Clonazepam | Solubility of Things

Identification

Molecular formula

C₁₆H₁₃ClN₂O

CAS number

1622-61-3

IUPAC name

3-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one

State

At room temperature, clonazepam is in the form of a solid crystalline powder. It is typically used in formulated pharmaceuticals.

Melting point (Celsius)

239.50

Melting point (Kelvin)

512.65

Boiling point (Celsius)

415.20

Boiling point (Kelvin)

688.35

General information

Molecular weight

315.71g/mol

Molar mass

343.1640g/mol

Density

1.5000g/cm³

Appearence

Clonazepam is a light yellow crystalline powder. It has no odor. The compound is typically processed and formulated into tablets or liquids for pharmaceutical use.

Comment on solubility

Solubility of 3-Chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one

The solubility of 3-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one can be characterized by several key factors. Understanding its solubility is crucial for its application and effectiveness in various contexts.

Factors Influencing Solubility

Polarity: The presence of both polar and non-polar functional groups plays a significant role in determining solubility in different solvents.
Hydrogen Bonding: The ability of the compound to form hydrogen bonds can enhance solubility in polar solvents.
Molecular Size: Larger molecules may exhibit decreased solubility due to steric hindrance.

In general:

It tends to be more soluble in polar solvents, such as water or alcohols, due to the interaction of its nitrogen and chloro groups.

Solubility in non-polar solvents may be limited, as the presence of hydrophobic regions within the molecule may hinder dissolution.

To summarize, the solubility of 3-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one is a complex interplay of structural characteristics and solvent properties, making it essential to conduct thorough solubility tests in practical applications. As a general rule of thumb, "like dissolves like," meaning it is more likely to dissolve in solvents with similar polarity.

Interesting facts

Interesting Facts about 3-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one

The compound 3-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one is a fascinating member of the benzodiazepine family, which is widely recognized for its psychoactive properties. Here are some intriguing insights regarding this compound:

Pharmacological Importance: Like many benzodiazepines, this compound may exhibit anxiolytic, sedative, and muscle-relaxing effects, making it of particular interest in medicinal chemistry and pharmacology.

Structural Complexity: The presence of a chloro group, coupled with a dimethylaminoethyl side chain, enhances its chemical reactivity and may influence its interaction with biological targets.

Potential Applications: Compounds with similar structures have been explored in the context of treating anxiety disorders and sleep disturbances. Research is ongoing to understand its efficacy and safety profile.

Synthetic Pathways: The synthesis of this compound likely involves intricate multi-step reactions, showcasing the creativity and skill required in organic chemistry.

Mechanism of Action: Benzodiazepines typically function by modulating the GABA^A receptor, promoting inhibitory neurotransmission in the central nervous system, which is a crucial pathway in managing anxiety and related conditions.

As we delve deeper into the characteristics of 3-chloro-5-[2-(dimethylamino)ethyl]-11-methyl-benzo[b][1,4]benzodiazepin-6-one, we unveil the mysteries of chemical bonding and biological interaction. It stands as a testament to the incredible intricacies of pharmaceuticals and the ongoing quest to develop effective therapeutic agents.