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3-Hydroxy-3-(2-pyridylmethyl)indolin-2-one

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Identification
Molecular formula
C14H12N2O2
CAS number
null
IUPAC name
3-hydroxy-3-(2-pyridylmethyl)indolin-2-one
State
State

At room temperature, 3-Hydroxy-3-(2-pyridylmethyl)indolin-2-one exists as a solid. It is stable under normal temperatures and pressures.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.00
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.00
General information
Molecular weight
252.27g/mol
Molar mass
252.2740g/mol
Density
1.3213g/cm3
Appearence

This compound typically appears as a white to off-white crystalline solid.

Comment on solubility

Solubility of 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one

The solubility of 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one in various solvents can provide important insights into its chemical behavior and potential applications. Generally, the solubility characteristics can be influenced by several factors:

  • Polarity: Given that this compound contains a hydroxyl (-OH) group and a pyridine moiety, it is likely to exhibit varying solubility in polar and nonpolar solvents.
  • Hydrogen Bonding: The presence of the hydroxyl group allows for the formation of hydrogen bonds with solvents such as water and alcohols, enhancing solubility in these polar solvents.
  • Solvent Effects: Its solubility may be higher in organic solvents like dimethyl sulfoxide (DMSO) or dimethylformamide (DMF) compared to more standard solvents.

As a comparison, compounds with similar functional groups often exhibit typical solubility patterns:

  1. Highly polar compounds: Tend to dissolve well in water and other polar solvents.
  2. Nonpolar compounds: Usually have low solubility in water but can dissolve in organic solvents.
  3. Amphiphilic compounds: Display varying solubility trends depending on the solvent composition.

It is important to consider these factors when determining the solubility of 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one in various contexts, such as synthesis and pharmaceutical formulation. Therefore, conducting experimental solubility tests in multiple solvents can yield crucial data, providing a clearer understanding of its solubility profile. As it is often stated, “solubility can dictate the pathway of a molecular journey,” making it a fundamental property to study.

Interesting facts

Interesting Facts about 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one

The compound 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one, often abbreviated to its more manageable core structure, has garnered significant interest in the field of medicinal chemistry.

Unique Structural Features

  • Indole Framework: The presence of the indolin-2-one core provides a foundation that enhances biological activity.
  • Pyridine Interaction: The 2-pyridylmethyl group plays a crucial role in receptor binding, making this compound a candidate for drug design.
  • Hydroxyl Group: The hydroxy functionality can participate in hydrogen bonding, influencing solubility and interaction with biological targets.

Biological Activities

This compound has been studied for various potential biological activities, particularly:

  • Anticancer Properties: Preliminary studies suggest it may exhibit activity against certain cancer cell lines.
  • Antimicrobial Effects: Research indicates potential efficacy in inhibiting the growth of specific microbial strains.
  • Neuroprotective Potential: There is promise in exploring its effects on neurodegenerative diseases.

Applications in Drug Design

Given its unique molecular structure, 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one serves as an interesting scaffold for further modifications aimed at improving pharmacological properties. The flexibility in the indolin-2-one structure makes it a suitable candidate for:

  • Designing novel therapeutic agents
  • Developing selective kinase inhibitors
  • Creating compounds targeting specific biological pathways

Research and Future Directions

Continued research into 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one will likely unveil further applications and enhance our understanding of its mechanisms of action. As the need for innovative drug solutions grows, compounds such as this could be pivotal in overcoming current medical challenges.

In conclusion, the exploration of 3-hydroxy-3-(2-pyridylmethyl)indolin-2-one not only highlights the beauty of chemical structures in nature but also exemplifies the intersection of chemistry and medicine in the pursuit of advanced therapeutic solutions.

Synonyms
ALPHA-(3-HYDROXY-2-OXO-3-INDOLINYL)-2-METHYLPYRIDINE
654-834-0
6299-00-9
NSC42448
3-hydroxy-3-(pyridin-2-ylmethyl)-1H-indol-2-one
3-Hydroxy-3-(2-pyridylmethyl)-2-indolinone
3-Hydroxy-3-(pyridin-2-ylmethyl)indolin-2-one
MLS000737059
NSC631609
3-Hydroxy-3-(2-pyridinylmethyl)-1,3-dihydro-2H-indol-2-one
NSC 42448
BRN 0210266
NSC-42448
2-INDOLINONE, 3-HYDROXY-3-(2-PYRIDYLMETHYL)-
alpha-(2-Oxo-3-hydroxy-indolinyl-(3))-2-methyl pyridine
Maybridge1_006274
Oprea1_067199
4-25-00-00176 (Beilstein Handbook Reference)
SCHEMBL734231
3-hydroxy-3-pyridin-2-ylmethyl-1,3-dihydroindol-2-one
CHEMBL1902669
HMS559F04
NGKGBFMNFGPGGV-UHFFFAOYSA-N
HMS2754K03
AKOS024323320
CCG-248595
NSC-631609
NCI60_003972
SMR000394014
3-hydroxy-3-(2-pyridylmethyl)indolin-2-one
AE-473/30684046
3-hydroxy-3-(pyridin-2-ylmethyl)-1,3-dihydro-2H-indol-2-one