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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
State
State

At room temperature, estrone is typically found as a solid.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.00
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.00
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2300g/cm3
Appearence

Estrone is a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

The solubility of 3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one (C18H22O2) can be characterized as follows:

  • Solvent Compatibility: This compound is expected to have moderate solubility in organic solvents due to its hydrophobic characteristics.
  • Water Solubility: It is likely to be poorly soluble in water, given the large hydrocarbon structure that dominates the molecular framework.
  • Temperature Effects: Increased temperature may enhance its solubility in certain organic solvents, enabling better dissolution.
  • Polarity Influence: The presence of the hydroxyl group makes it somewhat polar; however, the overall non-polar character can lead to limited aqueous compatibility.

In conclusion, while 3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one exhibits some solubility properties, its behavior in different solvents is primarily dictated by its structure. Therefore, testing in specific solvent systems is recommended for precise solubility data.

Interesting facts

Interesting Facts about 3-Hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

This intriguing compound is a steroid-like molecule that has caught the attention of chemists and biologists alike. Often associated with various biological activities, it presents a unique structure that merits deeper exploration. Here are some captivating details:

  • Biological Relevance: Compounds of this nature often play significant roles in biological systems, acting as precursor molecules for hormones and other steroids.
  • Structural Characteristics: The complexity of this molecule lies in its multi-ring configuration, which is characteristic of many steroids. This structure allows it to interact with biological receptors, facilitating various physiological processes.
  • Potential Therapeutic Applications: Research indicates that similar compounds may possess therapeutic properties, such as anti-inflammatory or anti-cancer effects. The quest to uncover these properties is ongoing and holds promise for future medicinal developments.
  • Synthesis Challenges: The synthesis of such polycyclic compounds is a fascinating area of study. Synthetic chemists often encounter challenges related to stereochemistry and yield, pushing the boundaries of organic synthesis methodologies.

As the famous chemist Linus Pauling once said, "The best way to have a good idea is to have lots of ideas." This sentiment rings true in the study of complex compounds like this one, where each interaction and application can lead to new discoveries in the field of chemistry and pharmacology.

In conclusion, the exploration of 3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one opens up doors to a plethora of scientific inquiries and potential innovations, making it a compound worth studying.

Synonyms
Menformon A
E1;Oestrone
NSC9699
Ketohydroxy-Estratriene
Unden (pharmaceutical)
Follidrin (tablets)
1187829-63-5
3-Hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17h-cyclopenta[a]phenanthren-17-one
Estrone-[2,3,4-13C3]
Fermidyn
1,3,5-Oestratrien-3-ol-17-one
Femestrone inj.
MFCD00003620
NCGC00015423-03
Duogen (Salt/Mix)
ST019426
component of Spanestrin-P
CHEMBL756
Oprea1_745128
MLS001331716
SCHEMBL157262
CHEBI:95131
DNXHEGUUPJUMQT-UHFFFAOYSA-N
HMS2235H07
HMS3370A22
GCA58858
3-Hydroxy-17-ketoestra-1,5-triene
3-Hydroxy-17-ketooestra-1,5-triene
AKOS001116292
1,5(10)-Estratrien-3-ol-17-one
1,5(10)-Oestratrien-3-ol-17-one
3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
5-hydroxy-15-methyltetracyclo[8.7.0.0<2,7>.0<11,15>]heptadeca-2(7),3,5-trien-1 4-one
NCGC00015423-02
NCGC00142363-01
NCGC00142363-02
3-Hydroxyestra-1,5(10)-trien-17-one
SMR000814705
SY036249
3-Hydroxy-1,5(10)-oestratrien-17-one
WLN: L E5 B666 FVTTT&J E1 OQ
3-Hydroxy-oestra-1,5(10)-trien-17-one
3-Hydroxy-1,3,5(10)-oestratrien-17-one
CS-0348902
.delta.-1,5-Estratrien-3.beta.-ol-17-one
delta-1,3,5-Estratrien-3.beta.-ol-17-one
EN300-18760
Estra-1,5(10)-trien-17-one, 3-hydroxy-
.delta.-1,5-Oestratrien-3.beta.-ol-17-one
delta-1,3,5-Oestratrien-3.beta.-ol-17-one
.DELTA.-1,3,5(10)-Estratrien-3-ol-17-one
BRD-A14458579-001-08-5
Q27166915
5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-14-one