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3-Chloro-4-methoxyaniline

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Identification
Molecular formula
C7H8ClNO
CAS number
120-85-4
IUPAC name
3-chloro-4-methoxy-aniline
State
State
Solid at room temperature.
Melting point (Celsius)
73.00
Melting point (Kelvin)
346.15
Boiling point (Celsius)
282.00
Boiling point (Kelvin)
555.15
General information
Molecular weight
157.60g/mol
Molar mass
157.5980g/mol
Density
1.2690g/cm3
Appearence

3-Chloro-4-methoxyaniline typically appears as an off-white to beige solid. It is a crystalline substance that may darken upon exposure to air or light. The compound is usually provided in powder or crystallized form for laboratory uses.

Comment on solubility

Solubility of 3-chloro-4-methoxy-aniline

3-chloro-4-methoxy-aniline, a member of the aniline family, exhibits unique solubility characteristics that make it particularly interesting for various applications. This compound is moderately soluble in water but demonstrates a more favorable solubility in organic solvents. Here are some key points to consider:

  • Aqueous Solubility: The presence of both a chlorine atom and a methoxy group can affect the intermolecular interactions with water. Thus, while it is not highly soluble, it can dissolve to a limited extent, allowing for some utility in aqueous solutions.
  • Solubility in Organic Solvents: 3-chloro-4-methoxy-aniline is often more soluble in polar organic solvents such as ethanol, methanol, and acetone. This can be attributed to the compatibility of its molecular structure with these solvents.
  • Impact of pH: The solubility of this compound may also vary with pH changes. Under acidic conditions, protonation of the amino group can enhance solubility in aqueous environments.

Overall, the solubility profile of 3-chloro-4-methoxy-aniline is a balance of its hydrophilic and hydrophobic properties, making it a versatile compound in organic and medicinal chemistry. Understanding these solubility dynamics is crucial for its effective use in laboratory and industrial settings.

Interesting facts

Exploring 3-Chloro-4-methoxy-aniline

3-Chloro-4-methoxy-aniline, a fascinating aromatic amine, belongs to a class of compounds known for their versatile applications in various fields such as pharmaceuticals, materials science, and dye production. Here are some intriguing facts that distinguish this compound:

  • Structure and Reactivity: The presence of both a chloro group and a methoxy group on the benzene ring significantly influences its chemical reactivity. Such substitutions can enhance the compound's nucleophilicity, making it a key player in various organic synthesis reactions.
  • Pharmaceutical Importance: As a derivative of aniline, 3-chloro-4-methoxy-aniline has garnered attention in medicinal chemistry. It can serve as an essential building block for developing pharmaceuticals, particularly in the treatment of various ailments.
  • Dyes and Pigments: Alkoxy-substituted anilines like this compound are often utilized in dye chemistry. Their unique structural properties enable them to be transformed into vibrant dyes used in textile and pigment industries.
  • Biological Activity: Some studies suggest that anilines and their derivatives can exhibit antimicrobial properties, making this compound potentially valuable in the development of new antibacterial agents.
  • Environmental Consideration: As with many chemical compounds, it is essential to consider the environmental impact of 3-chloro-4-methoxy-aniline. Its stability and reactivity in various environmental matrices can have implications for ecological systems, which makes ongoing research critical.

In summary, 3-chloro-4-methoxy-aniline stands out not just as an ordinary chemical compound but as a vital player in scientific research and application. Understanding its properties and potential uses opens new avenues for innovation in chemistry and related fields.

Synonyms
3-CHLORO-4-METHOXYANILINE
5345-54-0
2-Chloro-4-anisidine
EINECS 226-298-4
BRN 0879162
O-chloro-p-anisidine
XQVCBOLNTSUFGD-UHFFFAOYSA-
DTXSID00201616
3-13-00-01180 (Beilstein Handbook Reference)
3-Cl-4-MetAN
DTXCID30124107
inchi=1/c7h8clno/c1-10-7-3-2-5(9)4-6(7)8/h2-4h,9h2,1h3
xqvcbolntsufgd-uhfffaoysa-n
3-Chloro-p-anisidine
Benzenamine, 3-chloro-4-methoxy-
2-Chloro-4-aminoanisole
p-Anisidine, 3-chloro-
3-Chloroanisidine
3-Chloro-4-methoxybenzenamine
OCPA
Orthochloroparanisidine
3-Chloro-para-anisidine (NH2=1)
NSC 1706
MFCD00007771
QKF2V8L8PC
NSC-1706
3-Chloro-para-anisidine [NH2=1]
3-Chloro-4-methoyaniline
3-Chloro-4-methoxy-phenylamine
3-chloro-4-methoxy-aniline
3-chloro-4-methoxyphenylamine
3-chloro4-methoxyaniline
UNII-QKF2V8L8PC
3-chloro 4-methoxyaniline
3-chlor-4-methoxy-aniline
3-chloro-4-methoxy aniline
4-methoxy-3-chloro-aniline
SCHEMBL77110
3-chloro-4-(methyloxy)aniline
NSC1706
CHEBI:194651
3-Chloro-4-methoxyaniline, 97%
STR02109
CL8418
STL169149
AKOS000101739
AC-5994
PS-4454
DB-011166
A7780
NS00032764
EN300-20321
F2190-0507
Z104477738