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Nomifensine

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Identification
Molecular formula
C20H24N2O
CAS number
24526-64-5
IUPAC name
3-methyl-2-(2-morpholinoethyl)-2-(1-naphthyl)butanenitrile
State
State
At room temperature, Nomifensine is typically found in a solid state. This solid form is due to its crystalline structure, which is stable under standard conditions. It does not vaporize easily at room temperature.
Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
503.80
Boiling point (Kelvin)
776.95
General information
Molecular weight
308.42g/mol
Molar mass
264.3530g/mol
Density
1.1620g/cm3
Appearence

Nomifensine typically appears as a white or off-white crystalline powder. It is often odorless and can be sensitive to light. Its crystalline nature means it may have a slightly shiny appearance due to the crystal facets reflecting light.

Comment on solubility

Solubility of 3-methyl-2-(2-morpholinoethyl)-2-(1-naphthyl)butanenitrile

The solubility of 3-methyl-2-(2-morpholinoethyl)-2-(1-naphthyl)butanenitrile can be influenced by various factors including polarity, molecular structure, and solvent interactions. Generally, the following points can help to assess its solubility:

  • Polarity: This compound contains both polar and non-polar functional groups, which could lead to variable solubility in different solvents.
  • Solvent Compatibility: It might exhibit better solubility in organic solvents like ethanol, DMSO (dimethyl sulfoxide), or acetone, while showing limited solubility in water due to its hydrophobic naphthalene component.
  • Molecular Interactions: The presence of the morpholino group may enhance solubility in polar solvents through hydrogen bonding, whereas the naphthyl group may introduce hydrophobic characteristics.

In general, predicting the solubility of this compound in a specific solvent should involve experimental verification, as its intricate structure can lead to unique interactions. As with many compounds, "like dissolves like" is a fundamental rule to keep in mind. Solubility testing in various solvents is crucial to confirm its behavior, particularly in applications involving drug formulation or chemical synthesis.

Interesting facts

Interesting Facts about 3-methyl-2-(2-morpholinoethyl)-2-(1-naphthyl)butanenitrile

This compound, widely recognized for its complex molecular structure, has captivated the attention of chemists for various reasons:

  • Pharmaceutical Potential: The unique structure of this compound suggests potential applications in the pharmaceutical industry, particularly in the development of new drugs. Compounds with naphthalene moieties have been shown to exhibit various biological activities.
  • Structural Complexity: Its intricate framework combines a naphthyl group with a morpholino substituent, making it a fascinating subject of study in medicinal chemistry and organic synthesis.
  • Research Applications: The compound can be utilized in research focused on understanding interactions at the molecular level, particularly in studies involving receptor binding and cellular responses.
  • Synthetic Pathways: The synthesis of this compound involves several steps. Aspiring chemists might appreciate the challenge of constructing its elaborate structure through methods like nucleophilic substitutions and cyclizations.
  • Interdisciplinary Connections: This compound is a perfect example of how various fields such as organic chemistry, biochemistry, and pharmacology intersect, highlighting the importance of collaboration in scientific advancements.

In summary, 3-methyl-2-(2-morpholinoethyl)-2-(1-naphthyl)butanenitrile is not just another compound; it represents a plethora of opportunities for exploration in both theoretical and practical realms of chemistry.

Synonyms
1238-65-9
alpha-Isopropyl-alpha-(2-morpholinoethyl)-1-naphthaleneacetonitrile
BRN 1086852
1-NAPHTHALENEACETONITRILE, alpha-ISOPROPYL-alpha-(2-MORPHOLINOETHYL)-
3-methyl-2-(2-morpholin-4-ylethyl)-2-naphthalen-1-ylbutanenitrile
DTXSID50924606
3-methyl-2-[2-(morpholin-4-yl)ethyl]-2-(naphthalen-1-yl)butanenitrile