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Olanzapine

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Identification
Molecular formula
C17H20ClN3OS
CAS number
132539-06-1
IUPAC name
3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
State
State

At room temperature, Olanzapine is a solid. It is most frequently encountered in its commercial tablet form, which is used for oral administration.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.15
Boiling point (Celsius)
499.45
Boiling point (Kelvin)
772.60
General information
Molecular weight
312.83g/mol
Molar mass
312.4390g/mol
Density
1.2900g/cm3
Appearence

Olanzapine is typically provided as a yellow crystalline powder. It can appear as tablet form and may also be administered in injectable form. The powder is slightly soluble in water.

Comment on solubility

Solubility of 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

The solubility of the compound 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine (C17H20ClN3OS) is influenced by various factors, including its molecular structure and the presence of polar functional groups. Here are some key points related to its solubility:

  • Polar and Nonpolar Characteristics: The presence of a chlorine atom and a piperazine ring may impart some polarity to the molecule, which could enhance its solubility in polar solvents such as water or alcohols.
  • Solvent Types: This compound may show greater solubility in organic solvents such as DMSO (dimethyl sulfoxide) or methanol, while potentially exhibiting lower solubility in nonpolar solvents like hexane.
  • Hydrogen Bonding: The ability of the compound to engage in hydrogen bonding could further affect its solubility profile, possibly increasing compatibility with solvents that can donate or accept hydrogen bonds.

In conclusion, while the precise solubility data might require empirical testing, the structural characteristics of C17H20ClN3OS suggest a multifaceted solubility behavior that is worth exploring further in relevant solvent systems.

Interesting facts

Interesting Facts about 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine

3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine is a fascinating compound belonging to the benzodiazepine class, known for its myriad of pharmacological effects. Here are some intriguing insights into this compound:

  • Pharmacological Activity: This compound exhibits a range of pharmacological actions, primarily focusing on its potential as an anxiolytic, sedative, and muscle relaxant. Its unique structure allows it to interact effectively with the central nervous system.
  • Chemical Structure: The incorporation of a piperazine moiety in its framework is significant. This part of the structure enhances the compound’s ability to stabilize and modulate neurotransmitter systems, specifically involving GABAA receptors.
  • Research Origin: The compound stemmed from ongoing research into the development of new therapeutic agents aimed at treating anxiety and related disorders. It exemplifies the diverse approaches chemists utilize in drug discovery.
  • Synthetic Pathways: Its synthesis involves multi-step reactions, often employing chlorination and piperazine derivatization. This complexity reflects the challenges faced in drug development, making each step crucial for achieving the desired efficacy and safety profiles.
  • Potential Applications: Beyond anxiety reduction, compounds of this class are being investigated for their neuroprotective properties. Studies are underway to explore whether modifications, like those seen in 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine, can lead to breakthroughs in treating neurodegenerative diseases.

As a chemist or a student of chemistry, understanding such compounds not only enhances knowledge of their properties and potential uses but also stimulates curiosity about how structural variations can lead to different biological activities. In the words of a famous chemist, "Chemistry is the art of problem-solving." The study of compounds like 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine is a prime example of this artistry in action.