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3-Hydroxyquinoline-4-carboxylic acid

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Identification
Molecular formula
C10H7NO3
CAS number
491-35-0
IUPAC name
3-hydroxyquinoline-4-carboxylic acid
State
State
At room temperature, 3-hydroxyquinoline-4-carboxylic acid is found in a solid crystalline state.
Melting point (Celsius)
258.00
Melting point (Kelvin)
531.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
189.17g/mol
Molar mass
189.1670g/mol
Density
1.3940g/cm3
Appearence

3-Hydroxyquinoline-4-carboxylic acid typically appears as a beige to brown crystalline solid. Its solid form is characterized by the presence of fine, slightly colored crystals.

Comment on solubility

Solubility of 3-hydroxyquinoline-4-carboxylic acid

3-hydroxyquinoline-4-carboxylic acid, a compound of interest in the field of pharmaceuticals and chemistry, exhibits distinct solubility properties that are worth considering. Understanding its solubility behavior can be crucial for its applications.

Key Solubility Characteristics:

  • Solvent Compatibility: This compound is generally soluble in polar solvents such as water and methanol, making it useful in various aqueous formulations.
  • pH Dependence: The solubility can be significantly affected by the pH of the solution. At higher pH levels, the carboxylic acid group tends to deprotonate, enhancing solubility through ionization.
  • Crystallization: It may form stable crystalline structures in non-polar solvents, where it demonstrates lower solubility.

To summarize, the solubility of 3-hydroxyquinoline-4-carboxylic acid is influenced by both solvent polarity and solution pH, which can aid scientists and researchers in selecting the right environment for its optimal use. Proper understanding of these solubility dynamics can facilitate its application in drug development and other chemical processes.

Interesting facts

Interesting Facts about 3-Hydroxyquinoline-4-Carboxylic Acid

3-Hydroxyquinoline-4-carboxylic acid is a fascinating compound that holds significant importance in various fields of chemistry and biochemistry. Here are some intriguing aspects of this compound:

  • Biological Significance: This compound is known for its role as a precursor in the synthesis of numerous bioactive molecules, making it a valuable starting material in drug discovery and development.
  • Fluorescent Properties: 3-Hydroxyquinoline-4-carboxylic acid exhibits unique fluorescent properties that can be exploited in various applications, including fluorescence microscopy and analytical chemistry.
  • Metal Complexation: The compound has been studied for its ability to form complexes with metal ions. Such metal-chelating properties are essential in fields like coordination chemistry and materials science.
  • Research Utility: This compound has gained attention for its use in studies related to enzyme inhibition, especially in the context of antibacterial and antifungal activities.
  • Historical Context: Quinoline derivatives have been recognized for over a century, and the incorporation of hydroxyl and carboxylic acid functionalities has led to a better understanding of their reactivity and potential medicinal applications.

In essence, 3-hydroxyquinoline-4-carboxylic acid is more than just a chemical compound; it is a gateway to exploring a myriad of chemical reactions and biological interactions that can pave the way for innovative solutions in healthcare and materials science.

Synonyms
3-Hydroxyquinoline-4-carboxylic acid
118-13-8
3-Hydroxy-4-quinolinecarboxylic acid
3-Hydroxycinchoninic acid
CINCHONINIC ACID, 3-HYDROXY-
4-Quinolinecarboxylic acid, 3-hydroxy-
6QJT7K2GZG
4-Quinolinecarboxylicacid, 3-hydroxy-
EINECS 204-236-7
BRN 0154787
MFCD01536959
3-hydroxy-quinoline-4-carboxylic acid
UNII-6QJT7K2GZG
Oprea1_433704
4-22-00-02296 (Beilstein Handbook Reference)
SCHEMBL1759028
DTXSID40151989
3-Hydroxyquinoline-4-carboxylicacid
BCP25131
AKOS001607938
AB09188
CCG-104143
PS-11321
DB-081670
CS-0217930
EU-0035106
NS00023801
EN300-93470
G10446
Z1198157009
204-236-7