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Fluorometholone acetate

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Identification
Molecular formula
C22H29FO4
CAS number
426-13-1
IUPAC name
3-methoxy-13-methyl-17-(1,2,2-trifluorovinyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
State
State

At room temperature, Fluorometholone acetate is typically found in the solid state. It is used primarily in this form for pharmaceutical preparations, particularly for ophthalmic suspensions to be used in eye treatments.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
385.00
Boiling point (Kelvin)
658.15
General information
Molecular weight
403.46g/mol
Molar mass
403.4330g/mol
Density
1.3000g/cm3
Appearence

Fluorometholone acetate typically appears as a white to off-white powder. The powder is crystalline in nature, indicating its purity and chemical composition. It is often used in a finely milled form to maximize its surface area for pharmacological applications.

Comment on solubility

Solubility of 3-methoxy-13-methyl-17-(1,2,2-trifluorovinyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol

The solubility of the compound 3-methoxy-13-methyl-17-(1,2,2-trifluorovinyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol can be understood through various factors that influence its interaction with solvents. Here are some key points to consider:

  • Polarity: The presence of polar functional groups, like the methoxy (-OCH3) and hydroxyl (-OH) groups, can enhance the solubility of this compound in polar solvents such as water or alcohols.
  • Hydrophobic Character: The bulky hydrocarbon structure provides a substantial hydrophobic component, which can limit solubility in polar environments.
  • Fluorine Substituents: The introduction of trifluorovinyl could increase the propensity for solubility in organic solvents due to its unique electronic characteristics, potentially leading to complex solvent interactions.

Overall, it is anticipated that 3-methoxy-13-methyl-17-(1,2,2-trifluorovinyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol may exhibit:

  1. A moderate solubility in polar solvents.
  2. Higher solubility in non-polar or less polar organic solvents.

While the precise solubility can greatly depend on experimental conditions such as temperature, pressure, and the specific solvent used, understanding these interactions helps predict its behavior in various chemical environments.

Interesting facts

Interesting Facts About 3-methoxy-13-methyl-17-(1,2,2-trifluorovinyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol

This intriguing compound belongs to a class of chemicals known for their complex structures and potential applications in medicinal chemistry. Here are some interesting facts that highlight the significance and uniqueness of this compound:

  • Complex Structure: The structure of this compound features multiple fused rings, providing it with unique chemical properties that are often studied for their effects on biological systems.
  • Fluorinated Groups: The presence of a trifluorovinyl group is notable since fluorinated compounds often exhibit enhanced metabolic stability and bioactivity, making them valuable in pharmaceutical development.
  • Applications in Medicinal Chemistry: Due to its structural features, this compound may exhibit activity against various diseases, reinforcing the importance of structure-activity relationships in drug design.
  • Research Potential: The compound's elaborate configuration opens the door to extensive research opportunities, particularly within fields such as organic synthesis and materials science.

As you explore the characteristics and applications of this compound, keep in mind that the design of complex molecules often leads to remarkable discoveries in both fundamental science and applied research. Its study could uncover new pathways in understanding both chemical behavior and therapeutic potential.

Synonyms
NCIOpen2_008770