol
Molar mass
791.1230g/mol
Density
2.0900g/cm3
Appearence

Iodixanol appears as a white crystalline powder. It is non-ionic and a water-soluble contrast agent. It is specifically designed for imaging procedures and is highly visible under X-ray due to its iodine content.

Comment on solubility

Solubility of 3-(butanoylamino)-2,4,6-triiodo-benzoic acid

The solubility of 3-(butanoylamino)-2,4,6-triiodo-benzoic acid can be described as quite complex due to its molecular structure and the presence of multiple functional groups. Several factors influence the solubility of this compound:

  • Polarity: The presence of both the amino group and the carboxylic acid group increases polarity, which may enhance solubility in polar solvents such as water.
  • Hydrophobic Regions: The butanoylamino part of the molecule introduces a hydrophobic region, which could limit solubility in polar solvents while enhancing solubility in organic solvents.
  • Iodine Atoms: The tri-iodination of the benzene ring significantly affects molecular interactions, often leading to lower solubility in aqueous environments due to increased hydrophobic character.
  • pH Dependence: The carboxylic acid group can ionize in alkaline conditions, potentially increasing solubility in basic solutions.

In summary, 3-(butanoylamino)-2,4,6-triiodo-benzoic acid exhibits variable solubility characteristics driven by a balance of hydrophilic and hydrophobic interactions. In practical applications, it is essential to consider both the solvent used and the pH of the solution to optimize solubility. For effective use in chemical processes, testing solubility in different solvents remains crucial.

Interesting facts

3-(Butanoylamino)-2,4,6-triiodo-benzoic acid

3-(Butanoylamino)-2,4,6-triiodo-benzoic acid is a fascinating compound that plays a significant role in various fields, particularly in pharmaceuticals and biochemistry. Here are some interesting facts about this intriguing compound:

  • Medical Applications: This compound is frequently utilized in the development of radiographic contrast agents, which enhance the visibility of tissues and organs in imaging techniques such as X-rays.
  • Mechanism of Action: The presence of iodine in its structure contributes to the compound's high atomic number, which is essential for absorbing X-rays, thereby making it valuable in medical diagnostics.
  • Research Significance: Studies have shown that derivatives of this compound may have potential applications in drug delivery systems, targeting specific tissues for more effective treatment.
  • Synthesis Challenges: The synthesis of 3-(butanoylamino)-2,4,6-triiodo-benzoic acid involves several steps and requires precise control of reaction conditions to ensure high yield and purity.
  • Structure-Activity Relationship: Understanding how structural variations affect the biological activity of this compound can lead to the development of new therapeutic agents with enhanced efficacy.
  • Environmental Considerations: As with many iodine-containing compounds, careful consideration must be given to their environmental impact, especially regarding disposal and potential bioaccumulation.

In the words of chemist Robert H. Grubbs, “Innovation happens at the intersections.” With compounds like 3-(butanoylamino)-2,4,6-triiodo-benzoic acid constantly being explored, there is immense potential for innovation in medical diagnostics and treatment solutions.

Synonyms
BRN 3395195
3-Butyrylamino-2,4,6-triiodobenzoic acid
BENZOIC ACID, 3-BUTYRAMIDO-2,4,6-TRIIODO-
3-Butyramido-2,4,6-triiodobenzoic acid
7181-71-7
Benzoic acid, 2,4,6-triiodo-3-((1-oxobutyl)amino)-
DTXSID30222096
DTXCID30144587
4-14-00-01120 (beilstein handbook reference)