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Scopolamine hydrobromide

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Identification
Molecular formula
C17H24ClFNO2 · HBr
CAS number
114-49-8
IUPAC name
(3-chloro-4-fluoro-phenyl)methyl-(1,7,7-trimethylnorbornan-2-yl)ammonium;bromide
State
State

At room temperature, Scopolamine hydrobromide exists in a solid state. The compound maintains its solid form under standard conditions but can readily dissolve in water and some organic solvents.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
438.36g/mol
Molar mass
438.3630g/mol
Density
1.3220g/cm3
Appearence

Scopolamine hydrobromide appears as a crystalline white solid. The compound may absorb moisture from the air, becoming slightly sticky when exposed to humidity. Its appearance is consistent with many hydrobromide salts, generally exhibiting a fine, powdery texture when dry.

Comment on solubility

Solubility Characteristics

The compound (3-chloro-4-fluoro-phenyl)methyl-(1,7,7-trimethylnorbornan-2-yl)ammonium bromide exhibits interesting solubility properties due to its unique molecular structure. Let's explore its solubility:

  • Polar Nature: The presence of the ammonium group contributes to the compound being relatively polar, potentially enhancing solubility in polar solvents such as water.
  • Bromide Ion: As a bromide salt, it may dissociate in solution, wherein the bromide ion (Br-) could facilitate solubility.
  • Hydrophobic Components: The bulky norbornane moiety introduces hydrophobic characteristics that can limit solubility in very polar solvents, suggesting a potential preference for organic solvents.
  • Temperature Influence: Solubility may increase with temperature, which is typical for many ionic compounds, as solubility often improves with added heat.

Overall, while the compound showcases potential solubility in polar environments due to its ionic nature, the balance of hydrophilic and hydrophobic groups within its structure hints at varying solubility profiles depending on the solvent system used. Therefore, it is essential to consider both the molecular interactions and the solvent properties when evaluating its solubility.

Interesting facts

Interesting Facts about (3-Chloro-4-Fluoro-Phenyl)Methyl-(1,7,7-Trimethylnorbornan-2-Yl)Ammonium Bromide

This compound represents a fascinating intersection of organic chemistry and materials science. It is characterized by its unique structural features, incorporating elements that may suggest a variety of applications in fields such as medicinal chemistry, materials science, and possibly even chemical synthesis. Here are some compelling aspects to consider:

  • Ammonium Ion Diversity: The presence of the ammonium group adds distinctive properties that can impact both solubility and the interaction with biological systems. Ammonium compounds are often found in drug design due to their positive charge, which can enhance binding affinities.
  • Fluorine as a Game Changer: The incorporation of fluorine atoms, specifically in the phenyl ring, can lead to increased lipophilicity, which is critical for the absorption and distribution of pharmaceuticals in the body. Fluorine is known to modify the electronic properties of the molecule.
  • Norbornane Framework: The use of a norbornane skeleton introduces a level of strain that can affect reaction mechanisms and stability. Such frameworks are common in organic synthesis and facilitate the development of novel reagents and catalysts.
  • Selectivity and Potency: The structural complexity of this compound opens the door to high selectivity in biological applications. This may result in lower dosages required for pharmacological effects, minimizing side effects, which is a significant consideration in drug development.
  • Potential for Research: Compounds of this type are often used in exploratory research toward creating new materials or drugs, presenting opportunities for innovations in treatment methodologies for diseases.

As with many promising compounds in organic chemistry, the specificity of the interactions and the subtleties of their behavior in various environments make them subjects of ongoing research. Understanding the roles played by each component in (3-chloro-4-fluoro-phenyl)methyl-(1,7,7-trimethylnorbornan-2-yl)ammonium bromide could yield invaluable insights into its potential uses. Remember, in science, "the only constant is change." Each experiment provides more data, leading us closer to surprising discoveries!

Synonyms
(+-)-endo-N-(3-Chloro-4-fluorobenzyl)-2-bornanamine hydrobromide
24629-66-1
2-BORNANAMINE, N-(3-CHLORO-4-FLUOROBENZYL)-, HYDROBROMIDE, endo-(+-)-
RefChem:256676