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3-Fluorophenol

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Identification
Molecular formula
C6H5FO
CAS number
372-20-3
IUPAC name
3-fluorophenol
State
State

At room temperature, 3-Fluorophenol is a liquid. However, it can crystallize into solid form near its melting point.

Melting point (Celsius)
33.50
Melting point (Kelvin)
306.65
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
112.11g/mol
Molar mass
112.1090g/mol
Density
1.2250g/cm3
Appearence

3-Fluorophenol is an organic compound with the appearance of a colorless to light yellow liquid. It has a phenolic odor which is characteristic of phenolic compounds. The liquid form is clear and may turn slightly brown upon exposure to air due to oxidation.

Comment on solubility

Solubility of 3-fluorophenol

3-fluorophenol, a monohydroxy aromatic compound, exhibits interesting solubility characteristics that are influenced by its molecular structure. This compound is known to be moderately soluble in water, primarily due to its ability to form hydrogen bonds. However, the presence of the fluorine atom can affect its solubility in various solvents.


Key Solubility Properties:

  • Water Solubility: 3-fluorophenol is soluble in water, allowing it to dissolve effectively in aqueous environments.
  • Organic Solvents: It shows good solubility in organic solvents like ethanol, methanol, and dichloromethane, making it versatile for various chemical applications.
  • Influence of Substituents: The electron-withdrawing effect of the fluorine atom enhances its solubility in polar solvents but can reduce solubility in non-polar solvents.

Overall, the solubility of 3-fluorophenol highlights its potential use in both industrial and laboratory settings, where its distinctive properties can be advantageous.

Interesting facts

Interesting Facts about 3-Fluorophenol

3-Fluorophenol, a notable halogen-substituted aromatic compound, exhibits some fascinating chemical properties and applications that make it a compound of interest in various fields of chemistry.

Chemical Significance

This compound is primarily characterized by the presence of a fluorine atom at the meta position of the phenolic ring. Such positioning can have profound effects on its chemical reactivity and physical properties compared to its ortho and para counterparts. Some key points include:

  • Enhancement of Reactivity: The electron-withdrawing nature of the fluorine atom can facilitate nucleophilic aromatic substitution reactions, making 3-fluorophenol more reactive toward certain reagents.
  • Acidity: The electron-withdrawing effect also influences the acidity of the compound, with 3-fluorophenol being a stronger acid than phenol, due to the stabilization of the phenoxide ion formed upon deprotonation.
  • Solvation Effects: The polar nature of the C-F bond can enhance solvation in polar solvents, impacting its behavior in various chemical environments.

Applications in Industry

3-Fluorophenol finds usage in several industrial applications:

  • Pharmaceuticals: It serves as an intermediate in the synthesis of various pharmaceutical compounds, where precise modifications of molecular structure are crucial for biological activity.
  • Agrochemicals: Its derivatives are employed in the production of agrochemicals, contributing to the development of effective insecticides and herbicides.
  • Material Sciences: This compound can be utilized in the development of materials that require specific chemical functionalities.

Environmental Considerations

The presence of fluorinated compounds in the environment raises important considerations. 3-Fluorophenol, like many other fluorinated compounds, may exhibit bioaccumulation potential, leading to concerns over ecological impact. As such, understanding its degradation pathways and environmental behavior is crucial for sustainable practices.

Conclusion

In summary, 3-fluorophenol is not just a simple aromatic compound; it represents a fascinating intersection of chemistry, environmental science, and industrial applications. Its unique properties, reactivity, and implications in various fields continue to spark interest among chemists and researchers alike.

Synonyms
3-FLUOROPHENOL
372-20-3
m-Fluorophenol
Phenol, 3-fluoro-
Phenol, m-fluoro-
3-FLUORO-PHENOL
meta-fluorophenol
MFCD00002254
T7OMA38487
EINECS 206-748-6
NSC 87078
NSC-87078
DTXSID70190684
UNII-T7OMA38487
m-fluoro-phenol
Phenol, mfluoro
3-Fluorphenol
3- fluorophenol
3-Fluoro phenol
Phenol, 3fluoro
3-Fluorophenol, 98%
Phenol, mfluoro (8CI)
Phenol, 3fluoro (9CI)
Phenol, m-fluoro-(8CI)
SCHEMBL5008
NCIOpen2_001026
Phenol, 3-fluoro-(9CI)
CHEMBL57342
DTXCID10113175
NSC87078
STL445671
AKOS000118865
CS-W020028
FF15570
PS-9255
s12316
AC-10889
BP-12002
DB-023954
F0159
NS00041739
EN300-19554
Q27289779
F0001-1069
206-748-6