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3-Chloro-4-fluoroaniline

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Identification
Molecular formula
C6H5ClFN
CAS number
367-21-5
IUPAC name
3-chloro-4-fluoro-aniline
State
State

At room temperature, 3-Chloro-4-fluoroaniline is typically a solid, crystallizing in form with a slightly translucent appearance. It maintains its solid state under standard conditions unless exposed to temperatures nearing its melting point.

Melting point (Celsius)
49.00
Melting point (Kelvin)
322.15
Boiling point (Celsius)
218.00
Boiling point (Kelvin)
491.15
General information
Molecular weight
145.56g/mol
Molar mass
143.5580g/mol
Density
1.3980g/cm3
Appearence

3-Chloro-4-fluoroaniline is a light yellow to amber solid with a distinctive aromatic odor. It usually forms as crystalline or powdery substances, often appearing somewhat glossy under light reflecting conditions.

Comment on solubility

Solubility of 3-chloro-4-fluoro-aniline

3-chloro-4-fluoro-aniline, with the chemical formula C6H5ClF2, exhibits interesting solubility characteristics relevant for various applications in chemical processes.

When considering the solubility of this compound, it's essential to note the following factors:

  • Polarity: The presence of both chloro (–Cl) and fluoro (–F) groups increases the polarity of the molecule, which can enhance its solubility in polar solvents.
  • Solvent Compatibility: 3-chloro-4-fluoro-aniline generally shows moderate solubility in common organic solvents like ethanol and acetone, while being less soluble in non-polar solvents.
  • pH Influence: The solubility can change with pH, particularly due to the amino group which can become protonated in acidic conditions, potentially increasing solubility in such environments.
  • Temperature Effects: Like many organic molecules, solubility may increase with temperature due to enhanced molecular activity.

In summary, the solubility of 3-chloro-4-fluoro-aniline is influenced by its polarity, solvent choice, pH levels, and temperature. Understanding these factors can aid in optimizing its use in various chemical processes and applications.

Interesting facts

3-Chloro-4-fluoro-aniline: An Insight into a Versatile Compound

3-Chloro-4-fluoro-aniline is a fascinating aromatic amine that showcases the intriguing chemistry behind halogenated compounds. This compound possesses unique properties due to the presence of both chlorine and fluorine substituents on its aniline ring, which contribute to its chemical reactivity and applications in various fields.

Key Features and Applications

  • Pharmaceuticals: The substitution of chlorine and fluorine in 3-chloro-4-fluoro-aniline can influence its biological activity, making it a valuable intermediate in the synthesis of various pharmaceuticals. Its derivatives often find applications in drug development.
  • Agricultural Chemicals: This compound is also significant in the agricultural industry, where it can be used as a building block for herbicides and pesticides, helping to enhance crop protection and yield.
  • Material Science: The unique electronic effects of halogens might improve the stability or performance of materials, leading to innovations in polymer chemistry and coatings.

Chemical Reactivity

3-Chloro-4-fluoro-aniline exhibits distinct chemical reactivity due to its electron-withdrawing halogen groups. This can lead to:

  • **Nucleophilic substitution** reactions, allowing for further modifications and the creation of new compounds.
  • **Electrophilic aromatic substitution**, making it a good substrate for the introduction of other functional groups, thus paving the way for complex compound synthesis.

Interesting Tidbits

Here are some compelling aspects of 3-chloro-4-fluoro-aniline that underscore its significance in chemistry:

  • It's often studied in medicinal chemistry due to its potential therapeutic applications.
  • The intricate balance of halogens alters the compound's interaction with biological systems, which can be beneficial for targeted drug design.
  • Researchers are exploring its properties in the realm of organic electronics, specifically in the development of organic light-emitting diodes (OLEDs).

In summary, 3-chloro-4-fluoro-aniline exemplifies the intricate connections between molecular structure, reactivity, and application. As you delve deeper into the world of compounds like this, you will discover the profound impact that even small chemical modifications can make in various scientific fields!

Synonyms
3-CHLORO-4-FLUOROANILINE
367-21-5
3-Chloro-4-fluorobenzenamine
Benzenamine, 3-chloro-4-fluoro-
Aniline, 3-chloro-4-fluoro-
3-Chloro-4-fluorophenylamine
4-FLUORO-3-CHLOROANILINE
3-chloro-4-fluoro aniline
3-chloro-4-fluoro-aniline
UNII-7L63CC70UQ
MFCD00007767
7L63CC70UQ
EINECS 206-682-8
NSC 10290
NSC-10290
M-CHLORO-P-FLUOROANILINE
3-Chloro-4-fluoroaniline(Chunks or pellets)
DTXSID0038754
3-chloro-4-fluoro-phenylamine
Gefitinib Impurity V
3-chloro4-fluoroaniline
Norfloxacin Intermediates
3-Chloro-4-fluoroanilin
3-chloro-4-flouroaniline
3-chloro4-fluoro-aniline
4-fluoro-3-chloro-aniline
SCHEMBL9602
3chloro-4-fluoro-phenylamine
4-fluoro-3-chlorophenylamine
4-fluoro-3-chlorophenyl amine
4-fluoro-3-chloro phenyl amine
DTXCID8018754
3-Chloro-4-fluoroaniline, 98%
BCP26715
HY-Y0680
NSC10290
STL164339
AKOS000119505
AC-2469
CS-W009142
FC34831
PS-8955
SB00006
DB-023935
NS00041709
EN300-20338
A15531
P19616
AG-617/02198034
Q27268500
F2190-0461
Z104477780
3-Chloro-4-fluoroaniline;Benzenamine, 3-chloro-4-fluoro-
206-682-8