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3-Ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one

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Identification
Molecular formula
C16H24N2O2
CAS number
40001-78-9
IUPAC name
3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one
State
State

At room temperature, 3-Ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one is typically found as a solid. The compound is stable under standard conditions but may require specific storage to maintain its integrity.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
274.37g/mol
Molar mass
274.3660g/mol
Density
1.2057g/cm3
Appearence

The compound typically appears as a crystalline solid. The crystalline form may vary in color from white to off-white, depending on the purity and specific structural characteristics.

Comment on solubility

Solubility of 3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one

The solubility of 3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one, a complex organic compound, is influenced by several factors, including its molecular structure and hydrophobic/hydrophilic balance. Here are some key points to consider:

  • Structural Characteristics: The presence of the morpholinomethyl group enhances the compound's ability to solvate in polar solvents due to its nitrogen atoms, which can participate in hydrogen bonding.
  • Solvent Interaction: This compound is expected to exhibit higher solubility in:
    • Polar solvents such as water and alcohols due to its functional groups.
    • Non-polar solvents may have a lower solubility given the hydrophobic nature of certain alkyl groups present.
  • Temperature Influence: As a general rule, increasing the temperature can lead to better solubility for solid compounds. Thus, this compound may dissolve more readily at elevated temperatures.
  • pH Sensitivity: The solubility may also vary with changes in pH, particularly if the compound can exist in protonated or deprotonated forms affecting solubility dynamics.

In conclusion, understanding the solubility of this compound requires a multifaceted approach, taking into account its unique chemical features and interactions with various solvents. As is often quoted in the field, "The right solvent can make all the difference in the world."

Interesting facts

Interesting Facts about 3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one

3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one is a fascinating compound that falls within the realm of indole derivatives, which are known for their diverse biological activities. Here are some noteworthy points about this compound:

  • Pharmacological Potential: This compound has attracted attention for its potential therapeutic applications, particularly in the field of neuroscience and pharmaceuticals.
  • Structural Diversity: The structure of this compound includes a morpholinomethyl group, which can enhance its solubility and bioavailability, making it a subject of interest for drug development.
  • Indole Framework: The indole moiety is common in nature and serves as a backbone for many biologically active compounds, highlighting the significance of this class of molecules in medicinal chemistry.
  • Derivatives Exploration: The unique combination of ethyl and methyl groups allows for the exploration of structure-activity relationships (SAR), which is crucial in optimizing the compound's efficacy.
  • Research Interest: Studies have indicated that compounds with tetrahydroindole structures are often investigated for their effects on neurotransmitter systems, which could lead to advancements in treating mood disorders.
  • Historical Context: The indole derivatives have a rich history in medicinal chemistry; for instance, many classic drugs such as tryptophan derived compounds have roots in this framework.

In summary, 3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one is a compound that exemplifies the intricate relationship between chemical structure and biological activity, making it a pivotal topic for ongoing research and optimization in drug discovery.

Synonyms
MOLINDONE
(+-)-Molindone
Molindona
Molindonum
Molindonum [INN-Latin]
Molindona [INN-Spanish]
HSDB 3131
UNII-RT3Y3QMF8N
RT3Y3QMF8N
3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
SPN-810
EN-1733A
Indol-4(5H)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one
DTXSID9023332
4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-
Molindonum (INN-Latin)
Molindona (INN-Spanish)
indol-4(5h)-one
DTXCID603332
N05AE02
7416-34-4
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
(+/-)-Molindone
Molindone (INN)
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-4-one
CHEMBL460
CHEBI:6965
MOLINDONE [INN]
Molindone [INN:BAN]
3ss-Acetoxycholesta-5,7-diene; 7,8-Didehydrocholesteryl acetate; 7-Dehydrocholesterol acetate; 7-Dehydrocholesteryl acetate; Cholesta-5,7-dien-3ss-yl acetate; NSC 226869
MOLINDONE [MI]
MOLINDONE [HSDB]
Prestwick0_001035
Prestwick1_001035
Prestwick2_001035
Prestwick3_001035
MOLINDONE [VANDF]
MOLINDONE [WHO-DD]
Oprea1_038890
BSPBio_001249
GTPL207
SCHEMBL149233
SPBio_003100
BPBio1_001374
PXB80513
BDBM50130290
AKOS015899067
AC-7052
DB01618
SDCCGSBI-0633741.P001
3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one
NCGC00162218-01
NCGC00162218-02
NCGC00162218-03
NCGC00162218-11
DA-65591
TS-08153
HY-107434
AB00514709
CS-0028466
NS00010544
EN300-51101
C07230
D08226
AB00514709_07
L001248
Q593166
BRD-A65280694-003-03-8
BRD-A65280694-003-13-7
Z802671522
3-Ethyl-2-methyl-5-morpholin-4-ylmethyl-1,5,6,7-tetrahydro-indol-4-one
3-ethyl-2-methyl-5-[(morpholin-4-yl)methyl]-4,5,6,7-tetrahydro-1H-indol-4-one
3-Ethyl-2-methyl-5-morpholin-4-ylmethyl-1,5,6,7-tetrahydro-indol-4-one ( Molindone)
3-Ethyl-2-methyl-6-(4-morpholinylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one #