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Ambroxol

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Identification
Molecular formula
C13H18BrClN2O
CAS number
23828-92-4
IUPAC name
[3-hydroxy-3-phenyl-3-(2-thienyl)propyl]-trimethyl-ammonium
State
State

At room temperature, Ambroxol hydrochloride is typically found in a solid state.

Melting point (Celsius)
233.00
Melting point (Kelvin)
506.00
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.00
General information
Molecular weight
314.86g/mol
Molar mass
314.8580g/mol
Density
1.0700g/cm3
Appearence

Ambroxol hydrochloride appears as a white or slightly yellow crystalline powder. It is typically tasteless and has a faint odor.

Comment on solubility

Solubility of [3-hydroxy-3-phenyl-3-(2-thienyl)propyl]-trimethyl-ammonium

The solubility of the compound [3-hydroxy-3-phenyl-3-(2-thienyl)propyl]-trimethyl-ammonium can be influenced by multiple factors given its complex structure. This quaternary ammonium compound features a positively charged nitrogen atom, which typically enhances its interactions with polar solvents. Here’s a closer look at its solubility characteristics:

  • Polarity: The presence of hydroxyl (–OH) groups contributes to the compound's polarity, potentially increasing solubility in polar solvents like water.
  • Hydrogen Bonding: The –OH group can form hydrogen bonds, which can further enhance solubility in aqueous solutions.
  • Organic Solvents: Solubility in organic solvents may vary. Non-polar solvents may exhibit lower solubility due to the polar nature of the molecule.
  • Temperature: Increasing temperature generally increases the solubility of many compounds, thus adjustments could be necessary in experimental conditions.

To summarize, while [3-hydroxy-3-phenyl-3-(2-thienyl)propyl]-trimethyl-ammonium might be expected to demonstrate a certain degree of solubility in polar solvents due to its structural features, specific solubility patterns can only be confirmed through empirical testing to understand the full extent of its solubilization characteristics in various environments.

Interesting facts

Interesting Facts about [3-Hydroxy-3-phenyl-3-(2-thienyl)propyl]-trimethyl-ammonium

The compound [3-hydroxy-3-phenyl-3-(2-thienyl)propyl]-trimethyl-ammonium is a fascinating quaternary ammonium compound that brings together organic chemistry with medicinal applications. Its structure features unique functional groups that contribute to its chemical behavior and potential uses.

Unique Features

  • Quaternary Ammonium Structure: Being a quaternary ammonium compound, it has a positively charged nitrogen center that can interact favorably with various biological molecules.
  • Functional Groups: The presence of a hydroxyl group and aromatic rings (phenyl and thienyl) enhances the compound's reactivity and solubility in biological systems.
  • Potential Pharmaceutical Use: This compound may exhibit properties of interest in medicinal chemistry, including antimicrobial or antiviral activities, owing to its unique structure.

Applications and Research

Quaternary ammonium compounds are widely utilized as:

  • Antiseptics: Their ability to disrupt microbial cell membranes makes them effective in disinfectants.
  • Cationic Surfactants: They are employed in formulations to enhance solubilization and stability.
  • Drug Delivery Systems: The charged nitrogen atom allows for enhanced interaction with negatively charged biological membranes, potentially improving drug absorption.

As a chemist or student exploring this compound, it is essential to consider the evolutionary path of the compound itself, understanding how synthetic modifications can lead to enhanced therapeutic properties.

In summary, [3-hydroxy-3-phenyl-3-(2-thienyl)propyl]-trimethyl-ammonium stands as an intriguing example of how chemical design can lead to innovations in pharmaceutical sciences. As stated by renowned chemist Robert H. Grubbs, "The best way to learn chemistry is to integrate theory with practice." Thus, delving into such compounds can offered enlightening intersections across disciplines.