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Fentanyl

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Identification
Molecular formula
C22H28FN3O
CAS number
437-38-7
IUPAC name
3-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide
State
State

At room temperature, Fentanyl is typically a solid. It is often encountered as a powder but can also be found in transdermal patches and other pharmaceutical formulations.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
577.06
Boiling point (Kelvin)
850.21
General information
Molecular weight
336.47g/mol
Molar mass
336.4690g/mol
Density
1.2260g/cm3
Appearence

Fentanyl is a white to off-white solid substance that is usually found as a crystalline powder. It may also appear in a slightly yellow or tan form depending on purity and specific formulation. In medical settings, it is often dissolved in a liquid for injection.

Comment on solubility

Solubility of 3-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide

The solubility of 3-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide can be influenced by several factors, including its molecular structure and polarity. Here are some notable aspects:

  • Polarity: The presence of a diethylamino group contributes to the overall basicity of the compound, which can enhance solubility in polar solvents like water.
  • Hydrophobic regions: The ethyl groups and the fluorophenyl moiety introduce hydrophobic characteristics, potentially reducing solubility in polar solvents.
  • Compatibility with organic solvents: This compound is likely more soluble in organic solvents such as ethanol, methanol, or chloroform due to its carbon-rich structure.
  • Temperature dependence: Solubility may increase with temperature, which is common for many organic compounds.

To conclude, the solubility of 3-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide is characterized by a balance between its polar and non-polar characteristics. It is crucial to conduct specific solubility tests in order to determine its behavior in various solvents for practical applications.

Interesting facts

Interesting Facts about 3-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide

This compound, a member of the amide class, presents itself as a fascinating subject in medicinal chemistry and pharmacology. With its unique structure, it highlights several important features:

  • Amide Functionality: Amides are notable for their role in protein synthesis and as intermediates in organic synthesis. They are characterized by a carbonyl group followed by a nitrogen atom, which significantly influences their reactivity.
  • Fluoro-substitution: The presence of fluorine, especially in a para position, often enhances the biological activity of compounds. Fluorine can improve metabolic stability, lipophilicity, and binding affinity to biological targets, making it a valuable element in drug design.
  • Diethylamino Group: The diethylamino moiety contributes basicity to the compound. This feature can facilitate interactions with receptor sites, playing a crucial role in its potential pharmacological effects.
  • Analgesic Effects: Compounds like this one are often explored in the context of analgesic (pain-relieving) medications. The structural elements may correlate with enhancing pain relief while minimizing side effects.
  • Research Potential: The exploration of similar compounds has led to advancements in therapeutic agents for various conditions, including but not limited to, anxiety, depression, and neurodegenerative disorders. The intricate balance of its functional groups invites further research into its mechanisms of action.

As we continue to investigate and unlock the potential of such compounds, it becomes evident that structure influences function. This compound is a perfect example of how subtle changes at the molecular level can lead to significant differences in pharmacodynamics and pharmacokinetics.

In summary, 3-(diethylamino)-N-(5-ethyl-2-fluoro-phenyl)butanamide stands as an intriguing entity in the realm of chemical research, prompting both scientific inquiry and potential medicinal applications.

Synonyms
3-(Diethylamino)-5'-ethyl-2'-fluorobutyranilide
965-27-5
BRN 2698823
beta-Diaethylamino-3-aethyl-6-fluor-butyranilid [German]
Butanamide, 3-(diethylamino)-N-(5-ethyl-2-fluorophenyl)-
BUTYRANILIDE, 3-(DIETHYLAMINO)-5'-ETHYL-2'-FLUORO-
beta-Diaethylamino-3-aethyl-6-fluor-butyranilid
DTXSID90914485
3-(Diethylamino)-N-(5-ethyl-2-fluorophenyl)butanimidic acid