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3-(Chloromethyl)pyridine

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Identification
Molecular formula
C6H6ClN
CAS number
999-81-5
IUPAC name
3-(chloromethyl)pyridine
State
State

3-(Chloromethyl)pyridine is a liquid at room temperature. It is typically handled in liquid form during chemical synthesis and manufacturing processes.

Melting point (Celsius)
-20.00
Melting point (Kelvin)
253.15
Boiling point (Celsius)
186.00
Boiling point (Kelvin)
459.15
General information
Molecular weight
127.57g/mol
Molar mass
127.5700g/mol
Density
1.1226g/cm3
Appearence

3-(Chloromethyl)pyridine appears as a clear, colorless to pale yellow liquid. It may be slightly oily in texture. The liquid is typically water-like in appearance but may have slight coloration due to impurities or oxidation.

Comment on solubility

Solubility of 3-(chloromethyl)pyridine

3-(chloromethyl)pyridine, also known as 3-chloromethylpyridine, exhibits notable solubility characteristics that are essential to understand for its applications. This compound is a pyridine derivative, which influences its interaction with solvents significantly.

  • Polar Solvents: Due to the presence of both the chloromethyl group and the pyridine ring, 3-(chloromethyl)pyridine is generally soluble in polar solvents such as water, methanol, and ethanol.
  • Non-Polar Solvents: While it is primarily soluble in polar solvents, it also shows limited solubility in non-polar solvents like hexane or toluene, illustrating its intermediate polarity.

It is noteworthy that the specific solubility can vary depending on temperature and the presence of other solutes. As a general guideline, the solubility of 3-(chloromethyl)pyridine increases with temperature, a property beneficial in various chemical synthesis reactions. Overall, understanding the solubility profile of this compound is crucial for predicting its behavior in different chemical environments.

Interesting facts

Interesting Facts about 3-(Chloromethyl)pyridine

3-(Chloromethyl)pyridine is a fascinating organic compound that presents a unique structure and a variety of applications, especially in the fields of organic chemistry and medicinal chemistry. Here are some intriguing aspects of this compound:

  • Structural Significance: The presence of a chloromethyl group at the 3-position of the pyridine ring makes this compound particularly reactive and allows for various synthetic modifications, leading to the development of numerous derivatives.
  • Versatile Intermediary: Due to its functional group, 3-(chloromethyl)pyridine serves as an important intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals.
  • Pharmacological Potential: Compounds based on pyridine rings, including this one, have demonstrated a wide range of biological activities. They are often examined for their potential as anti-inflammatory, anti-cancer, or antimicrobial agents.
  • Reactivity: This compound can participate in several chemical reactions, such as nucleophilic substitution and coupling reactions, which make it valuable in constructing complex organic molecules.
  • Research Applications: In the realm of materials science, 3-(chloromethyl)pyridine is explored for its ability to form polymers or grafts, enhancing the functionality of various materials.

In summary, 3-(chloromethyl)pyridine is not just a chemical compound; it is a gateway to discovering new pharmaceutical agents and advanced materials. Its structural features and reactivity make it a worthwhile subject of study for chemists looking to innovate in the synthesis of complex molecules.

Synonyms
3-(Chloromethyl)pyridine
3099-31-8
3-Picolyl chloride
3-Pyridylmethyl chloride
PYRIDINE, 3-(CHLOROMETHYL)-
beta-Picoline chloride
alpha-Chloro-3-picoline
3-Picoline, alpha-chloro-
.beta.-Picoline chloride
UNII-8QM5JL9CFT
8QM5JL9CFT
BRN 0107714
.alpha.-Chloro-3-picoline
3-Picoline, .alpha.-chloro-
DTXSID7043825
5-20-05-00534 (Beilstein Handbook Reference)
INDINAVIR SULFATE IMPURITY F [EP IMPURITY]
INDINAVIR SULFATE IMPURITY F (EP IMPURITY)
3-ClMeP
DTXCID5023825
cnqcwyfdiqsalx-uhfffaoysa-n
nicotinyl chloride
3-chloromethylpyridine
3-picolylchloride
3-(chloromethyl)-pyridine
3picolylchloride
3-chlormethyl-pyridin
3-chloromethyl-pyridine
SCHEMBL17432
CHEMBL3303788
ALBB-005975
STK500350
AKOS000270711
AB01984
SB54185
NCGC00249217-01
NCGC00249217-02
DB-021701
CS-0450840
EN300-34426
AB01334617-02
Q27270905