Naldemedine | Solubility of Things

Identification

Molecular formula

C₃₂H₃₇NO₂

CAS number

916072-89-4

IUPAC name

3-(cyclopropylmethyl)-4a-hydroxy-9-methoxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

State

Naldemedine is solid at room temperature.

Melting point (Celsius)

189.00

Melting point (Kelvin)

462.15

Boiling point (Celsius)

312.50

Boiling point (Kelvin)

585.65

General information

Molecular weight

490.56g/mol

Molar mass

490.5610g/mol

Density

1.3600g/cm³

Appearence

Naldemedine is a white to off-white powder.

Comment on solubility

Solubility of 3-(cyclopropylmethyl)-4a-hydroxy-9-methoxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

The solubility characteristics of the compound, denoted by the chemical formula C₃₂H₃₇NO₂, present a fascinating case for study. Understanding its solubility can provide valuable insights into its potential applications in various fields, particularly in medicinal chemistry.

Key Aspects of Solubility

Solvent Polarity: The solubility of this compound can vary significantly depending on the polarity of the solvent used. Generally, compounds with large hydrophobic groups, such as cyclopropylmethyl groups in this structure, tend to be less soluble in polar solvents.
Temperature Dependence: Solubility often increases with temperature. Observing solubility behavior at different temperatures can indicate how the compound might perform under various conditions.
pH Effects: As with many organic compounds, the pH of the solution can affect solubility, particularly if the compound can either donate or accept protons under certain conditions.
Crystallinity: The crystalline structure of the compound can influence solubility as well; amorphous forms generally dissolve more easily compared to their crystalline counterparts.

When exploring the solubility of 3-(cyclopropylmethyl)-4a-hydroxy-9-methoxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, it is essential to conduct empirical measurements in various solvents to ascertain its behavior. Understanding these solubility dynamics is **crucial** for determining the compound's viability for applications within pharmaceuticals or material sciences.

Interesting facts

Interesting Facts about 3-(Cyclopropylmethyl)-4a-hydroxy-9-methoxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

This fascinating compound belongs to a class of organic molecules that showcases the remarkable diversity of isoquinoline derivatives. Here are some captivating insights:

Complex Structure: The compound features a unique multi-ring structure, indicative of the complexity often found in natural products and pharmaceutical agents.
Potential Biological Activity: Compounds like this one have been studied for their pharmacological properties, with promising activity in areas such as analgesics and anti-inflammatory agents.
Cyclopropyl Group: The presence of the cyclopropylmethyl group enhances the chemical stability and may provide interesting interactions in biological systems. As chemists often say, "Small changes can lead to significant effects!"
Hydroxy and Methoxy Groups: The hydroxyl and methoxy functional groups are essential contributors to the compound's reactivity and potential therapeutic effects, playing a critical role in hydrogen bonding and lipophilicity.
Research Implications: This compound presents an exciting avenue for further research, particularly in the synthesis of new drugs. Researchers are continually exploring its potential to lead to innovative treatments.

Overall, the multifaceted characteristics of 3-(cyclopropylmethyl)-4a-hydroxy-9-methoxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one demonstrate the dynamism and intrigue that chemical compounds offer in the fields of organic chemistry and pharmacology. Its complex structure and potential benefits make it a noteworthy subject for further exploration.

Synonyms

Methoxynaltrexone,3

SCHEMBL13172000

PDSP1_000439

PDSP2_000437