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3-Fluoro-4-methylaniline

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Identification
Molecular formula
C7H8FN
CAS number
452-77-3
IUPAC name
3-fluoro-4-methyl-aniline
State
State

At room temperature, 3-Fluoro-4-methylaniline is typically a liquid, considering its melting point and boiling point. It is usually handled in sealed containers to prevent exposure to moisture or air.

Melting point (Celsius)
-18.00
Melting point (Kelvin)
255.15
Boiling point (Celsius)
205.00
Boiling point (Kelvin)
478.15
General information
Molecular weight
125.15g/mol
Molar mass
125.1550g/mol
Density
1.1020g/cm3
Appearence

3-Fluoro-4-methylaniline is a colorless oily liquid. It is often used as an intermediate in chemical synthesis and might have a slight aromatic amine odor.

Comment on solubility

Solubility of 3-fluoro-4-methyl-aniline

3-fluoro-4-methyl-aniline, with the chemical formula C7H8FN, exhibits some interesting characteristics regarding its solubility:

  • Polarity: The presence of the fluorine substituent introduces polarity, which can enhance solubility in polar solvents.
  • Aromatic Structure: The aromatic ring structure provides some degree of lipophilicity, which may limit its solubility in non-polar solvents.
  • Temperature Dependence: The solubility of this compound can increase with temperature, making it more soluble in hot solvents.
  • Common Solvents: It is likely to be soluble in organic solvents such as ethanol and methanol, while having limited solubility in water due to its hydrophobic aromatic component.

In summary, the solubility of 3-fluoro-4-methyl-aniline is influenced by its structural characteristics, particularly the balance between the polar fluorine atom and the hydrophobic aromatic system. Understanding these factors is crucial for predicting its behavior in various chemical environments.

Interesting facts

Interesting Facts about 3-Fluoro-4-methyl-aniline

3-Fluoro-4-methyl-aniline is a fascinating compound that belongs to the class of anilines, which are derived from ammonia by replacing one hydrogen atom with an aryl group. This compound exhibits unique properties due to its specific molecular structure and the presence of the fluorine and methyl groups. Here are some interesting facts:

  • Application in Dye Synthesis: 3-Fluoro-4-methyl-aniline is an important intermediate in the synthesis of various dyes and pigments. Its ability to undergo electrophilic substitutions makes it valuable in the dye industry.
  • Pharmaceutical Relevance: Compounds containing aniline structures are widely researched in pharmacology. The fluorine atom can enhance the pharmacokinetics of various drugs, making this compound of interest in medicinal chemistry.
  • Fluorine Effects: The incorporation of fluorine into organic compounds can lead to *increased stability* and *lower reactivity*, providing unique characteristics that can be exploited in material science.
  • Environmental Considerations: As with many aromatic amines, understanding the environmental impact is crucial. 3-Fluoro-4-methyl-aniline must be handled with care, as its disposal can be regulated due to its potential toxicity.
  • Synthetic Routes: Interestingly, the synthesis of this compound involves various approaches, such as the nucleophilic substitution of 4-methyl-aniline with a fluorinated reagent, showcasing the versatility in organic synthesis techniques.

Given its unique attributes and applications, 3-fluoro-4-methyl-aniline serves as a prime example of how small structural changes can lead to significant implications in chemistry and industry.

Synonyms
3-Fluoro-4-methylaniline
452-77-7
4-Amino-2-fluorotoluene
3-Fluoro-p-toluidine
Benzenamine, 3-fluoro-4-methyl-
2-Fluoro-4-aminotoluene
p-TOLUIDINE, 3-FLUORO-
EINECS 207-212-4
MFCD00007762
NSC 57470
BRN 2715987
3-fluoro-4-methylbenzenamine
DTXSID80196430
NSC-57470
3-fluoro-4-methyl-aniline
3-fluoro-4-methylphenylamine
NSC57470
3-Fluor-p-toluidin
Benzenamine, 3-fluoro-4-methyl- (9CI)
PCG9PMZ9Y7
3-fluoro-4-methyl aniline
WLN: ZR CF D1
SCHEMBL347254
3-fluoro-4-methyl-phenylamine
DTXCID90118921
3-Fluoro-4-methylaniline, 99%
BBL100253
STL195539
AKOS000113236
AC-3689
CS-W013514
PS-9194
Benzenamine, 3-fluoro-4-methyl-(9CI)
FF104392
SY013813
DB-024065
A7141
F0440
NS00043997
EN300-20223
3-Fluoro-4-methylbenzeneamine; 3-Fluoro-p-toluidine
F2190-0475
Z104477330