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Olanzapine

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Identification
Molecular formula
C17H20ClN3OS
CAS number
132539-06-1
IUPAC name
3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine
State
State

Olanzapine appears as a solid at room temperature. It is usually handled in powder form for pharmaceutical use.

Melting point (Celsius)
195.50
Melting point (Kelvin)
468.70
Boiling point (Celsius)
518.50
Boiling point (Kelvin)
791.70
General information
Molecular weight
312.83g/mol
Molar mass
312.4430g/mol
Density
1.3199g/cm3
Appearence

Olanzapine is a pale yellow solid. It is usually found as a crystalline powder that might have a subtle odor.

Comment on solubility

Solubility of 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine (C17H20ClN3OS)

The solubility of 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine is an important aspect to consider for its applications and behavior in different environments. This compound showcases a unique solubility profile that can be influenced by several factors, including:

  • Polarity: The presence of chlorine and piperazine within the structure increases its polar character, which can aid in solubility in polar solvents.
  • Hydrogen bonding: The functional groups in the compound are capable of engaging in hydrogen bonding, enhancing its interaction with polar solvents, such as water.
  • Temperature: Solubility can vary with temperature, where increased temperature typically leads to higher solubility in many cases.

While comprehensive data on the exact solubility of this specific benzodiazepine derivative may not be extensively documented, general trends can be inferred:

  1. Generally Soluble: This compound may exhibit good solubility in organic solvents like dimethyl sulfoxide (DMSO) or ethanol.
  2. Limited Water Solubility: Given its complex ring structure, it is likely to have limited solubility in water.

It is essential to consider the solubility of 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine in the context of its desired application, as solubility can significantly influence pharmacokinetics and bioavailability. As with many pharmaceuticals, optimal solubility may be achieved through formulations or co-solvents that enhance its availability in biological systems.

Interesting facts

Exploring 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine

3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine (commonly referred to as a derivative of the benzodiazepine class) offers a fascinating insight into both medicinal chemistry and pharmacology. This compound showcases characteristics that are particularly intriguing for researchers focused on drug design and therapeutic applications.

Interesting Facts:

  • Benzodiazepine Family: As a member of the benzodiazepine class, this compound is noteworthy for its potential effects on the central nervous system. Benzodiazepines are widely recognized for their anxiolytic, sedative, and muscle relaxant properties.
  • Piperazine Incorporation: The incorporation of a piperazine group is significant, as it enhances the pharmacological profile of the compound. Piperazine derivatives are known to improve receptor binding and target specificity.
  • Chlorine Influence: The presence of a chlorine atom (specifically at the 3-position) can modulate the compound's lipophilicity, potentially influencing its distribution, metabolism, and excretion in biological systems.
  • Research Applications: This compound is of interest in the development of new medications, particularly in treating anxiety disorders, schizophrenia, and other neuropsychiatric conditions, given its structural similarities with existing therapeutic agents.
  • Scientific Investigations: Studies exploring similar benzodiazepine derivatives contribute to understanding their mechanism of action, including their interaction with GABAA receptors, which play a crucial role in inhibitory neurotransmission in the brain.

In summary, 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine stands as an important compound in medicinal chemistry. With its remarkable structure and potential therapeutic uses, it opens doors for further research and application in the field of pharmacology. As we continue to explore such compounds, we gain invaluable insights into the intricacies of drug development and the science behind mental health treatments.