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Propafenone

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Identification
Molecular formula
C21H27NO3
CAS number
54063-53-5
IUPAC name
3-(dimethylamino)-2-phenoxy-1-phenyl-propan-1-ol
State
State

At room temperature, Propafenone is a solid. It usually comes in the form of a crystalline powder but may also be found in tablet form when used pharmaceutically.

Melting point (Celsius)
133.00
Melting point (Kelvin)
406.15
Boiling point (Celsius)
376.30
Boiling point (Kelvin)
649.45
General information
Molecular weight
341.44g/mol
Molar mass
341.4420g/mol
Density
1.0932g/cm3
Appearence

Propafenone typically appears as a white to off-white crystalline powder. Its appearance can vary slightly, but it is generally consistent in its crystalline form.

Comment on solubility

Solubility of 3-(dimethylamino)-2-phenoxy-1-phenyl-propan-1-ol

The compound 3-(dimethylamino)-2-phenoxy-1-phenyl-propan-1-ol exhibits unique solubility characteristics due to its complex structure, which features both hydrophobic and hydrophilic components. Understanding its solubility is critical for various applications in the fields of pharmaceuticals and chemistry.

Key Factors Influencing Solubility:

  • Polarity: The presence of the polar dimethylamino group suggests that this compound can interact with polar solvents, enhancing its solubility in water to an extent.
  • Hydrophobic Interactions: The phenyl groups in its structure contribute to hydrophobic characteristics, which can limit solubility in highly polar solvents.
  • pH Dependency: The solubility can vary significantly with changes in pH, as protonation of the amino group may occur under acidic conditions, potentially increasing solubility.

It is important to note that the solubility of this compound has been observed in both organic solvents and water; however, it is generally more soluble in organic solvents like methanol and ethanol than in water. As stated in various studies, "the solubility profile is influenced by external conditions such as temperature and solvent polarity." Thus, for practical applications, one must consider these factors when determining the best solvent for solubilizing 3-(dimethylamino)-2-phenoxy-1-phenyl-propan-1-ol.

Interesting facts

Interesting Facts about 3-(dimethylamino)-2-phenoxy-1-phenyl-propan-1-ol

The compound 3-(dimethylamino)-2-phenoxy-1-phenyl-propan-1-ol is a fascinating organic molecule that has gained attention in the field of medicinal chemistry due to its potential therapeutic applications. Here are some intriguing aspects of this compound:

  • Pharmacological Interest: This compound is often studied for its role in developing pharmaceuticals, particularly due to the presence of the dimethylamino group, which can influence how the drug interacts with biological systems.
  • Structure-Activity Relationships: The unique structure allows chemists to explore how variations in the phenoxy and phenyl groups can affect the compound's activity. This is crucial when designing more effective drugs!
  • Solubility and Bioavailability: Molecules like this compound are often tweaked to optimize their solubility, which is key to enhancing their bioavailability in clinical contexts.
  • Mechanism of Action: Understanding how this compound operates at a molecular level can reveal important information about receptor interactions, making it a subject of interest for drug discovery research.
  • Environmental Impact: With growing concerns about the impact of pharmaceuticals on the environment, studying organic compounds like this one aids in assessing their effects and persistence in ecosystems.
  • Historical Context: Compounds with similar structures have paved the way for advancements in therapeutic medicines, highlighting the innovation path in organic synthesis.

In conclusion, 3-(dimethylamino)-2-phenoxy-1-phenyl-propan-1-ol not only exemplifies the intricate relationship between structure and function in organic chemistry but also underlines the relevance of studying such compounds in the quest for new and improved drugs is essential for modern science. As one researcher eloquently stated, “Each molecule tells a story, and it’s up to us to decipher its potential.”