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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
State
State

At room temperature, corticosterone is a solid.

Melting point (Celsius)
181.00
Melting point (Kelvin)
454.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
346.47g/mol
Molar mass
346.4640g/mol
Density
1.2200g/cm3
Appearence

Corticosterone is a white to off-white crystalline powder. It is typically odorless and is sparingly soluble in water, but soluble in ethanol and methanol.

Comment on solubility

Solubility of 3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

The solubility of 3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one (C21H30O4) can be characterized as follows:

  • Polar vs. Nonpolar Solubility: Given its hydroxyl group (-OH), this compound exhibits some level of polarity which can enhance its solubility in polar solvents like water, albeit to a limited extent.
  • Hydrophobic Characteristics: The significant hydrophobic segments within its structure indicate that the compound may have a greater affinity for nonpolar solvents such as hexane or chloroform.
  • Solvent Interaction: It is likely to demonstrate variable solubility depending on the solvent system used; thus, it may dissolve well in organic solvents while showing *limited solubility in aqueous solutions*.

In summary, this compound’s solubility is dictated by a balance between its polar hydroxyl group and its predominantly hydrophobic hydrocarbon framework. It's essential to consider these factors when determining the best solvent for dissolution in various applications.

Interesting facts

Interesting Facts about 3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

This fascinating compound, often referred to in the context of steroid chemistry, has several notable aspects that pique the interest of both scientists and students alike. Here are some fun facts about this complex molecule:

  • Chemical Structure: The compound features a unique multi-ring structure characteristic of steroid frameworks, which contributes significantly to its biological activity. The presence of hydroxy groups further enhances its reactivity and potential interactions within biological systems.
  • Biological Importance: Derivatives and analogs of this compound are often studied for their potential roles in medicine, particularly relating to hormonal functions and influences on metabolic pathways, making them valuable targets in pharmaceutical research.
  • Synthetic Pathways: The complex synthesis of this compound showcases the ingenuity and creativity of organic chemists. It often involves several steps, including ring formations and functional group modifications, utilizing both traditional techniques and modern methodologies.
  • Applications: Due to its structural features, this compound has implications in both therapeutic and diagnostic applications—ranging from hormone replacement therapies to potential markers in disease diagnostics.
  • Intriguing Analogs: There is a wide range of related compounds in the steroid family which share similar structural characteristics but differ in functional groups, demonstrating the versatility and complexity of steroid chemistry.

As stated by renowned chemists, “The beauty of chemistry lies in the myriad of structures that arise from simple building blocks.” This compound is a perfect illustration of that grandeur in molecular architecture that captivates researchers and students alike!

Synonyms
3-Hydroxyandrost-5-en-17-one
3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
ITdU
Spectrum_000661
SpecPlus_000094
Spectrum2_000359
Spectrum3_000116
Spectrum4_001395
Spectrum5_000130
KBioGR_001750
KBioSS_001141
CHEMBL31399
DivK1c_006190
SPBio_000457
SCHEMBL9969169
CHEBI:95212
KBio1_001134
KBio2_001141
KBio2_003709
KBio2_006277
KBio3_000872
DTXSID801331866
CCG-38634
AKOS015998159
SMP2_000186
LS-14740
Q27167029