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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
3-hydroxy-12-(4-hydroxy-3-methoxy-phenyl)-8,16,17,18-tetramethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one
State
State

At room temperature, colchicine is in a solid state. It is stable under standard conditions and does not evaporate or sublimate readily.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
352.00
Boiling point (Kelvin)
625.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4360g/mol
Density
1.3300g/cm3
Appearence

Colchicine is a pale yellow solid. It is often found in a crystalline form and is odorless. The pure compound is finely crystalline and typically has a slight sheen due to its crystalline structure.

Comment on solubility

Solubility of 3-hydroxy-12-(4-hydroxy-3-methoxy-phenyl)-8,16,17,18-tetramethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one (C22H25NO6)

The solubility of this complex organic compound can significantly influence its applications in various fields such as pharmaceuticals and materials science. Understanding its solubility profile is essential for optimal usage. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple methoxy groups and hydroxyl groups suggests moderate to high polarity, which may enhance solubility in polar solvents.
  • Solvent Interaction: The compound is likely soluble in polar solvents like ethanol and methanol, while possibly exhibiting limited solubility in non-polar organic solvents.
  • Hydrogen Bonding: The hydroxyl groups can participate in hydrogen bonding, which may aid in solubility in aqueous environments.
  • Temperature Dependence: Solubility may increase with temperature, as is common with many organic compounds, particularly those that are temperature-sensitive.

In conclusion, while the solubility of 3-hydroxy-12-(4-hydroxy-3-methoxy-phenyl)-8,16,17,18-tetramethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one can be generally anticipated based on its structural features, specific experimental determinations are necessary to characterize its solubility in various solvents.

Interesting facts

Exploring 3-Hydroxy-12-(4-hydroxy-3-methoxy-phenyl)-8,16,17,18-tetramethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one

This complex compound, often referred to in scientific literature for its intricate structure, belongs to a class of organic molecules notable for their diverse applications in pharmaceuticals and materials science. Here are some interesting facts about this fascinating chemical:

  • Diverse Functionalities: The compound contains multiple functional groups, including hydroxy and methoxy groups, which contribute to its potential biological activities, making it a subject of interest for medicinal chemistry.
  • Structural Complexity: Its unique pentacyclic structure indicates intricate bonding patterns. Such complex structures often exhibit interesting properties such as enhanced stability and unique reactivity.
  • Potential Applications: The compound has shown promise in fields such as drug development and organic synthesis, serving as a candidate for targeting specific biological pathways.
  • Natural Product Inspiration: Many compounds with similar structural features are derived from natural sources, leading scientists to explore their roles in ecological interactions and their potential medicinal properties.
  • Research Opportunities: The complexity of this molecule presents opportunities for further research, including synthesis, characterization, and studying its interactions within biological systems.
  • Interdisciplinary Appeal: This compound serves as a bridge between organic chemistry, medicinal chemistry, and material science, highlighting the interconnectedness of different chemical disciplines.

In conclusion, the exploration of 3-hydroxy-12-(4-hydroxy-3-methoxy-phenyl)-8,16,17,18-tetramethoxy-4-oxa-1-azapentacyclo[11.8.0.02,11.05,10.014,19]henicosa-2,5,8,10,12,14,16,18-octaen-7-one opens up avenues for innovation in pharmaceutical formulations and material development. As with many complex organic compounds, continued research could unveil exciting new uses and deepen our understanding of its properties.