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Cefuroxime

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Identification
Molecular formula
C16H16N4O8S
CAS number
55268-75-2
IUPAC name
3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, cefuroxime is a solid. It is usually formulated into a lyophilized powder for reconstitution before administration. In its formulated form, it is prepared for administration by injection or infusion.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
424.39g/mol
Molar mass
424.4100g/mol
Density
1.8200g/cm3
Appearence

Cefuroxime is generally a white to off-white crystalline powder that is odorless or practically odorless. It is soluble in dimethyl sulfoxide and slightly soluble in water.

Comment on solubility

Solubility of 3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility of the compound C16H16N4O8S is an important characteristic that influences its applications in various fields. Understanding its solubility can help in determining its behavior in biological, pharmaceutical, and environmental contexts. Here are some key points to consider:

  • Solvent Dependency: The solubility of this compound may vary significantly based on the solvent used. Polar solvents such as water may show different solubility characteristics compared to organic solvents like ethanol or dichloromethane.
  • Functional Groups Influence: The presence of multiple functional groups, including carbonyls and thiazole, often enhances solubility in polar solvents, while hydrophobic moieties may limit solubility in aqueous environments.
  • pH Sensitivity: The solubility can be affected by the pH of the solution, especially if the compound contains acidic or basic groups. Changes in pH can lead to ionization, which typically enhances solubility.
  • Temperature Effects: As with many organic compounds, an increase in temperature generally increases solubility, making it easier to dissolve the compound in various solvents.
  • Concentration Limits: At higher concentrations, solubility may reach a saturation point, beyond which the compound will not dissolve further.

In summary, the solubility of C16H16N4O8S is influenced by various factors, and understanding these factors is crucial for its effective utilization in both laboratory and practical applications. It is always advisable to conduct solubility tests in specific solvents to ascertain the most suitable conditions for working with this compound.

Interesting facts

Interesting Facts about 3-(Carbamoyloxymethyl)-7-methoxy-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This compound belongs to a class of chemical entities that hold significant promise in medicinal chemistry, specifically in the field of antibiotic development. Here are some intriguing insights:

  • Complex Structure: The compound features a bicyclic structure, which is notable for its unique arrangement of atoms. Bicyclic compounds often display enhanced stability and reactivity, contributing to their versatility in synthesis and application.
  • Functional Groups: It contains various functional groups such as carbamoyl, methoxy, and thiol compounds. These groups can influence the compound's biological activity and interactions with biomolecules.
  • Biological Relevance: Compounds with similar structures have been investigated for their potential as antibacterial and antifungal agents. This suggests that the compound may be effective in combating resistant strains of bacteria.
  • Thienyl Substituent: The presence of a thienyl group is particularly interesting as it contributes to the compound's pharmacological properties. Thiophene derivatives are known for their diverse biological activities, enhancing the efficacy of the compound.
  • Potential Applications: Besides pharmaceutical uses, compounds like this can serve as building blocks for the synthesis of more complex molecules, making them valuable in organic synthesis and material science.

As you delve into the intricacies of this compound, one can appreciate the *multifaceted nature* of molecular design and the endless possibilities in the *pharmaceutical landscape*. Remember, every new compound synthesized opens a new door towards potential therapies and innovations!

Synonyms
3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
BDBM50169176
STK182586
AKOS005411678
(6R,7R)-3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7S)-3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7S)-3-Carbamoyloxymethyl-7-methoxy-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7S)-4-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6S,7R)-3-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6S,7R)-4-(carbamoyloxymethyl)-7-methoxy-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
3-Carbamoyloxymethyl-7-methoxy-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
3-Carbamoyloxymethyl-7-methoxy-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid anion
3-Carbamoyloxymethyl-7-methoxy-8-oxo-7-(2-thiophen-3-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid anion