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Isatin

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Identification
Molecular formula
C8H5NO2
CAS number
91-56-5
IUPAC name
3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione
State
State

At room temperature, Isatin is in a solid state.

Melting point (Celsius)
201.00
Melting point (Kelvin)
474.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
147.13g/mol
Molar mass
147.1410g/mol
Density
1.5000g/cm3
Appearence

Isatin is a red-orange solid compound.

Comment on solubility

Solubility of 3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione (C8H5NO2)

3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione is known to exhibit intriguing solubility characteristics. Understanding its solubility in various solvents can provide key insights into its reactivity and applications. Here are some important points regarding its solubility:

  • Water solubility: This compound is typically sparingly soluble in water, which is characteristic of many organic compounds due to their hydrophobic regions.
  • Organic solvents: 3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione shows better solubility in organic solvents such as ethanol, methanol, and acetone, where it can dissolve more readily.
  • Temperature dependence: Its solubility can be influenced by temperature, generally increasing with temperature due to enhanced molecular motion and interactions.
  • pH sensitivity: The solubility of this compound may vary with the pH of the solution, as the ionization of functional groups can significantly affect solubility.

Overall, the solubility of C8H5NO2 can be summarized as limited in aqueous solutions but favorable in polar organic solvents, which aligns with its structural characteristics.

Interesting facts

Interesting Facts about 3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione

3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione is a fascinating organic compound that belongs to the class of indoles, which are known for their diverse chemical properties and biological activities. Here are some intriguing aspects of this compound:

  • Biological Significance: Compounds in the indole family, such as this one, often play significant roles in biological functions. They can be involved in neurotransmissions, and many indole derivatives are known as important pharmaceutical agents.
  • Potential Applications: Due to specific structural characteristics, this compound may exhibit interesting pharmacological properties. Research has suggested that derivatives of 2,3-dihydroindole often show promise in medicinal chemistry, particularly in the development of anti-cancer and anti-inflammatory drugs.
  • Synthesis Routes: The synthesis of 3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione can be approached via several pathways, often involving condensation reactions with substituted anilines. The ability of scientists to manipulate its synthesis opens the door to creating various derivatives with altered properties.
  • Structural Features: The compound's structure features a dihydroindole framework that contributes to its stability and reactivity. This unique scaffold can be functionalized to display different chemical behaviors depending on the desired application.
  • Natural occurrence: Indole structures are commonly found in nature, including in plant alkaloids and amino acid tryptophan. Investigating how compounds like this fit into natural product chemistry can lead to the discovery of novel bioactive substances.

In summary, 3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione is more than just a simple compound; it embodies a rich potential for discoveries in both chemistry and pharmacology. Understanding its properties contributes to a broader knowledge of indoles and their applications in science.

Synonyms
Adrenochrome
54-06-8
Adraxone
D,L-Adrenochrome
3-Hydroxy-1-methyl-5,6-indolinedione
USAF uctl-7
3-Hydroxy-1-methylindoline-5,6-dione
1-Adrenochrome
EINECS 200-192-8
2,3-Dihydro-3-hydroxy-1-methyl-1H-indole-5,6-dione
1H-Indole-5,6-dione, 2,3-dihydro-3-hydroxy-1-methyl-
70G54NQL71
ADRENOCHROME [MI]
5,6-INDOLINEDIONE, 3-HYDROXY-1-METHYL-
3-hydroxy-1-methyl-2,3-dihydroindole-5,6-dione
NSC407840
3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione
3-hydroxy-1-methyl-2,3,5,6-tetrahydro-1H-indole-5,6-dione
Adrenochrom
UNII-70G54NQL71
ADRENOCHROME, L-
D,L-Adrenochrome - 90%
D,L-Adrenochrome - 98%
SCHEMBL61927
CHEMBL1314174
DTXSID00871530
CHEBI:166544
RPHLQSHHTJORHI-UHFFFAOYSA-N
BCP30577
MFCD00069732
NSC383491
AKOS006229902
FA17226
NSC-383491
NSC-407840
NCGC00163348-01
7506-92-5
DA-50243
FA165341
TS-08089
HY-116513
CS-0065676
NS00041209
A12617
Q366835
1H-Indole-5,6-dione, 2,3-dihydro-3-hydroxy-1-methyl-(9CI)
3-Hydroxy-1-methyl-5,6-indolinedione,2,3-dihydro-3-hydroxy-1-methyl-1H-indole-5,6-dione
200-192-8
D,L-Adrenochrome; 3-Hydroxy-1-methyl-5,6-indolinedione; 2,3-Dihydro-3-hydroxy-1-methyl-1H-indole-5,6-dione pound>>Phenylephrine Impurity 1 pound>>Adraxone