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Tolterodine tartrate

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Identification
Molecular formula
C10H12N2O4
CAS number
56296-78-7
IUPAC name
3-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione
State
State

At room temperature, Tolterodine is usually a solid in the form of a crystalline powder, indicative of its high purity in its most common forms.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.00
Boiling point (Celsius)
156.00
Boiling point (Kelvin)
429.00
General information
Molecular weight
259.28g/mol
Molar mass
259.2750g/mol
Density
1.2930g/cm3
Appearence

Tolterodine is typically seen as a white to off-white crystalline solid that is highly soluble in water. In powder form, it appears fine and homogeneous.

Comment on solubility

Solubility of 3-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione

The solubility of 3-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione is an intriguing subject due to its unique molecular structure. Solubility can be influenced by various factors, including polarity, hydrogen bonding, and the presence of functional groups. In this case, there are several aspects to consider:

  • Polarity: The presence of hydroxymethyl groups increases the polarity of the compound, enhancing its affinity for polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water or other polar solvents can significantly enhance solubility. The hydroxymethyl group is particularly effective in this regard.
  • Structural Considerations: The spirocyclic structure may introduce steric hindrance, which could limit solubility in certain conditions.

In general, it is expected that 3-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione would exhibit better solubility in polar solvents such as water and alcohols due to the following:

  • Hydrophilicity from hydroxymethyl groups
  • Potential for solvation and interaction with solvent molecules

However, it may face challenges in non-polar solvents, where the hydrophobic regions of the molecule do not favor solubility. As with many compounds, experimental solubility testing is essential to ascertain the actual solubility characteristics in different solvents.

Interesting facts

Interesting Facts about 3-(Hydroxymethyl)-1,3-Diazaspiro[4.5]decane-2,4-dione

The compound 3-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione presents a fascinating structure and unique properties that make it a point of interest in the field of organic chemistry. Here are some key highlights:

  • Structural Uniqueness: This compound features a spiro architecture, showcasing how different functional groups can be integrated into a cyclic system.
  • Diverse Chemistry: The presence of two nitrogen atoms in the diazaspiro unit introduces interesting reactivity, particularly in the formation of coordination complexes.
  • Potential Applications: With its complex framework, this compound might have applications in pharmaceuticals, particularly as a scaffold for drug development.
  • Hydroxymethyl Group: The hydroxymethyl (-CH2OH) functional group can significantly influence the compound's reactivity and solubility, making it a pivotal site for further chemical modifications.
  • Research Interest: The study of diazaspiro compounds is an emerging field in medicinal chemistry, prompting scientists to explore their biological activity and potential therapeutic benefits.

Given these points, the study of 3-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione reveals a rich tapestry of interactions that can be explored further. As chemists delve into its properties and reactions, new discoveries and applications are on the horizon. This compound is not just a simple molecular formula; rather, it embodies the exciting complexities found at the intersection of innovative chemistry and practical applications.

Synonyms
710-86-1
1,3-DIAZASPIRO(4.5)DECANE-2,4-DIONE, 3-(HYDROXYMETHYL)-
BRN 0746656
3'-(Hydroxymethyl)cyclohexanespiro-5'-hydantoin
NSC600002
3-(Hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione
DTXSID90221227
NSC-600002