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Nicorandil

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Identification
Molecular formula
C8H9N3O6K
CAS number
65141-46-0
IUPAC name
3-methyl-2-(1-naphthyl)-2-[2-(1-piperidyl)ethyl]butanenitrile
State
State

At room temperature, Nicorandil exists as a solid. Its formulation as a pharmaceutical compound is typically in tablet form for ease of administration and dosage control.

Melting point (Celsius)
92.50
Melting point (Kelvin)
365.65
Boiling point (Celsius)
477.15
Boiling point (Kelvin)
750.30
General information
Molecular weight
211.24g/mol
Molar mass
211.2390g/mol
Density
1.1200g/cm3
Appearence

Nicorandil is a white to off-white crystalline powder. It is typically highly soluble in water, which is a characteristic of many pharmaceutical compounds, aiding in its formulation as a medication.

Comment on solubility

Solubility of 3-methyl-2-(1-naphthyl)-2-[2-(1-piperidyl)ethyl]butanenitrile

The solubility of 3-methyl-2-(1-naphthyl)-2-[2-(1-piperidyl)ethyl]butanenitrile can be influenced by various factors due to its complex molecular structure. Understanding these solubility characteristics is essential for applications in pharmaceuticals and chemical research. Here are some key points regarding its solubility:

  • Polarity: The presence of both a naphthyl group and a piperidyl group suggests that the compound may have a relatively low polarity, which often results in low solubility in polar solvents such as water.
  • Organic Solvents: It is likely to be more soluble in organic solvents such as ethanol, methanol, and dichloromethane, which can solvate the hydrophobic aromatic and aliphatic portions of the molecule.
  • Temperature Effects: The solubility of organic compounds generally increases with temperature. Therefore, heating the solvent may enhance the dissolution of this compound.
  • pH Effects: If the compound has basic or acidic functionalities, the pH of the solution may significantly affect its ionization and, consequently, its solubility.

In summary, the solubility of 3-methyl-2-(1-naphthyl)-2-[2-(1-piperidyl)ethyl]butanenitrile is expected to be low in water but may show higher solubility in non-polar to moderately polar organic solvents. The interactions between the compound and the solvent, as well as external factors like temperature and pH, play crucial roles in determining its solubility profile.

Interesting facts

Interesting Facts about 3-Methyl-2-(1-naphthyl)-2-[2-(1-piperidyl)ethyl]butanenitrile

This compound, known for its intricate structure and unique properties, is a fascinating subject of study within the field of chemistry. Here are some engaging aspects to consider:

  • Pharmaceutical Potential: This compound falls within a class of chemicals that have been explored for their medicinal properties, particularly as potential agents in the treatment of neurological disorders. Its structural complexity offers a rich avenue for research and development.
  • Structural Features: The presence of the naphthyl group introduces aromaticity, which contributes to the compound's stability and can affect its interaction with biological targets. Additionally, the piperidyl side chain is known for providing diverse biological activity.
  • Synthesis Challenges: The synthesis of this compound can be quite challenging due to its multi-functional structure. Chemists often need to devise novel synthetic routes to efficiently create it, making it a valuable exercise in organic synthesis techniques.
  • Structure-Activity Relationship (SAR): Understanding how structural modifications impact the biological activity is crucial for optimizing the efficacy of similar compounds. This compound serves as an excellent case study for SAR analyses.

In summary, 3-methyl-2-(1-naphthyl)-2-[2-(1-piperidyl)ethyl]butanenitrile not only showcases the beauty of chemical complexity but also plays a critical role in advancing our understanding of medicinal chemistry and potential therapeutic applications.

Synonyms
2572-77-2
NSC 171376
BRN 1352307
1-NAPHTHALENEACETONITRILE, alpha-ISOPROPYL-alpha-(2-PIPERIDINOETHYL)-
NSC171376
alpha-Isopropyl-alpha-(2-piperidinoethyl)-1-naphthaleneacetonitrile
1-Piperidinebutyronitrile, alpha-isopropyl-alpha-1-naphthyl-
1-Piperidinebutyronitrile, .alpha.-isopropyl-.alpha.-1-naphthyl-
NSC-171376
1-Naphthaleneacetonitrile, .alpha.-isopropyl-.alpha.-(2-piperidinoethyl)-