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3-Chloropyridine

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Identification
Molecular formula
C5H4ClN
CAS number
626-60-8
IUPAC name
3-chloropyridine
State
State

3-Chloropyridine is a liquid at room temperature. Due to its liquid state, it is often handled in containers that protect it from light and moisture to prevent degradation or discoloration.

Melting point (Celsius)
-30.00
Melting point (Kelvin)
243.15
Boiling point (Celsius)
172.00
Boiling point (Kelvin)
445.15
General information
Molecular weight
113.55g/mol
Molar mass
113.5500g/mol
Density
1.2219g/cm3
Appearence

3-Chloropyridine is a colorless or pale yellow liquid with a characteristic pyridine-like odor. It tends to darken upon exposure to light, becoming brownish over time. Its clear liquid form is often used in various organic synthesis processes.

Comment on solubility

Solubility of 3-chloropyridine

3-chloropyridine, with the chemical formula C5H4ClN, displays interesting solubility characteristics that are important for its applications in various fields. Here are some key points regarding its solubility:

  • Solvent Compatibility: 3-chloropyridine is polar due to the presence of the electronegative chlorine atom. As a result, it is readily soluble in polar solvents such as:
    • Water
    • Methanol
    • Acetone
  • Limited Solubility in Non-Polar Solvents: In contrast, its solubility in non-polar solvents like hexane is significantly lower, which is typical for polar solutes.
  • Temperature Dependence: Like many organic compounds, the solubility of 3-chloropyridine can change with temperature. Typically, the solubility increases as the temperature rises.

In conclusion, the solubility behavior of 3-chloropyridine is influenced by its polarity and the nature of the solvent. As a polar compound, it is best suited for use in polar environments, making it valuable in various chemical syntheses and applications.

Interesting facts

Interesting Facts about 3-Chloropyridine

3-Chloropyridine is an intriguing compound that belongs to the family of heterocyclic aromatic compounds, specifically pyridines, which are characterized by the presence of a nitrogen atom in a six-membered ring. This unique structure imparts a variety of interesting properties and applications:

  • Versatile Chemical Building Block: 3-Chloropyridine is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its chlorine atom enhances its reactivity, making it an important precursor in the synthesis of more complex molecules.
  • Key Role in Medicinal Chemistry: This compound has been investigated for its potential role in developing new medications, particularly in the fields of anti-microbial and anti-cancer agents. Its unique electronic and steric properties enable it to interact with biological targets effectively.
  • Research and Development: Scientists are continually exploring the properties of 3-chloropyridine. For example, a recent study highlighted its effectiveness in synthesizing compounds that could improve drug delivery systems.
  • Environmental Impact: While 3-chloropyridine has useful applications, it is important to note that it is classified as a potentially harmful compound. Proper safety protocols should always be followed when handling this substance to mitigate any health risks.

As a compound with a blend of intriguing synthetic versatility and potential biological importance, 3-chloropyridine stands out as a focal point for both research and industrial applications. Its unique properties and reactivity continue to provide insight into the exciting world of organic chemistry.

Synonyms
3-CHLOROPYRIDINE
Pyridine, 3-chloro-
m-Chloropyridine
3-chloro pyridine
3-pyridinyl chloride
CCRIS 1715
EINECS 210-955-7
UNII-1M13HUC1P4
NSC 60200
BRN 0105744
1M13HUC1P4
.beta.-Chloropyridine
DTXSID3052309
NSC-60200
CHLOROPYRIDINE, 3-
DTXCID4030881
HSDB 8485
5-20-05-00406 (Beilstein Handbook Reference)
mChloropyridine
beta-Chloropyridine
Pyridine, 3chloro
210-955-7
inchi=1/c5h4cln/c6-5-2-1-3-7-4-5/h1-4
pwrbczzqrrpxab-uhfffaoysa-n
626-60-8
MFCD00006375
CHEMBL5414002
3-chloro-pyridine
3-chloranylpyridine
NSC60200
WLN: T6NJ CG
SCHEMBL73681
6266-00-8
Tox21_303995
BDBM50622786
AKOS015850486
CS-W011253
PS-9239
NCGC00357215-01
3-Chloropyridine, ReagentPlus(R), 99%
AC-15568
CAS-626-60-8
DB-023667
NS00035121
EN300-80717
P19758
3-Chloropyridine, Vetec(TM) reagent grade, 98%
A833911
Q223069
F0001-4054