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Lidocaine

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Identification
Molecular formula
C14H22N2O
CAS number
137-58-6
IUPAC name
[3-(diethylamino)-2,2-dimethyl-propyl] 4-aminobenzoate
State
State

At room temperature, lidocaine is in a solid state.

Melting point (Celsius)
66.00
Melting point (Kelvin)
339.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
234.34g/mol
Molar mass
234.3370g/mol
Density
1.0260g/cm3
Appearence

Lidocaine usually appears as a white crystalline powder. It is odorless and has a slightly bitter taste. In some formulations, it may appear as a colorless crystalline solid.

Comment on solubility

Solubility of [3-(diethylamino)-2,2-dimethyl-propyl] 4-aminobenzoate

The solubility of [3-(diethylamino)-2,2-dimethyl-propyl] 4-aminobenzoate presents interesting characteristics due to its unique molecular structure and functional groups. Understanding its solubility can be approached from several perspectives:

  • Polarity: The presence of the diethylamino group enhances the compound's ability to interact with polar solvents, increasing its solubility in aqueous solutions.
  • Hydrophobic Regions: Conversely, the dimethyl and aromatic components may introduce hydrophobic characteristics, potentially limiting solubility in water but enhancing it in organic solvents.
  • pH Dependence: The solubility may also vary with changes in pH; being a salt, it is more soluble in acidic or basic conditions where it can exist as a positively or negatively charged species, thus improving interaction with water molecules.

Overall, it is commonly observed that:

  1. The compound is likely soluble in organic solvents such as ethanol and acetone.
  2. It may have limited solubility in pure water, but this can be significantly improved by adjusting pH levels.

As with many compounds, temperature can also play a critical role in solubility, with increased temperatures generally leading to higher solubility in most cases. Understanding these aspects is crucial for applications in biological systems and chemical formulations.

Interesting facts

Interesting Facts about [3-(diethylamino)-2,2-dimethyl-propyl] 4-aminobenzoate

[3-(diethylamino)-2,2-dimethyl-propyl] 4-aminobenzoate is a fascinating compound that showcases the ingenuity of organic chemistry. This compound is known for its role in various fields, especially in pharmaceuticals and material science.

Key Highlights:

  • Psychoactive Potential: Some analogs of this compound exhibit psychoactive effects, making it of interest in the study of neurotransmission and potential therapeutic applications.
  • Amine Functionality: The presence of a diethylamino group in its structure infers interesting properties, such as enhanced solubility and reactivity, which may facilitate interactions with biological systems.
  • Versatile Applications: Compounds like these are often investigated for use in drug formulation and delivery systems, showcasing their versatile applications in healthcare and beyond.
  • Structure-Activity Relationship (SAR): Researchers often examine the variations in structure to understand how modifications affect the activity of the compound, leading to the development of more effective pharmaceuticals.
  • Analytical Chemistry: Techniques such as NMR and HPLC are commonly used to analyze this compound, providing students and researchers with practical insights into separation and identification methods.

In summary, [3-(diethylamino)-2,2-dimethyl-propyl] 4-aminobenzoate embodies a blend of structural complexity and functional diversity, making it a rich subject for study in both academic and practical contexts. Its relevance in modern science reflects the ongoing search for innovative solutions in medicine and technology.

Synonyms
Dimethocaine
94-15-5
Larocaine
3-(Diethylamino)-2,2-dimethylpropyl 4-aminobenzoate
UNII-R3L4A6GOWZ
R3L4A6GOWZ
NSC 68927
BRN 2215967
1-Propanol, 3-(diethylamino)-2,2-dimethyl-, p-aminobenzoate
DIMETHOCAINE [MI]
NSC-68927
(3-Diethylamino-2,2-dimethyl)propyl 4-aminobenzoat
1-Propanol, 3-(diethylamino)-2,2-dimethyl-, 4-aminobenzoate (ester)
1-Propanol, 3-(diethylamino)-2,2-dimethyl-, p-aminobenzoate (ester)
DIMETHOCAINE [WHO-DD]
[3-(diethylamino)-2,2-dimethylpropyl] 4-aminobenzoate
4-Aminobenzoesaeure-3-diethylamino-2,2-dimethylproplylester
DTXSID40240185
3-Diethylamino-2,2-dimethylpropyl 4-Aminobenzoate
NSC68927
3-(Dimethylamino)-2,2-dimethyl-1-propanol p-aminobenzoate
2-Dicyclohexylphosphino-2',6'-bis(N,N-dimethylamino)biphenyl; 2'-(Dicyclohexylphosphino)-N2,N2,N6,N6-tetramethylbiphenyl-2,6-diamine
SCHEMBL25088
CHEMBL4752832
DTXCID40162676
CHEBI:135154
BCP21170
1-Propanol, 2-[(diethylamino)methyl]-2-methyl-, 1-(4-aminobenzoate)
AKOS022180477
WLN: ZR DVO1X1&1&1N2&2
1-Propanol,2-dimethyl-, p-aminobenzoate
DS-16345
FD178421
DB-347662
HY-121870
CS-0083580
D4179
NS00005054
F12666
1-Propanol,2-dimethyl-, 4-aminobenzoate (ester)
1-Propanol,2-dimethyl-, p-aminobenzoate (ester)
A844843
Q3827109
3-(Diethylamino)-2,2-dimethylpropyl 4-aminobenzoate #
4-Aminobenzoic Acid 3-Diethylamino-2,2-dimethylpropyl Ester
1-Propanol, 3-(diethylamino)-2,2-dimethyl-, 4-aminobenzoate (ester) (9CI)
1-Propanol, 3-(diethylamino)-2,2-dimethyl-, p-aminobenzoate (ester) (8CI)