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Codeine phosphate

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Identification
Molecular formula
C18H21NO3 · H3PO4
CAS number
52-28-8
IUPAC name
[3-(diethylamino)-2,2-dimethyl-propyl] 3-hydroxy-2-phenyl-propanoate;phosphoric acid
State
State

At room temperature, codeine phosphate is a solid. It is typically supplied in powder form for pharmaceutical use.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
338.00
Boiling point (Kelvin)
611.15
General information
Molecular weight
431.36g/mol
Molar mass
431.3640g/mol
Density
1.3000g/cm3
Appearence

Codeine phosphate typically appears as a white crystalline powder. It is odorless and has a bitter taste. The crystals can sometimes be fine and needle-like.

Comment on solubility

Solubility of [3-(diethylamino)-2,2-dimethyl-propyl] 3-hydroxy-2-phenyl-propanoate; phosphoric acid

The solubility of this compound, a complex organic structure, can be influenced by various factors. Its solubility is primarily determined by:

  • Polarity: The presence of polar functional groups, such as the hydroxy and phosphoric acid parts, increases the likelihood of solubility in polar solvents, particularly water.
  • Hydrogen bonding: The ability of the hydroxy group to participate in hydrogen bonding enhances solubility in aqueous solutions, making it more soluble in water than many non-polar organic compounds.
  • Chain length: The diethylamino group introduces a significant hydrophobic character. This balance between hydrophilicity and hydrophobicity dictates the solubility behavior in various solvents.
  • Temperature: Generally, increasing temperature can increase the solubility of organic compounds in solvents, so higher temperatures may improve solubility for this compound.

In summary, while [3-(diethylamino)-2,2-dimethyl-propyl] 3-hydroxy-2-phenyl-propanoate; phosphoric acid exhibits good solubility in aqueous environments due to its polar characteristics and ability to form hydrogen bonds, its overall solubility profile may vary significantly depending on the solvent used and environmental conditions.

Interesting facts

Exploring [3-(diethylamino)-2,2-dimethyl-propyl] 3-hydroxy-2-phenyl-propanoate; phosphoric acid

This intriguing compound is a fascinating example of the complex interplay between organic chemistry and pharmaceuticals. As a member of the class of esters, it possesses notable properties that can significantly impact biochemical processes.

Key Characteristics

  • Structural Diversity: The compound features a unique combination of a bulky alkyl group and an amino moiety, making it a prime candidate for research into structure-activity relationships.
  • Biological Relevance: Compounds like this are often explored for their potential medicinal properties, particularly in drug design and development.
  • Interaction with Phosphoric Acid: The presence of phosphoric acid can enhance the solubility and bioavailability of the compound, which is critical for its effectiveness in biological systems.

Interesting Applications

This compound is not merely a laboratory curiosity; its potential applications can stretch across various fields:

  • Pharmaceuticals: It may be evaluated for efficacy in treating conditions influenced by neural pathways, given its amino group.
  • Agricultural Chemistry: Compounds with similar structures have been studied for use in herbicides and pesticides, contributing to agricultural advancements.
  • Analytical Chemistry: Its unique properties make it a suitable candidate for studies in periodical and chromatographic analysis.

Conclusion

Overall, [3-(diethylamino)-2,2-dimethyl-propyl] 3-hydroxy-2-phenyl-propanoate; phosphoric acid exemplifies the rich complexity of organic compounds. The investigation of such compounds not only enhances our understanding of organic chemistry but also paves the way for innovative solutions in health and industry.

Synonyms
AMPROTROPINE PHOSPHATE
Syntropan
134-53-2
6831EK981Y
AP 407
UNII-6831EK981Y
3-Diethylamino-2,2-dimethylpropyl tropate phospate
1-Propanol, 3-(diethylamino)-2,2-dimethyl-, tropate, phosphate
d,l-Tropasaeureester des 3-diaethylamino-2,2-dimethyl-1-propanol phosphat [German]
SCHEMBL250070
CHEMBL4297085
DTXSID50928381
AMPROTROPINE PHOSPHATE [MI]
d,l-Tropasaeureester des 3-diaethylamino-2,2-dimethyl-1-propanol phosphat
Tropic acid, 3-(diethylamino)-2,2-dimethylpropyl ester, phosphate (1:1)
Q27264201
[3-(diethylamino)-2,2-dimethylpropyl] 3-hydroxy-2-phenylpropanoate;phosphoric acid
Phosphoric acid--3-(diethylamino)-2,2-dimethylpropyl 3-hydroxy-2-phenylpropanoate (1/1)