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3-chloro-N-(2-phenylethyl)propanamide

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Identification
Molecular formula
C11H14ClNO
CAS number
59267-79-3
IUPAC name
3-chloro-N-(2-phenylethyl)propanamide
State
State

At room temperature, 3-chloro-N-(2-phenylethyl)propanamide is typically found in a solid state, which is characteristic of many organic compounds with similar molecular weights and structures.

Melting point (Celsius)
59.20
Melting point (Kelvin)
332.40
Boiling point (Celsius)
305.30
Boiling point (Kelvin)
578.50
General information
Molecular weight
211.69g/mol
Molar mass
211.7030g/mol
Density
1.1283g/cm3
Appearence

The compound 3-chloro-N-(2-phenylethyl)propanamide typically appears as a white to off-white solid. It is usually crystalline in nature.

Comment on solubility

Solubility of 3-chloro-N-(2-phenylethyl)propanamide

The solubility of 3-chloro-N-(2-phenylethyl)propanamide in various solvents can be categorized by considering its structural features and polar characteristics. Understanding its solubility behavior is crucial for applications in chemical synthesis and pharmaceutical formulations.

Key Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups, such as the amide group, can enhance solubility in polar solvents like water.
  • Chlorine Substitution: The 3-chloro substituent may introduce some hydrophobic character, which can influence its ability to dissolve in non-polar solvents.
  • Hydrophobic Phenyl Group: The phenyl ring contributes to non-polar characteristics, impacting solubility in aqueous solutions.

Generally, amides tend to be soluble in polar solvents; however, due to the bulky phenyl group and chlorinated substituent, solubility might be limited. Common observations for this compound include:

  1. Higher solubility in organic solvents such as ethanol and acetone.
  2. Moderate solubility in water, potentially requiring higher temperatures or the presence of co-solvents.
  3. Limited solubility in non-polar solvents, making it less favorable for certain applications.

In summary, while the solubility of 3-chloro-N-(2-phenylethyl)propanamide can be predicted by its molecular structure, actual solubility should be determined experimentally for precise applications since it can vary based on conditions such as temperature and solvent composition.

Interesting facts

Interesting Facts about 3-Chloro-N-(2-phenylethyl)propanamide

3-Chloro-N-(2-phenylethyl)propanamide is a unique chemical compound that captivates the interest of both organic chemists and pharmacologists. Here are some engaging insights about this compound:

  • Functional Group Variety: This compound belongs to the amide class, distinguished by the presence of a carbonyl group linked to a nitrogen atom. The incorporation of the aromatic phenylethyl group adds complexity to its structure, influencing its reactivity and interactions.
  • Potential Biological Activity: Compounds containing amide linkages are often found in bioactive molecules. It is noted that derivatives of such amides may exhibit interesting biological properties, including anti-inflammatory and analgesic effects.
  • Synthesis and Applications: The synthesis of 3-chloro-N-(2-phenylethyl)propanamide can involve several methods in organic chemistry, showcasing the versatility of synthetic techniques. Its applications may extend into medicinal chemistry, where it can serve as a scaffold for drug development initiatives.
  • Substituent Effects: The presence of the Cl (chlorine) substituent is notable. Chlorination often alters the electronic properties of compounds, affecting how they interact with biological targets. This can make the compound a focal point in studies geared toward developing novel pharmaceuticals.
  • Reactivity: As an amide, it may undergo hydrolysis and other reactions characteristic of functional groups that can be further explored for synthetic innovation.

In summary, 3-chloro-N-(2-phenylethyl)propanamide epitomizes the fascinating interplay between structure and function in organic chemistry. The potential for biological activity and its applications in drug development make it a compound worth studying in greater detail for future scientific exploration.

Synonyms
Fenaclon
306-20-7
Fenaclonum
3-Chloro-N-(2-phenylethyl)propanamide
Phenacon
Fenakon
Phenacone
Fenaclon [INN]
Fenaclone
3-Chloro-N-phenethylpropionamide
Fenaclona
Fenaclone [INN-French]
Fenaclonum [INN-Latin]
Fenaclona [INN-Spanish]
N-(2-Phenethyl)-3-chloropropionamide
3-Chloro-N-phenethyl-propionamide
Propanamide, 3-chloro-N-(2-phenylethyl)-
UNII-6M4IR9QY13
BRN 2939383
6M4IR9QY13
DTXSID0057708
DTXCID8031497
PROPIONAMIDE, 3-CHLORO-N-(PHENETHYL)-
4-12-00-02464 (Beilstein Handbook Reference)
Propionamide, 3-chloro-N-phenethyl-
.beta.-Chloro-N-phenethylpropionamide
.beta.-Chloropropio-N-phenylethylamide
Fenaclone (INN-French)
Fenaclonum (INN-Latin)
Fenaclona (INN-Spanish)
SCHEMBL2109480
CHEMBL2106620
beta-Chloro-N-phenethylpropionamide
AAA30620
beta-Chloropropio-N-phenylethylamide
HY-B1097
Tox21_113856
AKOS000144721
CCG-213905
CS-4686
NCGC00253738-01
3-Chloro-N-(2-phenylethyl)propanamide #
CAS-306-20-7
TS-09849
NS00120407
EN300-57073
VU0549352-1
G22280
AB01563363_01
Propanamide, 3-chloro-N-(2-phenylethyl)-(9CI)
SR-01000944265
SR-01000944265-1
BRD-K08791496-001-01-0
Q27265137
F9995-0372
Z240089880