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Thiomersal

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Identification
Molecular formula
C9H9HgNO2
CAS number
54-64-8
IUPAC name
[3-[carboxy-(2-methoxybenzoyl)amino]-2-hydroxy-propyl]mercury(1+);hydroxide
State
State

At room temperature, thiomersal exists as a solid. It is commonly found in crystalline form and is stable under normal conditions of use. The compound is slightly soluble in water but more soluble in alcohol and other organic solvents.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
404.82g/mol
Molar mass
404.8180g/mol
Density
2.4504g/cm3
Appearence

Thiomersal typically appears as a white or slightly off-white crystalline powder. It is used as an antiseptic and antifungal agent in various medical applications. Its physical state is usually in the form of a crystalline solid.

Comment on solubility

Solubility of [3-[carboxy-(2-methoxybenzoyl)amino]-2-hydroxy-propyl]mercury(1+);hydroxide

The solubility of [3-[carboxy-(2-methoxybenzoyl)amino]-2-hydroxy-propyl]mercury(1+];hydroxide can be quite complex due to its unique chemical structure. Several factors contribute to its solubility characteristics:

  • Polarity: The presence of polar functional groups such as carboxylic acids and hydroxyls enhances the potential for solvent interactions, particularly in polar solvents like water.
  • Complex Formation: Mercury compounds can often form complexes with ligands, which may influence their solubility. The ligand's properties significantly affect the overall solubility behavior.
  • pH Dependence: The solubility may vary with pH, particularly because the compound contains both acidic and basic functional groups.
  • Temperature Effects: Generally, as temperature increases, the solubility of many compounds tends to increase, but specific behavior should be experimentally determined for this compound.

It is crucial to note that while specific data on the solubility of this compound may be limited, the combination of functional groups provides a reasonable expectation of it being soluble to some degree in polar solvents. However, practical applications may necessitate empirical testing to confirm solubility in a target solvent.

Interesting facts

Exploring [3-[carboxy-(2-methoxybenzoyl)amino]-2-hydroxy-propyl]mercury(1+);hydroxide

[3-[carboxy-(2-methoxybenzoyl)amino]-2-hydroxy-propyl]mercury(1+);hydroxide is a fascinating compound with diverse applications in both medicinal chemistry and analytical chemistry. Here are some interesting insights:

Chemical Structure and Function

  • Unique Composition: This compound features an intriguing combination of mercury, hydroxy groups, and aromatic structures, which may contribute to its biological activity.
  • Mercury Coordination: The presence of mercury(1+) implies an interesting coordination environment, which can influence its reactivity and interactions with biological molecules.

Biological Relevance

  • Potential Therapeutic Uses: Compounds containing mercury have been studied for their potential use in treatment for certain diseases, albeit with caution due to mercury's toxicity.
  • Drug Development: This compound may serve as a model in the synthesis of novel pharmaceuticals, demonstrating how modifying functional groups can alter biological efficacy.

Analytical Applications

  • Analytical Chemistry: The unique characteristics of mercury compounds make them suitable for use as reagents in analytical methods, particularly in trace metal analysis.
  • Colorimetric Detection: The compound's ability to form stable complexes may enable the detection of specific analytes, enhancing the sensitivity of diagnostic tests.

In summary, [3-[carboxy-(2-methoxybenzoyl)amino]-2-hydroxy-propyl]mercury(1+);hydroxide is not only a compound of interest due to its unique chemical structure but also invites research into its potential medicinal and analytical applications. As we advance our understanding and methodologies in chemistry, compounds like this will continue to challenge and inspire scientists.

Synonyms
Mercuderamid
RefChem:1088950
Unephral
EINECS 247-796-8
Hydroxymercuripropanolamide of o-carboxyphenoxyacetic acid
(o-((2-Hydroxy-3-(hydroxymercure)propyl)carbamoyl)phenoxy)acetic acid
Acetic acid, (o-((2-hydroxy-3-hydroxymercuri)propyl)carbamoyl)phenoxy-
Mercuderamide [INN:DCF]
Mercuderamidum [INN-Latin]
Merurate(1-), (3-((2-(carboxylatomethoxy)benzoyl)amino)-2-hydroxypropyl)hydroxy-, hydrogen
UNII-1057GW1CVX
Mercuderamida [INN-Spanish]
EINECS 208-371-2
MERCURY, (3-(alpha-CARBOXY-o-ANISAMIDO)-2-HYDROXYPROPYL)HYDROXY-
Hydrogen (3-((alpha-carboxylato-o-anisoyl)amino)-2-hydroxypropyl)hydroxymercurate(1-)
Mercury, (3-((2-(carboxylatomethoxy)benzoyl)amino)-2-hydroxypropyl)hydroxy-, hydrogen
NS00127281
Mercury, (2-((2-(carboxymethoxy)benzoyl)amino)-1-hydroxyethyl)hydroxy-