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Cefuroxime

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Identification
Molecular formula
C16H16N4O8S
CAS number
55268-75-2
IUPAC name
3-(carbamoyloxymethyl)-7-[[2-(2-furyl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, cefuroxime is in a solid state in the form of a white to off-white crystalline powder.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
424.38g/mol
Molar mass
424.3840g/mol
Density
1.5000g/cm3
Appearence
Cefuroxime appears as a white to off-white crystalline powder. It is slightly soluble in water and ethanol, but freely soluble in dimethyl sulfoxide.
Comment on solubility

Solubility of 3-(carbamoyloxymethyl)-7-[[2-(2-furyl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (C16H16N4O8S)

The solubility of 3-(carbamoyloxymethyl)-7-[[2-(2-furyl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (C16H16N4O8S) can be influenced by various factors contributing to its chemical structure.

  • Polarity: This compound contains multiple functional groups that can contribute to its overall polarity, thus affecting its solubility in various solvents.
  • Hydrophilicity: The presence of carbamoyl and carboxylate moieties suggests potential hydrophilic interactions with polar solvents like water.
  • Hydrophobic parts: The furan ring and methoxy group may induce hydrophobic characteristics, potentially promoting solubility in organic solvents.
  • pH Sensitivity: The solubility may be affected by the pH of the solution, particularly because of the ionizable carboxylic group which could become deprotonated in alkaline conditions.

In conclusion, it is essential to consider the appropriate solvent system when evaluating the solubility of this complex structure. As a general rule, “like dissolves like”; therefore, a balance between polar and non-polar characteristics must be achieved to determine the optimal conditions for dissolving this compound.

Interesting facts

Interesting Facts about 3-(Carbamoyloxymethyl)-7-[[2-(2-furyl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

3-(Carbamoyloxymethyl)-7-[[2-(2-furyl)-2-methoxyimino-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is a fascinating compound with several noteworthy attributes:

  • Antibiotic Potential: This compound belongs to the class of compounds known for their antimicrobial properties, particularly those related to bacterial infections, making it a subject of interest in pharmaceutical research.
  • Complex Structure: The intricate structure of this compound includes a bicyclic framework which contributes to its biological activity. Such structures are often pivotal in drug design as they can fit well into biological targets.
  • Functional Groups: The presence of various functional groups, such as the carbamoyl and methoxyimino moieties, enhances its reactivity and potential for interacting with different biological systems.
  • Research Applications: Ongoing studies are evaluating the efficacy of this compound in treating various infections, especially those that are resistant to conventional antibiotics. This opens new avenues in tackling public health challenges.
  • Furyl Group: The inclusion of the furyl group adds a level of aromaticity to the molecular structure, which can enhance its stability and interaction with a variety of biological receptors.

As we continue to unravel the complexities of such compounds, understanding their structure-activity relationships can significantly advance the development of novel therapeutics. Research in this area exemplifies the importance of chemistry in addressing urgent medical needs and enhancing our knowledge of how molecular structures can influence health.