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Naproxen

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Identification
Molecular formula
C14H14O3
CAS number
22204-53-1
IUPAC name
3-ethyl-4-(4-methoxyphenyl)-2-methyl-cyclohex-3-ene-1-carboxylic acid
State
State

At room temperature, Naproxen is in the form of a crystalline solid. It is not usually found in gaseous or liquid states under standard conditions.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.00
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.00
General information
Molecular weight
230.26g/mol
Molar mass
230.2600g/mol
Density
1.1850g/cm3
Appearence

Naproxen appears as a white to off-white crystalline powder. It is practically odorless and has a bitter taste. The compound is known for its stability under normal conditions.

Comment on solubility

Solubility of 3-ethyl-4-(4-methoxyphenyl)-2-methyl-cyclohex-3-ene-1-carboxylic acid

The solubility of 3-ethyl-4-(4-methoxyphenyl)-2-methyl-cyclohex-3-ene-1-carboxylic acid in various solvents can be influenced by several factors, including its molecular structure and functional groups present. This compound features a carboxylic acid functional group, which generally tends to increase solubility in polar solvents due to the ability to form hydrogen bonds. Here are some key points regarding its solubility:

  • Polar Solvents: Compounds with carboxylic acid groups are typically soluble in polar solvents such as water and alcohols.
  • Non-Polar Solvents: Its solubility in non-polar solvents may be limited due to the hydrophilic nature of the carboxylic acid, making it less favorable for these solvents.
  • Temperature Effect: Solubility can be markedly affected by temperature; higher temperatures may enhance solubility in certain solvents.
  • pH Influence: In acidic conditions, the carboxylic acid may remain undissociated, while in basic conditions, it may ionize, affecting its solubility profile.

In conclusion, the solubility of 3-ethyl-4-(4-methoxyphenyl)-2-methyl-cyclohex-3-ene-1-carboxylic acid demonstrates the complex interplay of molecular structure and environmental conditions. As a general guideline, it is expected to have better solubility in polar solvents compared to non-polar ones, with variations depending on specific circumstances.

Interesting facts

Interesting Facts About 3-ethyl-4-(4-methoxyphenyl)-2-methyl-cyclohex-3-ene-1-carboxylic acid

This compound showcases a fascinating structure characteristic of organic chemistry. Here are some intriguing aspects that make it noteworthy:

  • Cyclic Nature: The compound contains a cyclohexene ring, which is a six-membered carbon ring that integrates unsaturation (double bonds). This structural feature can significantly affect its reactivity and stability.
  • Substituents: The presence of an ethyl group and a methoxyphenyl group adds complexity and functionality to the molecule, influencing its chemical properties and potential interactions with other substances.
  • Aromaticity: The methoxyphenyl group introduces aromatic stability, as substitution on aromatic rings often leads to unique electronic and chemical behaviors. This property is vital in pharmaceuticals where aromatic compounds are prevalent.
  • Applications in Synthesis: Such compounds are often utilized in organic synthesis pathways, potentially acting as intermediates in the development of new drugs or materials.
  • Bioactivity Potential: Many derivatives of cyclohexene structures are investigated for their bioactive properties, which may include anti-inflammatory or anticancer activities, making this compound of interest for medicinal chemistry research.

As noted by chemists, "The beauty of organic compounds lies not just in their structure but in the vast array of reactions they can undergo.” This compound serves as a perfect example of that beauty, merging intricate design with diversity in application.

In summary, 3-ethyl-4-(4-methoxyphenyl)-2-methyl-cyclohex-3-ene-1-carboxylic acid exemplifies the elegance of organic chemistry, with its complex structure and rich potential for varied applications.

Synonyms
1755-52-8
3-Ethyl-4-(4-methoxyphenyl)-2-methyl-3-cyclohexene-1-carboxylic acid
CARBESTROL
3-ethyl-4-(4-methoxyphenyl)-2-methylcyclohex-3-ene-1-carboxylic acid
NSC-19962
U 2911
3-Ethyl-4-(p-methoxyphenyl)-2-methyl-3-cyclohexene-1-carboxylic acid
MLS002638713
CHEBI:34610
3-Cyclohexene-1-carboxylic acid, 3-ethyl-4-(4-methoxyphenyl)-2-methyl-
3-Cyclohexene-1-carboxylic acid, 3-ethyl-4-(p-methoxyphenyl)-2-methyl-
NSC19962
6-Ethyl-4'-methoxy-5-methyl-2,3,4,5-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid
ORF 2166
UNII-C85AI8SOCH
BRN 2653888
C85AI8SOCH
2-Methyl-3-ethyl-4-p-methoxyphenyl-delta(sup 3)-cyclohexene carboxylic acid
4-10-00-01138 (Beilstein Handbook Reference)
SCHEMBL9417514
CHEMBL1893014
DTXSID70938669
HMS3086P03
NSC 19962
SMR001548183
WLN: L6UTJ AR DO1& B2 C1 DVQ
SR-01000880711
SR-01000880711-2
Q27116178
3-ethyl-4-p-methoxyphenyl-2-methyl-3-cyclohexene-1-carboxylic acid
6-Ethyl-4'-methoxy-5-methyl-2,3,4,5-tetrahydro[1,1'-biphenyl]-4-carboxylato