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Camptothecin

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Identification
Molecular formula
C20H16N2O4
CAS number
7689-03-4
IUPAC name
3-hydroxy-12-(3-hydroxy-4-methoxy-phenyl)-8,16,17-trimethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one
State
State
Solid at room temperature.
Melting point (Celsius)
264.00
Melting point (Kelvin)
537.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
348.35g/mol
Molar mass
348.3520g/mol
Density
1.3617g/cm3
Appearence

Crystalline solid, typically with a white to pale yellow color.

Comment on solubility

Solubility of 3-hydroxy-12-(3-hydroxy-4-methoxy-phenyl)-8,16,17-trimethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one

The solubility characteristics of the compound with the molecular formula C20H16N2O4 reveal intriguing properties due to its complex structure. Here are some key points regarding its solubility:

  • Water Solubility: Generally, compounds with multiple methoxy groups can exhibit varied solubility in water. However, due to the presence of both hydrophobic groups and polar hydroxyl groups, solubility in water is expected to be limited.
  • Organic Solvents: It is likely that the compound shows good solubility in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), owing to its lipophilic nature.
  • Effect of pH: The solubility may also be influenced by the pH of the solution. Alterations in pH can cause protonation or deprotonation of hydroxyl groups, impacting overall solubility.
  • Temperature Variations: Like many organic compounds, solubility may increase with elevated temperatures, which can enhance molecular interactions with the solvent.

In summary, while the precise solubility of this compound can vary, its structure indicates a tendency towards limited water solubility and better behavior in organic solvents, emphasizing the importance of environmental factors in determining its solubility.

Interesting facts

Interesting Facts About 3-Hydroxy-12-(3-hydroxy-4-methoxy-phenyl)-8,16,17-trimethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one

This fascinating compound showcases the complexity and beauty of organic chemistry. Here are some intriguing facts:

  • Structural Complexity: The compound features a unique azapentacyclic structure that is rarely encountered in nature, indicating a potential for interesting biological activities.
  • Hydroxyl Groups: With multiple hydroxyl groups present, it may exhibit strong hydrogen bonding, influencing its solubility and reactivity.
  • Potential Biological Properties: Compounds with similar structures have been studied for their medicinal properties. This one might possess antioxidant or anti-inflammatory capabilities, making it a candidate for pharmacological research.
  • Pharmacophore Insights: The presence of methoxy groups can enhance the lipophilicity of the compound, which is crucial in drug design to improve bioavailability.
  • Natural Product Inspiration: Nature often serves as a template for complex organic structures; thus, it’s worthwhile to investigate natural sources that may yield similar compounds.

In conclusion, the exploration of such intricate compounds not only deepens our understanding of organic chemistry but also opens doors to potential therapeutic applications. As emphasized by researchers: "The beauty of chemistry lies in its complexity and our quest to unravel its secrets."