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4'-Fluorochalcone

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Identification
Molecular formula
C9H6ClFO
CAS number
729-35-1
IUPAC name
3-chloro-1-(4-fluorophenyl)prop-2-en-1-one
State
State

The compound is typically found as a solid at room temperature, exhibiting a crystalline form.

Melting point (Celsius)
47.00
Melting point (Kelvin)
320.15
Boiling point (Celsius)
150.00
Boiling point (Kelvin)
423.15
General information
Molecular weight
194.59g/mol
Molar mass
194.6090g/mol
Density
1.1771g/cm3
Appearence

The compound appears as a yellow crystalline solid. It has a characteristic crystalline structure that is often observed under a microscope.

Comment on solubility

Solubility of 3-chloro-1-(4-fluorophenyl)prop-2-en-1-one

The solubility of 3-chloro-1-(4-fluorophenyl)prop-2-en-1-one in various solvents is a crucial aspect to consider for its applications and behavior. Here are some important points regarding its solubility:

  • Polar vs. Non-polar Solvents: This compound may exhibit varying solubility in polar and non-polar solvents due to its structural characteristics. Typically, compounds with halogen substituents, such as chlorine and fluorine, may show higher solubility in less polar organic solvents.
  • Water Solubility: The presence of the chloro and fluoro groups can influence its interaction with water, often leading to low solubility. Compounds with such halogen substituents generally have limited solubility in water due to their hydrophobic nature.
  • Solvent Compatibility: It is advisable to test solubility in common solvents like ethanol, acetone, and DMSO to determine its effective use in different chemical reactions and formulations.

As a general observation, the solubility behavior of 3-chloro-1-(4-fluorophenyl)prop-2-en-1-one can be described as:

  1. Moderate to low solubility in water.
  2. Potentially good solubility in organic solvents.
  3. Dependent on the presence of functional groups and overall molecular structure.

In summary, understanding the solubility of 3-chloro-1-(4-fluorophenyl)prop-2-en-1-one is essential for predicting its behavior in various chemical environments and optimizing its use in synthetic applications.

Interesting facts

Interesting Facts about 3-Chloro-1-(4-Fluorophenyl)prop-2-en-1-one

3-Chloro-1-(4-fluorophenyl)prop-2-en-1-one is a fascinating compound known for its unique structure and potential applications in various fields. Here are some compelling aspects to consider:

  • Structural Features: This compound features a conjugated system characterized by a double bond in the prop-2-en-1-one moiety, which contributes to its reactivity.
  • Fluorine Influence: The presence of the fluorine atom on the phenyl ring can significantly affect the compound's chemical properties, enhancing its lipophilicity and altering its interactions with biological systems.
  • Applications: Thanks to its distinct structure, 3-chloro-1-(4-fluorophenyl)prop-2-en-1-one is frequently studied for potential applications in pharmaceuticals, particularly as intermediates in the synthesis of bioactive molecules.
  • Biological Activity: Compounds with similar structures have been identified as possessing various biological activities, including antimicrobial and anti-inflammatory properties, making this compound of interest in medicinal chemistry.
  • Reactivity Studies: The double bond makes this compound reactive towards electrophiles, facilitating a variety of chemical reactions that are instrumental in synthetic organic chemistry.

In summary, 3-chloro-1-(4-fluorophenyl)prop-2-en-1-one serves as an intriguing subject for further research, offering insights into the development of novel compounds with significant biological potential. As its study progresses, we may uncover even more about its role in both chemistry and industry.

Synonyms
(E)-beta-Chloro-4'-fluoroacrylophenone
SCHEMBL9798239