Skip to main content

Berberine

ADVERTISEMENT
Identification
Molecular formula
C20H18NO4
CAS number
2086-83-1
IUPAC name
3-isoquinolin-2-ium-2-ylpropyl(trimethyl)ammonium
State
State

At room temperature, berberine is a solid. It exists in a stable crystalline form and is often handled as such for medicinal and dye applications.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.00
Boiling point (Celsius)
506.00
Boiling point (Kelvin)
779.00
General information
Molecular weight
336.36g/mol
Molar mass
336.3610g/mol
Density
1.2600g/cm3
Appearence

Berberine is a bright yellow, crystalline compound. It is often used as a dye due to its striking color. In pure form, it is typically administered as a chloride or sulfate salt due to its poor solubility in water.

Comment on solubility

Solubility of 3-isoquinolin-2-ium-2-ylpropyl(trimethyl)ammonium

The solubility of 3-isoquinolin-2-ium-2-ylpropyl(trimethyl)ammonium is influenced by its ionic nature and the presence of multiple functional groups. As a quaternary ammonium compound, it generally exhibits the following solubility characteristics:

  • Soluble in Water: Quaternary ammonium ions typically show good solubility in polar solvents like water due to their positive charge, which helps to interact with water molecules.
  • Solubility in Organic Solvents: The solubility might vary in organic solvents; however, it often remains somewhat limited due to steric hindrance presented by the trimethyl groups.
  • Temperature Dependence: The solubility of this compound can also vary with temperature, likely increasing at elevated temperatures as molecular interactions weaken.

It's important to note that the specific solubility in particular solvents should be examined through experimental measurement, as subtle structural variations can significantly affect solubility behavior. As the saying goes, "The solution to solubility is often in the solvent itself!"


In summary, the solubility of 3-isoquinolin-2-ium-2-ylpropyl(trimethyl)ammonium can be largely interpreted through the lens of its ionic structure, highlighting the necessity of context in its applications and utility in chemical processes.

Interesting facts

3-Isoquinolin-2-ium-2-ylpropyl(trimethyl)ammonium: An Intriguing Compound

The compound 3-isoquinolin-2-ium-2-ylpropyl(trimethyl)ammonium represents a fascinating intersection between organic chemistry and biochemistry. This quaternary ammonium salt is characterized by its unique functional groups and structural complexity, making it a focus of interest in various research fields.

Key Characteristics

  • Biological Activity: Many ammonium salts are known for their roles as surfactants or antimicrobial agents.
  • Isoquinoline Structural Influence: The isoquinoline moiety is often associated with pharmacological activity, contributing to the exploration of potential therapeutic applications.
  • Polarity and Solubility: The quaternization of nitrogen increases the overall polarity of the molecule, which can influence its interactions with biological membranes.

Researchers are particularly interested in how this compound could pave the way for the development of novel pharmaceuticals. The combination of an isoquinoline backbone with a trimethylammonium group can lead to a range of biological effects, potentially opening doors to new treatments in areas such as:

  • Neuropharmacology
  • Anti-inflammatory therapies
  • Antimicrobial applications

As we continue to investigate the properties and potential uses of 3-isoquinolin-2-ium-2-ylpropyl(trimethyl)ammonium, it stands as a testament to the intricate design of chemical compounds and their extensive capabilities in scientific innovation. As the chemist Marie Curie once noted, "Nothing in life is to be feared, it is only to be understood." Understanding this compound today could very well lead to groundbreaking discoveries tomorrow.