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Galantamine hydrobromide

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Identification
Molecular formula
C22H26N2O4
CAS number
1953-04-4
IUPAC name
[3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] acetate
State
State

At room temperature, [3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] acetate is in a solid state. It is usually provided as a crystalline powder.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
155.00
Boiling point (Kelvin)
428.15
General information
Molecular weight
368.46g/mol
Molar mass
368.4280g/mol
Density
1.3648g/cm3
Appearence

In its pure form, this compound is typically a white to off-white crystalline powder. It may exhibit a faint odour and is often encountered in a solid state suitable for laboratory handling.

Comment on solubility

Solubility of the Compound

The solubility of the compound [3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] acetate (C22H26N2O4) is influenced by several factors due to its complex structure. Understanding its solubility is crucial for its applications in various chemical formulations, medicinal chemistry, and pharmacology.

Key Points on Solubility:

  • Polar and Nonpolar Characteristics: The compound contains both polar (such as the carbamoyl and acetate groups) and nonpolar (the hexahydro and methoxy groups) regions, suggesting that it may exhibit variable solubility in different solvents.
  • Solvent Compatibility: Expect higher solubility in polar solvents like methanol and ethanol, while its nonpolar portions may enhance solubility in organic solvents such as chloroform and ethyl acetate.
  • Effect of Temperature: Like many organic compounds, the solubility may increase with temperature; thus, heating solvents may improve dissolution rates.

In summary, while the solubility of this compound can vary significantly based on the choice of solvent and conditions, its blend of polar and nonpolar components provides an interesting array of solubility characteristics that are valuable for further research and development in chemical sciences.

Interesting facts

Interesting Facts about 3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl acetate

This compound, a member of the benzoquinolizidine family, exhibits a fascinating chemical architecture that intrigues chemists and pharmacologists alike. Here are some compelling aspects worth noting:

  • Structural Complexity: The molecule showcases a unique structure that includes a hexahydro-1H-benzo[a]quinolizin moiety. This complexity suggests potential for intriguing interactions and biological activity.
  • Functional Groups: The presence of diethylcarbamoyl and methoxy groups within its structure highlights the compound's potential for varied reactivity and functionality in organic synthesis.
  • Pharmacological Potential: Compounds like this often exhibit significant biological activity, which can lead to applications in medicinal chemistry. Their unique frameworks make them targets for the development of novel pharmaceuticals.
  • Research Applications: Due to its structural features, this compound can serve as a valuable lead in drug discovery processes. The exploration of its derivatives might unveil new therapeutic agents.
  • Interdisciplinary Interest: The chemical properties and possible bioactivity of this compound also position it at the intersection of chemistry, biology, and material science, fostering collaboration across various scientific disciplines.

As a noteworthy candidate for further study, 3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl acetate reminds us of the intricate relationships between structure and function in the realm of chemical compounds. Its potential to impact various fields from drug development to basic research highlights the importance of ongoing exploration in chemistry.

Synonyms
benzquinamide
Promecon
Emete-con
63-12-7
Benzquinamid
Benzochinamide
Benzoquinamide
Emeticon
Benzquinamidum
Quantryl
Benzchinamide
Benzchinamidum
benzquinamida
Benzoquinamida
Quantril
Benzchinamid
Benzquinamidum [INN-Latin]
Benzoquinamida [INN-Spanish]
P-2647
Benzquinamide [USAN:INN:BAN]
Benzquinamide (USAN)
P 2647
HSDB 3295
[3-(diethylcarbamoyl)-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl] acetate
NSC-64375
DTXSID9022657
CHEBI:27662
P2647
2-Hydroxy-3-diethylcarbamyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzoquinolizine acetate
2H-Benzo(a)quinolizine-3-carboxamide, N,N-diethyl-1,3,4,6,7,11b-hexahydro-2-hydroxy-9,10-dimethoxy-, acetate (ester)
NSC-108159
NSC-169193
P2647;BZQ; Benzoquinamide
2-Acetoxy-3-(N,N-diethylcarboxamido)-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzopyridocoline
2-Acetoxy-3-diethylcarbamyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11b-benzo(a)quinolizine
3-Diethylcarbamoyl-2,3,4,6,7,11b-hexahydro-9,10-dimethoxy-1H-benzo(a)chinolizin-2-yl acetat
DTXCID702657
2-(Acetyloxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo(a)quinolizine-3-carboxamide
N,N-Diethyl-1,3,4,6,7,11b-hexahydro-2-hydroxy-9,10-dimethoxy-2H-benzo(a)quinolizine-3-carboxamide acetate (ester)
NSC64375
N,N-Diethyl-1,3,4,6,7,11b-hexahydro-2-hydroxy-9,10-dimethoxy-2H-benzo(a)quinolizine-3-carboxamide acetate
23844-24-8
Benzquinamidum (INN-Latin)
BENZQUINAMIDE [USAN]
2-(acetoxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizine-3-carboxamide
2-(acetyloxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizine-3-carboxamide
2H-Benzo[a]quinolizine-3-carboxamide, 2-(acetyloxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-
3-(diethylcarbamoyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl acetate
Benzoquinamida (INN-Spanish)
Emite-con
2-(Acetoxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-diemethoxy-2H-benzo[a]quinolizine-3-carboxamide
2H-Benzo(a)quinolizine-3-carboxamide, 2-(acetyloxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-
3-(diethylcarbamoyl)-9,10-dimethoxy-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-yl acetate
N,N-Diethyl-1,3,4,6,7,11b-hexahydro-2-hydroxy-9,10-dimethoxy-2H-benzo[a]quinolizine-3-carboxamide acetate (ester)
BENZQUINAMIDE [MI]
BENZQUINAMIDE [INN]
BENZQUINAMIDE [HSDB]
BENZQUINAMIDE [VANDF]
BENZQUINAMIDE [WHO-DD]
2-(Acetoxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-diemethoxy-2H-benzo(a)quinolizine-3-carboxamide
2-(acetoxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo(a)quinolizine-3-carboxamide
2H-Benzo[a]quinolizine-3-carboxamide,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-, (2.alpha.,3.beta.,11b.alpha.)-
2H-Benzo[a]quinolizine-3-carboxamide,N-diethyl-1,3.alpha.,4,6,7,11b.beta.-hexahydro-2.beta.-hydroxy-9,10-dimethoxy-, acetate (ester)
3-(diethylcarbamoyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl acetate
3-(diethylcarbamoyl)-9,10-dimethoxy-1H,2H,3H,4H,6H,7H,11bH-pyrido(2,1-a)isoquinolin-2-yl acetate
SCHEMBL49405
GTPL7124
CHEMBL1201250
Tox21_113977
HY-U00244
NSC108159
NSC169193
AKOS037643551
CS-7421
DB00767
CAS-63-12-7
NCGC00274274-01
3-[(diethylamino)carbonyl]-9,10-bis(methyloxy)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl acetate
AS-16851
DA-51031
NS00001225
D00243
L000844
Q4890814
3-[(Diethylamino)carbonyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl acetate
3-[(Diethylamino)carbonyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl acetate #
N,N-DIETHYL-1,3,4,6,7,11B-HEXAHYDRO-2-HYDROXY-9,10-DIME THOXY-2H-BENZO(A)QUINOLIZINE-3-CARBOXAMIDE ACETATE