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Metformin

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Identification
Molecular formula
C4H11N5
CAS number
657-24-9
IUPAC name
3-(diaminomethylene)-1,1-dimethyl-guanidine
State
State

At room temperature, Metformin is solid.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
129.17g/mol
Molar mass
129.1650g/mol
Density
1.3140g/cm3
Appearence

Metformin hydrochloride appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-(diaminomethylene)-1,1-dimethyl-guanidine

The solubility of 3-(diaminomethylene)-1,1-dimethyl-guanidine (C4H11N5) presents interesting characteristics based on its chemical structure. This compound contains several functional groups that influence its interaction with solvents:

  • Polarity: The presence of amino groups contributes to its polar nature, making it more soluble in polar solvents such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds enhances solubility, particularly in protic solvents which can stabilize ions or polar solutes.
  • Chain Structure: The dimethyl groups add steric bulk, potentially influencing its solubility compared to similar compounds without such branches.

As a general rule, compounds with more polar functional groups tend to have higher solubility in water. In the case of 3-(diaminomethylene)-1,1-dimethyl-guanidine, its solubility is expected to be significant in aqueous environments, reflecting its biological relevance and application potential. Overall, the solubility behavior can be summarized as:

  1. High solubility in polar solvents.
  2. Moderate solubility in less polar organic solvents.
  3. Limited solubility in non-polar solvents.

In conclusion, the solubility of this compound is characterized by its polar interactions and hydrogen bonding capabilities, making it a compound of interest in both chemical and biological contexts.

Interesting facts

Interesting Facts about 3-(Diaminomethylene)-1,1-dimethyl-guanidine

3-(Diaminomethylene)-1,1-dimethyl-guanidine, commonly referred to as DMG, is quite a fascinating compound known for its unique structural features and versatile applications. Here are some intriguing aspects worth noting:

  • Biological Significance: DMG has been studied for its potential role in various biological processes. It’s a precursor in the synthesis of arginine, which is crucial for protein synthesis in organisms.
  • Pharmaceutical Interest: Due to its structural similarity to certain biological molecules, DMG shows promise in the pharmaceutical sector, particularly for its potential effects on nitric oxide synthesis and overall vascular health.
  • Chemical Reactions: This compound is known to participate in a variety of chemical reactions, including those essential in organic synthesis, which can result in the formation of different derivatives.
  • Research Applications: Its application in research, especially in studying metabolic pathways and biochemical interactions, provides valuable insights into cellular processes.
  • Analytical Chemistry: DMG is often employed as a reagent in various analytical techniques to detect and quantify different components due to its reactivity and ability to form complex compounds.

As a student or researcher, understanding the multifaceted nature of DMG can open doors to further exploration in medicinal chemistry and biochemical research. The potential future applications and implications linked to this compound could enhance our understanding of health and disease management.

In summary, the significance of 3-(diaminomethylene)-1,1-dimethyl-guanidine surpasses its basic chemical properties, establishing it as a noteworthy compound in both academic and practical contexts.

Synonyms
metformin
657-24-9
1,1-Dimethylbiguanide
N,N-dimethylimidodicarbonimidic diamide
Fluamine
Metformine
Metiguanide
Dimethylbiguanide
Imidodicarbonimidic diamide, N,N-dimethyl-
Flumamine
Gliguanid
Haurymelin
Melbin
N,N-Dimethylbiguanide
Metformina
Islotin
Dimethyldiguanide
N1,N1-Dimethylbiguanide
DMGG
NNDG
N,N-Dimethyldiguanide
Diabetosan
Metforminum
Glifage
Siofor
Metformine [INN-French]
Metforminum [INN-Latin]
3-(diaminomethylidene)-1,1-dimethylguanidine
LA-6023
BIGUANIDE, 1,1-DIMETHYL-
Dimethylbiguanid
1,1-Dimethyl biguanide
Metformin extended release
EINECS 211-517-8
CCRIS 9321
CHEBI:6801
DTXSID2023270
UNII-9100L32L2N
9100L32L2N
CHEMBL1431
DTXCID803270
Imidodicarbonimidic diamide-, N,N-dimethyl-
Metformina [DCIT]
Metformina [Spanish]
Metformine (INN-French)
Metforminum (INN-Latin)
Dimethylguanylguanidine
Metformin [USAN:INN:BAN]
C4H11N5
MLS000028493
[14C]metformin
[14C]-metformin
Metformin (USAN/INN)
NCGC00016564-01
SMR000058277
CAS-1115-70-4
N,N-dimethylguanylguanidine
Dianben
Obimet
N-dimethylbiguanide
MF8
Metforminum (Latin)
MFCD00242652
DMBG
Glucophage (Salt/Mix)
METFORMIN [INN]
n',n'-dimethylbiguanide
METFORMIN [MI]
METFORMIN [USAN]
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
METFORMIN [VANDF]
N,N-Dimethylguanylguanidin
METFORMIN [WHO-DD]
SCHEMBL8944
BSPBio_000007
BSPBio_002314
KBioGR_002310
KBioSS_002312
cid_14219
LA 6023 (Salt/Mix)
BIDD:GT0697
SPBio_001928
N(1),N(1)-dimethylbiguanide
BPBio1_000009
GTPL4503
GTPL4779
SCHEMBL9913821
SCHEMBL10276396
BDBM57047
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
A10BA02
cMAP_000016
HMS2089D19
HY-B0627
Tox21_302370
BBL012337
BDBM50229665
HSCI1_000295
NSC813213
s5958
STK011633
STL483693
STL484070
N,N-Dimethyltriimidodicarbonic diamide
AKOS000121065
AKOS005206848
AKOS015966566
CCG-102605
DB00331
NSC-813213
3-carbamimidoyl-1,1-dimethyl-guanidine
NCGC00016564-02
NCGC00016564-03
NCGC00016564-05
NCGC00016564-07
NCGC00188959-01
NCGC00255255-01
AC-32484
AS-65365
CAS-657-24-9
SBI-0206876.P001
1-carbamimidamido-N,N-dimethylmethanimidamide
CS-0009563
NS00000333
EN300-23696
C07151
D04966
D72476
EN300-746417
Q19484
(E)-3-[Amino(dimethylamino)methylidene]guanidine
1-[(E)-amino(dimethylamino)methylidene]guanidine
{[amino(dimethylamino)methylidene]amino}methanimidamide
BRD-K79602928-003-04-1
BRD-K79602928-003-08-2
BRD-K79602928-003-18-1
BRD-K79602928-003-19-9
3-(diaminomethylene)-1,1-dimethyl-guanidine;hydrochloride
[(E)-[AMINO(DIMETHYLAMINO)METHYLIDENE]AMINO]METHANIMIDAMIDE
3-[bis(azanyl)methylidene]-1,1-dimethyl-guanidine;hydrochloride
211-517-8