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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one
State
State
Corticosterone is a solid at room temperature.
Melting point (Celsius)
184.50
Melting point (Kelvin)
457.70
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
346.46g/mol
Molar mass
346.4630g/mol
Density
1.2900g/cm3
Appearence

Corticosterone appears as a white crystalline powder. It is odorless and soluble in organic solvents such as ethanol and chloroform but only slightly soluble in water.

Comment on solubility

Solubility of 3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one

The solubility of 3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one can be quite intricate due to its complex molecular structure. Here are some key considerations regarding its solubility:

  • Solubility in Water: This compound is likely to exhibit low solubility in water because of its predominantly hydrophobic character. The presence of multiple hydrocarbon rings can contribute to a decreased interaction with polar solvents.
  • Solubility in Organic Solvents: Conversely, it may demonstrate good solubility in organic solvents such as ethanol, methanol, and acetone. Compounds with significant non-polar characteristics generally dissolve well in non-polar or slightly polar solvents.
  • Temperature Effects: Temperature may play a crucial role in its solubility profile, potentially enhancing solubility in organic solvents as the temperature increases.

In conclusion, while 3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one's solubility can vary significantly with the solvent type and environmental conditions, it typically favors organic environments over aqueous solutions.

Interesting facts

Interesting Facts About 3-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one

This compound, with a complex molecular structure, showcases the beauty and intricacy of organic chemistry, particularly in the realm of steroids and their derivatives. Here are some fascinating insights into its characteristics and significance:

  • Chemical Structure: The title of this compound implies an elaborate molecular architecture featuring multiple functional groups and a steroid skeleton, making it a subject of interest in the study of hormone analogs.
  • Biological Activity: Compounds like this often exhibit significant biological properties. Many steroids can have effects on a variety of physiological processes, including metabolism and immune response.
  • Potential Applications: Due to its complex nature, this compound may have applications in drug design, particularly in developing therapeutic agents targeting hormone-related pathways.
  • Analytical Techniques: To study and characterize such a compound, chemists often employ sophisticated techniques such as NMR (Nuclear Magnetic Resonance) spectroscopy, Mass Spectrometry, and X-ray Crystallography.
  • Synthetic Challenges: The synthesis of this molecule may involve multiple steps and require advanced synthetic methodologies. It's a great example of the challenges chemists face in creating complex organic molecules.
  • A historical perspective: The study of such compounds aids in understanding the evolution of steroid-based medications, which have been instrumental in modern medicine.

The compound serves as a reminder of the wonders of organic synthesis and the endless possibilities it holds for medical and scientific advancement. As chemists continue to explore its properties, we may uncover more of its secrets, leading to innovative therapies that improve human health.

Synonyms
3,21-dihydroxypregnane-11,20-dione
DTXSID20864469
AKOS024319489
NS00084516
G92426
(3alpha)-3,21-dihydroxypregnane-11,20-dione