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Cidofovir

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Identification
Molecular formula
C8H14N3O6P
CAS number
113852-37-2
IUPAC name
[3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate
State
State

At room temperature, Cidofovir is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
279.00
Melting point (Kelvin)
552.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
315.19g/mol
Molar mass
315.2100g/mol
Density
2.0406g/cm3
Appearence

The compound Cidofovir typically appears as a white crystalline solid.

Comment on solubility

Solubility of [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate

The solubility of the compound, represented by the formula C8H14N3O6P, can be quite intriguing due to its complex structure. This compound contains various functional groups that can influence its solubility in different solvents.

Factors Influencing Solubility

  • Polarity: Given the presence of hydroxyl (-OH) and phosphate (-P) functional groups, the compound is expected to have increased solubility in polar solvents like water.
  • Hydrogen Bonding: The -OH group allows for hydrogen bonding, promoting solubility in aqueous environments.
  • Hydrophobic Regions: The molecule also contains hydrophobic components, which may reduce solubility in water but enhance solubility in organic solvents.

Expected Solubility Behavior

Based on the structural characteristics, we can deduce:

  • The compound is likely to be soluble in polar solvents, particularly in water.
  • In organic solvents, solubility may vary significantly depending on the degree of hydrophobic interactions.
  • Overall, the solubility spectrum is broad and could be tailored by adjusting conditions such as pH or mixing with compatible solvents.

In conclusion, the solubility of [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate is influenced by its functional groups and molecular structure, leading to varying solubility in different environments.

Interesting facts

Exploring [3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate

This compound, widely known for its complex structure, combines elements of organic chemistry with those of phosphoric acid derivatives. Below are some intriguing facts regarding this fascinating molecule:

  • Diverse Applications: This compound is involved in biological processes and has potential applications in medicinal chemistry, particularly in drug design and development.
  • Pyrimidine Derivative: The presence of a pyrimidine ring adds to the compound's **biological significance**, as pyrimidines are key components of nucleic acids, involved in energy metabolism and cellular functions.
  • Phosphate Group: The inclusion of a dihydrogen phosphate moiety is critical, as phosphates are vital in biochemical pathways, especially in the formation of nucleotides, which play a central role in DNA and RNA biosynthesis.
  • Structure-Activity Relationship: The unique structural features allow for the exploration of structure-activity relationships (SAR), making it a valuable compound for researchers studying the efficacy of drugs.
  • Potential for Synthesis: The synthetic pathways leading to this compound can yield insights into novel synthesis methods and catalytic processes in organic chemistry.

As a scientist or chemistry student examining this compound, one can appreciate the interplay of organic and inorganic chemistry concepts, shedding light on how subtle modifications in molecular structures can lead to significant biological effects. This compound embodies the essential principle that the structure of a molecule can dictate its reactivity and potential applications.

In the words of chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." Exploring such intricate compounds encourages creativity and innovation in scientific research.

Synonyms
Thymidine 5'MP
thymidine 5'-monophos-phate
SCHEMBL16092807
DTXSID10861902
CHEBI:181566
NSC46713
[3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
L001240
1-(2-Deoxy-5-O-phosphonopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione